@article{3d7a1c50502e43cab229136b67f08923,
title = "Maternal biomarkers of acetaminophen use and offspring attention deficit hyperactivity disorder",
abstract = "Previous studies have suggested a positive association between self-reported maternal acetaminophen use during pregnancy and risk of attention deficit hyperactivity disorder (ADHD) in offspring. We sought to examine the prospective association between maternal plasma biomarkers of acetaminophen intake and ADHD diagnosis in the offspring. This report analyzed 1180 children enrolled at birth and followed prospectively as part of the Boston Birth Cohort, including 188 with ADHD diagnosis based on electronic medical record review. Maternal biomarkers of acetaminophen intake were measured in plasma samples obtained within 1–3 days postpartum. Odds ratios for having ADHD diagnosis or other developmental disorders were estimated using multinomial logistic regression models, adjusting for pertinent covariables. Compared to neurotypical children, we observed significant positive dose-responsive associations with ADHD diagnosis for each maternal acetaminophen biomarker. These dose–responsive associations persisted after adjusting for indication of acetaminophen use and other pertinent covariates; and were specific to ADHD, rather than other neurodevelopmental disorders. In the stratified analyses, differential point estimates of the associations were observed across some strata of covariates. However, these differences were not statistically significant. Maternal acetaminophen biomarkers were specifically associated with increased risk of ADHD diagnosis in offspring. Additional clinical and mechanistic investigations are warranted.",
keywords = "ADHD, Acetaminophen, Pregnancy",
author = "Yuelong Ji and Riley, {Anne W.} and Lee, {Li Ching} and Xiumei Hong and Guoying Wang and Tsai, {Hui Ju} and Mueller, {Noel T.} and Colleen Pearson and Jessica Thermitus and Anita Panjwani and Hongkai Ji and Bartell, {Tami R.} and Irina Burd and Fallin, {M. Daniele} and Xiaobin Wang",
note = "Funding Information: This work was supported by the Health Resources and Services Administration (HRSA) of the U.S. Department of Health and Human Services (HHS) under grant number R40MC27443 and UJ2MC31074. The Boston Birth Cohort (the parent study) is supported in part by the March of Dimes PERI grants (20-FY02-56 and 21-FY07-605); and the National Institutes of Health (NIH) grants (R21ES011666, R01HD041702, R21HD066471, U01AI090727, R21AI079872, 2R01HD041702, and R01HD086013). The content and conclusions contained in this article are those of the authors and should not be construed as the official position or policy of, nor should any endorsements be inferred by HRSA, HHS or the U.S. Government. Funding Information: Funding: This work was supported by the Health Resources and Services Administration (HRSA) of the U.S. Department of Health and Human Services (HHS) under grant number R40MC27443 and UJ2MC31074. The Boston Birth Cohort (the parent study) is supported in part by the March of Dimes PERI grants (20-FY02-56 and 21-FY07-605); and the National Institutes of Health (NIH) grants (R21ES011666, R01HD041702, R21HD066471, U01AI090727, R21AI079872, 2R01HD041702, and R01HD086013). The content and conclusions contained in this article are those of the authors and should not be construed as the official position or policy of, nor should any endorsements be inferred by HRSA, HHS or the U.S. Government. Publisher Copyright: {\textcopyright} 2018 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2018",
month = jul,
doi = "10.3390/brainsci8070127",
language = "English (US)",
volume = "8",
journal = "Brain Sciences",
issn = "2076-3425",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "7",
}