TY - JOUR
T1 - Maternal obesity associated with inflammation in their children
AU - Leibowitz, Karen L.
AU - Moore, Reneé H.
AU - Ahima, Rexford S.
AU - Stunkard, Albert J.
AU - Stallings, Virginia A.
AU - Berkowitz, Robert I.
AU - Chittams, Jesse L.
AU - Faith, Myles S.
AU - Stettler, Nicolas
N1 - Funding Information:
Funding: This work was supported by National Institute of Health grant DK068899, General Clinical Research Center grant RR00240, General Clinical Research Center/Clinical Translational Research Center grant UL1-RR-024134, and the Nutrition and Growth Laboratory of Children's Hospital of Philadelphia. National Institute of Health grant DK068899, General Clinical Research Center grant RR00240, General Clinical Research Center/Clinical Translational Research Center grant UL1-RR-024134, and the Nutrition and Growth Laboratory of Children's Hospital of Philadelphia. The analyses of the inflammatory markers were supported by a Pilot and Feasibility Study Grant from the Institute for Diabetes, Obesity and Metabolism Unit (NIH grant DK 19525) and the RIA/Biomarkers Core of the Pennsylvania Diabetes Center (NIH grant DK 19525). Ethical approval: None. Competing interest: The authors have no conflicts of interest to report. Contributors: Leibowitz KL, Stettler N, and Moore RH contributed to the study design, conduction as well as writing the paper. All other authors were involved in the acquizition of the data, concept and design and approved the final version of the manuscript.
PY - 2012/2
Y1 - 2012/2
N2 - Background: This study explored the association between maternal obesity during pregnancy and the inflammatory markers, tumor necrosis factor-α, interleukin-6 and high sensitivity C-reactive protein (hs-CRP), and the cytokine, adiponectin, in the offspring. Methods: Weight, height, Tanner stage and biomarkers were measured in thirty-four 12-year-old children, from the Infant Growth Study, who were divided into high risk (HR) and low risk (LR) groups based on maternal pre-pregnancy body mass index (BMI). Results: The two groups differed markedly in their hs-CRP levels, but no group difference was found for the other three biomarkers. The odds ratio (OR) of HR children having detectable hs-CRP levels was 16 times greater than that of LR children after adjusting for confounding variables, including BMI z-score, Tanner stages and gender (OR: 16; 95% CI: 2-123). Conclusions: These results suggest that maternal obesity during pregnancy is associated with later development of elevated hs-CRP in the offspring, even after controlling for weight.
AB - Background: This study explored the association between maternal obesity during pregnancy and the inflammatory markers, tumor necrosis factor-α, interleukin-6 and high sensitivity C-reactive protein (hs-CRP), and the cytokine, adiponectin, in the offspring. Methods: Weight, height, Tanner stage and biomarkers were measured in thirty-four 12-year-old children, from the Infant Growth Study, who were divided into high risk (HR) and low risk (LR) groups based on maternal pre-pregnancy body mass index (BMI). Results: The two groups differed markedly in their hs-CRP levels, but no group difference was found for the other three biomarkers. The odds ratio (OR) of HR children having detectable hs-CRP levels was 16 times greater than that of LR children after adjusting for confounding variables, including BMI z-score, Tanner stages and gender (OR: 16; 95% CI: 2-123). Conclusions: These results suggest that maternal obesity during pregnancy is associated with later development of elevated hs-CRP in the offspring, even after controlling for weight.
KW - Children
KW - Inflammation
KW - Maternal obesity
KW - hs-C-reactive protein
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U2 - 10.1007/s12519-011-0292-6
DO - 10.1007/s12519-011-0292-6
M3 - Article
C2 - 21874618
AN - SCOPUS:84859800685
SN - 1708-8569
VL - 8
SP - 76
EP - 79
JO - World Journal of Pediatrics
JF - World Journal of Pediatrics
IS - 1
ER -