Maternal and fetal cytomegalovirus infection: Diagnosis, management, and prevention

Robert F. Pass, Ravit Arav-Boger

Research output: Contribution to journalReview articlepeer-review

Abstract

Congenital cytomegalovirus infection is a major cause of central nervous system and sensory impairments that affect cognition, motor function, hearing, language development, vestibular function, and vision. Although the importance of congenital cytomegalovirus infection is readily evident, the vast majority of maternal and fetal infections are not identified, even in developed countries. Multiple studies of prenatal cytomegalovirus infections have produced a body of knowledge that can inform the clinical approach to suspected or proven maternal and fetal infection. Reliable diagnosis of cytomegalovirus infection during pregnancy and accurate diagnosis of fetal infection are a reality. Approaches to preventing the transmission of cytomegalovirus from mother to fetus and to the treatment of fetal infection are being studied. There is evidence that public health approaches based on hygiene can dramatically reduce the rate of primary maternal cytomegalovirus infections during pregnancy. This review will consider the epidemiology of congenital cytomegalovirus infection, the diagnosis and management of primary infection during pregnancy, and approaches to preventing maternal infection.

Original languageEnglish (US)
Article number255
JournalF1000Research
Volume7
DOIs
StatePublished - 2018

Keywords

  • CMV hyperimmune globulin
  • CMV prevention
  • Congenital infection
  • Cytomegalovirus
  • Fetal diagnosis
  • Fetal infection
  • Prenatal infection
  • Valacyclovir

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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