TY - JOUR
T1 - Maternal psychosocial stress and children’s ADHD diagnosis
T2 - a prospective birth cohort study
AU - Okano, Lauren
AU - Ji, Yuelong
AU - Riley, Anne W.
AU - Wang, Xiaobin
N1 - Funding Information:
This work was supported in part by the grants from the Maternal and Child Health Bureau of the Health Resources and Services Administration (HRSA) [R40MC27443 and UJ2MC31074] and the Boston Birth Cohort (the parent study) was supported in part by the grants from the National Institutes of Health (NIH) [2R01HD041702, R01HD086013, and R21HD085556].
Publisher Copyright:
© 2018, Taylor and Francis Ltd. All rights reserved.
PY - 2019
Y1 - 2019
N2 - Objective: Examine the association of mothers’ psychosocial stressors before and during pregnancy with their children’s diagnosis of attention deficit hyperactivity disorder (ADHD). Methods: This study included 2140 mother–child pairs who had at least one postnatal pediatric visit at the Boston Medical Center between 2003 and 2015. Child ADHD was determined via International Classification of Diseases, Ninth Revision (ICD-9) codes documented in electronic medical records. Latent factors of maternal stress and social support and measures of the physical home environment and psychosocial adversities were constructed using exploratory factor analysis. The association between the latent factors and child ADHD diagnosis was examined using multiple logistic regression, controlling for known risk factors for ADHD. Results: Children were 1.45 (95% CI: 1.06, 1.99) and 3.03 (95% CI: 2.19, 4.20) times more likely to receive an ADHD diagnosis if their mother experienced a major stressful event during pregnancy or reported a high level of perceived stress, respectively. The number of family adversities increases the risk of ADHD diagnosis [second quartile: OR ¼ 1.90; CI (1.31, 2.77); third quartile: OR ¼ 1.96 CI (1.34, 2.88); fourth quartile: OR ¼ 2.89 CI (2.01, 4.16)] compared to first quartile. Conclusions: In this prospective, predominantly urban, low-income, minority birth cohort, moth-ers’ psychosocial stress before and during pregnancy appears to be an independent risk factor for the development of ADHD in their children.
AB - Objective: Examine the association of mothers’ psychosocial stressors before and during pregnancy with their children’s diagnosis of attention deficit hyperactivity disorder (ADHD). Methods: This study included 2140 mother–child pairs who had at least one postnatal pediatric visit at the Boston Medical Center between 2003 and 2015. Child ADHD was determined via International Classification of Diseases, Ninth Revision (ICD-9) codes documented in electronic medical records. Latent factors of maternal stress and social support and measures of the physical home environment and psychosocial adversities were constructed using exploratory factor analysis. The association between the latent factors and child ADHD diagnosis was examined using multiple logistic regression, controlling for known risk factors for ADHD. Results: Children were 1.45 (95% CI: 1.06, 1.99) and 3.03 (95% CI: 2.19, 4.20) times more likely to receive an ADHD diagnosis if their mother experienced a major stressful event during pregnancy or reported a high level of perceived stress, respectively. The number of family adversities increases the risk of ADHD diagnosis [second quartile: OR ¼ 1.90; CI (1.31, 2.77); third quartile: OR ¼ 1.96 CI (1.34, 2.88); fourth quartile: OR ¼ 2.89 CI (2.01, 4.16)] compared to first quartile. Conclusions: In this prospective, predominantly urban, low-income, minority birth cohort, moth-ers’ psychosocial stress before and during pregnancy appears to be an independent risk factor for the development of ADHD in their children.
KW - Attention-deficit hyperactivity disorder
KW - maternal psychosocial stress
KW - perinatal epidemiology
KW - prospective birth cohort study
KW - psychosomatic gynecology
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U2 - 10.1080/0167482X.2018.1468434
DO - 10.1080/0167482X.2018.1468434
M3 - Article
C2 - 29790815
AN - SCOPUS:85047246297
VL - 40
SP - 217
EP - 225
JO - Journal of Psychosomatic Obstetrics and Gynaecology
JF - Journal of Psychosomatic Obstetrics and Gynaecology
SN - 0167-482X
IS - 3
ER -