Abstract
Objective: Examine the association of mothers’ psychosocial stressors before and during pregnancy with their children’s diagnosis of attention deficit hyperactivity disorder (ADHD). Methods: This study included 2140 mother–child pairs who had at least one postnatal pediatric visit at the Boston Medical Center between 2003 and 2015. Child ADHD was determined via International Classification of Diseases, Ninth Revision (ICD-9) codes documented in electronic medical records. Latent factors of maternal stress and social support and measures of the physical home environment and psychosocial adversities were constructed using exploratory factor analysis. The association between the latent factors and child ADHD diagnosis was examined using multiple logistic regression, controlling for known risk factors for ADHD. Results: Children were 1.45 (95% CI: 1.06, 1.99) and 3.03 (95% CI: 2.19, 4.20) times more likely to receive an ADHD diagnosis if their mother experienced a major stressful event during pregnancy or reported a high level of perceived stress, respectively. The number of family adversities increases the risk of ADHD diagnosis [second quartile: OR = 1.90; CI (1.31, 2.77); third quartile: OR = 1.96 CI (1.34, 2.88); fourth quartile: OR = 2.89 CI (2.01, 4.16)] compared to first quartile. Conclusions: In this prospective, predominantly urban, low-income, minority birth cohort, mothers’ psychosocial stress before and during pregnancy appears to be an independent risk factor for the development of ADHD in their children.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-9 |
| Number of pages | 9 |
| Journal | Journal of Psychosomatic Obstetrics and Gynecology |
| DOIs | |
| State | Accepted/In press - May 23 2018 |
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Keywords
- Attention-deficit hyperactivity disorder
- maternal psychosocial stress
- perinatal epidemiology
- prospective birth cohort study
- psychosomatic gynecology
ASJC Scopus subject areas
- Reproductive Medicine
- Clinical Psychology
- Obstetrics and Gynecology
- Psychiatry and Mental health
Cite this
Maternal psychosocial stress and children’s ADHD diagnosis : a prospective birth cohort study. / Okano, Lauren; Ji, Yuelong; Riley, Anne W; Wang, Xiaobin.
In: Journal of Psychosomatic Obstetrics and Gynecology, 23.05.2018, p. 1-9.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Maternal psychosocial stress and children’s ADHD diagnosis
T2 - a prospective birth cohort study
AU - Okano, Lauren
AU - Ji, Yuelong
AU - Riley, Anne W
AU - Wang, Xiaobin
PY - 2018/5/23
Y1 - 2018/5/23
N2 - Objective: Examine the association of mothers’ psychosocial stressors before and during pregnancy with their children’s diagnosis of attention deficit hyperactivity disorder (ADHD). Methods: This study included 2140 mother–child pairs who had at least one postnatal pediatric visit at the Boston Medical Center between 2003 and 2015. Child ADHD was determined via International Classification of Diseases, Ninth Revision (ICD-9) codes documented in electronic medical records. Latent factors of maternal stress and social support and measures of the physical home environment and psychosocial adversities were constructed using exploratory factor analysis. The association between the latent factors and child ADHD diagnosis was examined using multiple logistic regression, controlling for known risk factors for ADHD. Results: Children were 1.45 (95% CI: 1.06, 1.99) and 3.03 (95% CI: 2.19, 4.20) times more likely to receive an ADHD diagnosis if their mother experienced a major stressful event during pregnancy or reported a high level of perceived stress, respectively. The number of family adversities increases the risk of ADHD diagnosis [second quartile: OR = 1.90; CI (1.31, 2.77); third quartile: OR = 1.96 CI (1.34, 2.88); fourth quartile: OR = 2.89 CI (2.01, 4.16)] compared to first quartile. Conclusions: In this prospective, predominantly urban, low-income, minority birth cohort, mothers’ psychosocial stress before and during pregnancy appears to be an independent risk factor for the development of ADHD in their children.
AB - Objective: Examine the association of mothers’ psychosocial stressors before and during pregnancy with their children’s diagnosis of attention deficit hyperactivity disorder (ADHD). Methods: This study included 2140 mother–child pairs who had at least one postnatal pediatric visit at the Boston Medical Center between 2003 and 2015. Child ADHD was determined via International Classification of Diseases, Ninth Revision (ICD-9) codes documented in electronic medical records. Latent factors of maternal stress and social support and measures of the physical home environment and psychosocial adversities were constructed using exploratory factor analysis. The association between the latent factors and child ADHD diagnosis was examined using multiple logistic regression, controlling for known risk factors for ADHD. Results: Children were 1.45 (95% CI: 1.06, 1.99) and 3.03 (95% CI: 2.19, 4.20) times more likely to receive an ADHD diagnosis if their mother experienced a major stressful event during pregnancy or reported a high level of perceived stress, respectively. The number of family adversities increases the risk of ADHD diagnosis [second quartile: OR = 1.90; CI (1.31, 2.77); third quartile: OR = 1.96 CI (1.34, 2.88); fourth quartile: OR = 2.89 CI (2.01, 4.16)] compared to first quartile. Conclusions: In this prospective, predominantly urban, low-income, minority birth cohort, mothers’ psychosocial stress before and during pregnancy appears to be an independent risk factor for the development of ADHD in their children.
KW - Attention-deficit hyperactivity disorder
KW - maternal psychosocial stress
KW - perinatal epidemiology
KW - prospective birth cohort study
KW - psychosomatic gynecology
UR - http://www.scopus.com/inward/record.url?scp=85047246297&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85047246297&partnerID=8YFLogxK
U2 - 10.1080/0167482X.2018.1468434
DO - 10.1080/0167482X.2018.1468434
M3 - Article
C2 - 29790815
AN - SCOPUS:85047246297
SP - 1
EP - 9
JO - Journal of Psychosomatic Obstetrics and Gynaecology
JF - Journal of Psychosomatic Obstetrics and Gynaecology
SN - 0167-482X
ER -