Maternal Exposure to Occupational Asthmagens During Pregnancy and Autism Spectrum Disorder in the Study to Explore Early Development

Alison B. Singer; Gayle C. Windham; Lisa A. Croen; Julie L. Daniels; Brian K. Lee; Yinge Qian; Diana E. Schendel; M. Daniele Fallin; Igor Burstyn

doi:10.1007/s10803-016-2882-6

Maternal Exposure to Occupational Asthmagens During Pregnancy and Autism Spectrum Disorder in the Study to Explore Early Development

Alison B. Singer, Gayle C. Windham, Lisa A. Croen, Julie L. Daniels, Brian K. Lee, Yinge Qian, Diana E. Schendel, M. Daniele Fallin, Igor Burstyn

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Maternal immune activity has been linked to children with autism spectrum disorder (ASD). We examined maternal occupational exposure to asthma-causing agents during pregnancy in relation to ASD risk. Our sample included 463 ASD cases and 710 general population controls from the Study to Explore Early Development whose mothers reported at least one job during pregnancy. Asthmagen exposure was estimated from a published job-exposure matrix. The adjusted odds ratio for ASD comparing asthmagen-exposed to unexposed was 1.39 (95 % CI 0.96–2.02). Maternal workplace asthmagen exposure was not associated with ASD risk in this study, but this result does not exclude some involvement of maternal exposure to asthma-causing agents in ASD.

Original language	English (US)
Pages (from-to)	3458-3468
Number of pages	11
Journal	Journal of Autism and Developmental Disorders
Volume	46
Issue number	11
DOIs	https://doi.org/10.1007/s10803-016-2882-6
State	Published - Nov 1 2016

Keywords

Allergy
Asthma
Autism
Exposure
Maternal
Maternal occupation

ASJC Scopus subject areas

Developmental and Educational Psychology

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10.1007/s10803-016-2882-6

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Singer, A. B., Windham, G. C., Croen, L. A., Daniels, J. L., Lee, B. K., Qian, Y., Schendel, D. E., Fallin, M. D., & Burstyn, I. (2016). Maternal Exposure to Occupational Asthmagens During Pregnancy and Autism Spectrum Disorder in the Study to Explore Early Development. Journal of Autism and Developmental Disorders, 46(11), 3458-3468. https://doi.org/10.1007/s10803-016-2882-6

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title = "Maternal Exposure to Occupational Asthmagens During Pregnancy and Autism Spectrum Disorder in the Study to Explore Early Development",

abstract = "Maternal immune activity has been linked to children with autism spectrum disorder (ASD). We examined maternal occupational exposure to asthma-causing agents during pregnancy in relation to ASD risk. Our sample included 463 ASD cases and 710 general population controls from the Study to Explore Early Development whose mothers reported at least one job during pregnancy. Asthmagen exposure was estimated from a published job-exposure matrix. The adjusted odds ratio for ASD comparing asthmagen-exposed to unexposed was 1.39 (95 % CI 0.96–2.02). Maternal workplace asthmagen exposure was not associated with ASD risk in this study, but this result does not exclude some involvement of maternal exposure to asthma-causing agents in ASD.",

keywords = "Allergy, Asthma, Autism, Exposure, Maternal, Maternal occupation",

author = "Singer, {Alison B.} and Windham, {Gayle C.} and Croen, {Lisa A.} and Daniels, {Julie L.} and Lee, {Brian K.} and Yinge Qian and Schendel, {Diana E.} and Fallin, {M. Daniele} and Igor Burstyn",

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AU - Singer, Alison B.

AU - Windham, Gayle C.

AU - Croen, Lisa A.

AU - Daniels, Julie L.

AU - Lee, Brian K.

AU - Qian, Yinge

AU - Schendel, Diana E.

AU - Fallin, M. Daniele

AU - Burstyn, Igor

PY - 2016/11/1

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N2 - Maternal immune activity has been linked to children with autism spectrum disorder (ASD). We examined maternal occupational exposure to asthma-causing agents during pregnancy in relation to ASD risk. Our sample included 463 ASD cases and 710 general population controls from the Study to Explore Early Development whose mothers reported at least one job during pregnancy. Asthmagen exposure was estimated from a published job-exposure matrix. The adjusted odds ratio for ASD comparing asthmagen-exposed to unexposed was 1.39 (95 % CI 0.96–2.02). Maternal workplace asthmagen exposure was not associated with ASD risk in this study, but this result does not exclude some involvement of maternal exposure to asthma-causing agents in ASD.

AB - Maternal immune activity has been linked to children with autism spectrum disorder (ASD). We examined maternal occupational exposure to asthma-causing agents during pregnancy in relation to ASD risk. Our sample included 463 ASD cases and 710 general population controls from the Study to Explore Early Development whose mothers reported at least one job during pregnancy. Asthmagen exposure was estimated from a published job-exposure matrix. The adjusted odds ratio for ASD comparing asthmagen-exposed to unexposed was 1.39 (95 % CI 0.96–2.02). Maternal workplace asthmagen exposure was not associated with ASD risk in this study, but this result does not exclude some involvement of maternal exposure to asthma-causing agents in ASD.

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KW - Asthma

KW - Autism

KW - Exposure

KW - Maternal

KW - Maternal occupation

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Maternal Exposure to Occupational Asthmagens During Pregnancy and Autism Spectrum Disorder in the Study to Explore Early Development

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Keywords

ASJC Scopus subject areas

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