Maternal and infant factors predicting disease progression in human immunodeficiency virus type 1-infected infants. Women and Infants Transmission Study Group.

K. C. Rich, M. G. Fowler, L. M. Mofenson, R. Abboud, J. Pitt, C. Diaz, I. C. Hanson, E. Cooper, H. Mendez

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Infants with perinatally acquired human immunodeficiency virus type 1 (HIV-1) infection have widely variable courses. Previous studies showed that a number of maternal and infant factors, when analyzed separately, are associated with infant HIV-1 disease progression. In this study, clincal, virologic, and immunologic characteristics in the mothers and infants were examined together to determine the predictors of disease progression by 18 months of age and the associations with rapid progression during the first 6 months of life. METHODS: One hundred twenty-two HIV-1-infected women whose infants were HIV-1 infected were identified from the Women and Infants Transmission Study (WITS) cohort. WITS is a longitudinal natural history study of perinatal HIV-1 infection carried out in 6 sites in the continental United States and in Puerto Rico. The women were enrolled during pregnancy and their infants were enrolled at the time of delivery and followed prospectively by a standardized protocol. Virologic and immunologic studies were performed in laboratories certified by National Institutes of Health-sponsored quality assurance programs. Maternal factors in pregnancy were used as potential predictors of infant disease progression (progression to Centers for Disease Control and Prevention [CDC] Clinical Class C disease or death by 18 months of age) or as correlates of progression at

Original languageEnglish (US)
JournalPediatrics
Volume105
Issue number1
StatePublished - Jan 2000
Externally publishedYes

Fingerprint

Disease Progression
HIV-1
Mothers
Virus Diseases
Puerto Rico
Pregnancy
National Institutes of Health (U.S.)
Centers for Disease Control and Prevention (U.S.)
Natural History
Cohort Studies

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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Maternal and infant factors predicting disease progression in human immunodeficiency virus type 1-infected infants. Women and Infants Transmission Study Group. / Rich, K. C.; Fowler, M. G.; Mofenson, L. M.; Abboud, R.; Pitt, J.; Diaz, C.; Hanson, I. C.; Cooper, E.; Mendez, H.

In: Pediatrics, Vol. 105, No. 1, 01.2000.

Research output: Contribution to journalArticle

Rich, K. C. ; Fowler, M. G. ; Mofenson, L. M. ; Abboud, R. ; Pitt, J. ; Diaz, C. ; Hanson, I. C. ; Cooper, E. ; Mendez, H. / Maternal and infant factors predicting disease progression in human immunodeficiency virus type 1-infected infants. Women and Infants Transmission Study Group. In: Pediatrics. 2000 ; Vol. 105, No. 1.
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