TY - JOUR
T1 - Maternal obesity associated with inflammation in their children
AU - Leibowitz, Karen L.
AU - Moore, Reneé H.
AU - Ahima, Rexford S.
AU - Stunkard, Albert J.
AU - Stallings, Virginia A.
AU - Berkowitz, Robert I.
AU - Chittams, Jesse L.
AU - Faith, Myles S.
AU - Stettler, Nicolas
PY - 2012/2/1
Y1 - 2012/2/1
N2 - Background: This study explored the association between maternal obesity during pregnancy and the inflammatory markers, tumor necrosis factor-α, interleukin-6 and high sensitivity C-reactive protein (hs-CRP), and the cytokine, adiponectin, in the offspring. Methods: Weight, height, Tanner stage and biomarkers were measured in thirty-four 12-year-old children, from the Infant Growth Study, who were divided into high risk (HR) and low risk (LR) groups based on maternal pre-pregnancy body mass index (BMI). Results: The two groups differed markedly in their hs-CRP levels, but no group difference was found for the other three biomarkers. The odds ratio (OR) of HR children having detectable hs-CRP levels was 16 times greater than that of LR children after adjusting for confounding variables, including BMI z-score, Tanner stages and gender (OR: 16; 95% CI: 2-123). Conclusions: These results suggest that maternal obesity during pregnancy is associated with later development of elevated hs-CRP in the offspring, even after controlling for weight.
AB - Background: This study explored the association between maternal obesity during pregnancy and the inflammatory markers, tumor necrosis factor-α, interleukin-6 and high sensitivity C-reactive protein (hs-CRP), and the cytokine, adiponectin, in the offspring. Methods: Weight, height, Tanner stage and biomarkers were measured in thirty-four 12-year-old children, from the Infant Growth Study, who were divided into high risk (HR) and low risk (LR) groups based on maternal pre-pregnancy body mass index (BMI). Results: The two groups differed markedly in their hs-CRP levels, but no group difference was found for the other three biomarkers. The odds ratio (OR) of HR children having detectable hs-CRP levels was 16 times greater than that of LR children after adjusting for confounding variables, including BMI z-score, Tanner stages and gender (OR: 16; 95% CI: 2-123). Conclusions: These results suggest that maternal obesity during pregnancy is associated with later development of elevated hs-CRP in the offspring, even after controlling for weight.
KW - Children
KW - Inflammation
KW - Maternal obesity
KW - hs-C-reactive protein
UR - http://www.scopus.com/inward/record.url?scp=84859800685&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84859800685&partnerID=8YFLogxK
U2 - 10.1007/s12519-011-0292-6
DO - 10.1007/s12519-011-0292-6
M3 - Article
C2 - 21874618
AN - SCOPUS:84859800685
VL - 8
SP - 76
EP - 79
JO - World Journal of Pediatrics
JF - World Journal of Pediatrics
SN - 1708-8569
IS - 1
ER -