@article{4ae2c16475a94b23b30e318aed52e35e,
title = "Maternal neutralizing antibody and transmission of hepatitis C virus to infants",
abstract = "To determine whether lower levels of hepatitis C virus (HCV)-specific neutralizing antibodies (nAb) are associated with an increased risk of mother-to-child transmission (MTCT) of HCV, HCV nAb titers were assessed in 63 mothers coinfected with HCV and human immunodeficiency virus (HIV) type 1. Of the mothers, 16 transmitted HCV to their infant, but no difference was detected between the ability of maternal plasma from transmitters and nontransmitters to neutralize heterologous HCV pseudoparticles (median nAb titer, 1:125 vs. 1:100; P = .23). In the setting of HIV/HCV coinfection, we found no evidence that HCV nAbs are associated with the prevention of MTCT of HCV.",
author = "Dowd, {Kimberly A.} and Hershow, {Ronald C.} and Sigal Yawetz and Philip LaRussa and Clemente Diaz and Landesman, {Sheldon H.} and Paul, {Mary E.} and Read, {Jennifer S.} and Ming Lu and Thomas, {David L.} and Netski, {Dale M.} and Ray, {Stuart C.}",
note = "Funding Information: Received 15 April 2008; accepted 27 June 2008; electronically published 17 October 2008. Potential conflicts of interest: none reported. Financial support: National Institutes of Health (grant DK-068555 to D.M.N.). Funding sources for the Women and Infants Transmission Study are listed at the end of the text, along with additional members of the study group. Reprints or correspondence: Dr. Stuart C. Ray, Johns Hopkins Univ. School of Medicine, 855 N. Wolfe St., Suite 530, Baltimore, MD 21205 (sray@jhmi.edu). Funding Information: WITS. Principal investigators, study coordinators, program officers, and funding for WITS include the following: Clemente Diaz and Edna Pacheco-Acosta (University of Puerto Rico, San Juan; grant U01 AI 34858); Ruth Tuomala, Ellen Cooper, and Donna Mesthene (Boston/Worcester Site, Boston, Massachusetts; grant 9U01 DA 15054); Phil LaRussa and Alice Higgins (Columbia Presbyterian Hospital, New York, New York; grant U01 DA 15053); Sheldon Landesman, Hermann Mendez, Edward Handelsman, and Ava Dennie (State University of New York, Brooklyn; grant HD-3– 6117); Kenneth Rich and Delmyra Turpin (University of Illinois at Chicago, Chicago; grant U01 AI 34841); William Shearer and Norma Cooper (Baylor College of Medicine, Houston, Texas; grant U01 HD 41983); Joana Rosario (National Institute of Allergy and Infectious Diseases, Bethesda, Maryland); Kevin Ryan (Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland); Vincent Smeriglio and Katherine Davenny (National Institute on Drug Abuse, Bethesda, Maryland); and Bruce Thompson (Clinical Trials and Surveys, Baltimore, Maryland; grant N01 AI 085339). The Scientific Leadership Core included Kenneth Rich (principal investigator) and Delmyra Turpin (study coordinator) (grant U01 AI 50274 – 01). Additional support was provided by local clinical research centers, as follows: Children{\textquoteright}s Hospital Boston, Boston, Massachusetts (NIH grant GCRC RR02174); Baylor College of Medicine, Houston, Texas (NIH grant GCRC RR00188); and Columbia University, New York, New York (NIH grant GCRC RR00645).",
year = "2008",
month = dec,
day = "1",
doi = "10.1086/593067",
language = "English (US)",
volume = "198",
pages = "1651--1655",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "11",
}