Maternal and umbilical resistin levels do not correlate with infant birth weight either in normal pregnancies and or in pregnancies complicated with gestational diabetes

Nikolaos Vitoratos, Alexandra Dimitrakaki, Nikolaos F. Vlahos, Odysseas Gregoriou, Kostantinos Panoulis, Panagiotis Christopoulos, George Creatsas

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Objective. To evaluate the role of resistin in the pathophysiology of insulin resistance during pregnancy and on the birth weight of infants born from women with gestational diabetes (GDM). Material and methods.Thirty women diagnosed with GDM were compared to 30 normal pregnant controls. Maternal serum resistin and insulin levels were measured at the time of the oral glucose tolerance test screening. In addition, umbilical levels of resistin and insulin were measured at the time of delivery. Results. There was no difference in maternal serum resistin levels in women with GDM as compared to normal controls at 24-26 weeks. There was no difference in umbilical resistin levels between the infants born in the two groups. There was no correlation between infant weight and either maternal resistin at 24-26 week or umbilical resistin levels. Conclusion.There were no significant differences in umbilical resistin levels between infants born of women with GDM as compared to normal pregnant women. In addition, there was no correlation between resistin levels during pregnancy, as well as between umbilical resistin levels and neonatal birth weight. In conclusion, resistin seems to play a rather minor role in the pathophysiology of GDM and the energy metabolism during fetal life.

    Original languageEnglish (US)
    Pages (from-to)1019-1023
    Number of pages5
    JournalJournal of Maternal-Fetal and Neonatal Medicine
    Volume23
    Issue number9
    DOIs
    StatePublished - Sep 1 2010

    Keywords

    • Gestational diabetes
    • HOMA
    • birthweight
    • pregnancy
    • resistin

    ASJC Scopus subject areas

    • Pediatrics, Perinatology, and Child Health
    • Obstetrics and Gynecology

    Fingerprint Dive into the research topics of 'Maternal and umbilical resistin levels do not correlate with infant birth weight either in normal pregnancies and or in pregnancies complicated with gestational diabetes'. Together they form a unique fingerprint.

    Cite this