Maternal low-dose vitamin A or β-carotene supplementation has no effect on fetal loss and early infant mortality: A randomized cluster trial in Nepal

Joanne Katz, Keith P. West, Suborna K. Khatry, Elizabeth K. Pradhan, Steven C. LeClerq, Parul Christian, Lee Shu Fune Wu, Ramesh K. Adhikari, Sharada R. Shrestha, Alfred Sommer, Ram P. Pokhrel, Sanu M. Dali, Bhakta Raj Dahal, Michele Dreyfuss, Rebecca Stoltzfus, James Tielsch, Sedigheh Yamini-Roodsari, Noor Nath Acharya, Dev N. Mandal, Paul ConnorKerry Schulze, Tirtha R. Shakya, Andre Hackman, Gwendolyn Clemens

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The effect of vitamin A supplementation on the survival of infants aged <6 mo is unclear. Because most infant deaths occur in the first few month of life, maternal supplementation may improve infant survival. Objectives: The objective was to assess the effect of maternal vitamin A or β-carotene supplementation on fetal loss and survival of infants <6 mo of age. Design: Married women of reproductive age in 270 wards of Sarlahi district, Nepal, were eligible to participate. Wards were randomly assigned to have women receive weekly doses of 7000 μg retinol equivalents as retinyl palmitate (vitamin A), 42 mg all-trans-β-carotene, or placebo. Pregnancies were followed until miscarriage, stillbirth, maternal death, or live birth of one or more infants, who were followed through 24 wk of age. Results: A total of 43 559 women were enrolled; 15832 contributed 17 373 pregnancies and 15 987 live born infants to the trial. The rate of fetal loss was 92.0/1000 pregnancies in the placebo group, comparable with rates in the vitamin A and β-carotene groups, which had relative risks of 1.06 (95% CI: 0.91, 1.25) and 1.03 (95% CI: 0.87, 1.19), respectively. The 24-wk mortality rate was 70.8/1000 live births in the placebo group, comparable with rates in the vitamin A and β-carotene groups, which had relative risks of 1.05 (95% CI: 0.87, 1.25) and 1.03 (95% CI: 0.86, 1.22), respectively. Conclusions: Small weekly doses of vitamin A or β-carotene given to women before conception, during pregnancy, and through 24 Wk postpartum did not improve fetal or early infant survival in Nepal.

Original languageEnglish (US)
Pages (from-to)1570-1576
Number of pages7
JournalAmerican Journal of Clinical Nutrition
Volume71
Issue number6
DOIs
StatePublished - Jun 2000

Keywords

  • Child survival
  • Fetal loss
  • Infant mortality
  • Maternal supplementation
  • Nepal
  • The Nepal Nutrition Intervention Project- Sarlahi Study Group
  • Vitamin A
  • β-carotene

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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