Maternal Exposure to Occupational Asthmagens During Pregnancy and Autism Spectrum Disorder in the Study to Explore Early Development

Alison B. Singer, Gayle C. Windham, Lisa A. Croen, Julie L. Daniels, Brian K. Lee, Yinge Qian, Diana E. Schendel, Daniele Daniele Fallin, Igor Burstyn

Research output: Contribution to journalArticle

Abstract

Maternal immune activity has been linked to children with autism spectrum disorder (ASD). We examined maternal occupational exposure to asthma-causing agents during pregnancy in relation to ASD risk. Our sample included 463 ASD cases and 710 general population controls from the Study to Explore Early Development whose mothers reported at least one job during pregnancy. Asthmagen exposure was estimated from a published job-exposure matrix. The adjusted odds ratio for ASD comparing asthmagen-exposed to unexposed was 1.39 (95 % CI 0.96–2.02). Maternal workplace asthmagen exposure was not associated with ASD risk in this study, but this result does not exclude some involvement of maternal exposure to asthma-causing agents in ASD.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalJournal of Autism and Developmental Disorders
DOIs
StateAccepted/In press - Aug 10 2016

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Maternal Exposure
Pregnancy
Mothers
Asthma
Population Control
Occupational Exposure
Workplace
Autism Spectrum Disorder
Odds Ratio

Keywords

  • Allergy
  • Asthma
  • Autism
  • Exposure
  • Maternal
  • Maternal occupation

ASJC Scopus subject areas

  • Medicine(all)
  • Developmental and Educational Psychology

Cite this

Maternal Exposure to Occupational Asthmagens During Pregnancy and Autism Spectrum Disorder in the Study to Explore Early Development. / Singer, Alison B.; Windham, Gayle C.; Croen, Lisa A.; Daniels, Julie L.; Lee, Brian K.; Qian, Yinge; Schendel, Diana E.; Fallin, Daniele Daniele; Burstyn, Igor.

In: Journal of Autism and Developmental Disorders, 10.08.2016, p. 1-11.

Research output: Contribution to journalArticle

Singer, Alison B. ; Windham, Gayle C. ; Croen, Lisa A. ; Daniels, Julie L. ; Lee, Brian K. ; Qian, Yinge ; Schendel, Diana E. ; Fallin, Daniele Daniele ; Burstyn, Igor. / Maternal Exposure to Occupational Asthmagens During Pregnancy and Autism Spectrum Disorder in the Study to Explore Early Development. In: Journal of Autism and Developmental Disorders. 2016 ; pp. 1-11.
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