Maté drinking and esophageal squamous cell carcinoma in South America: Pooled results from two large multicenter case-control studies

Jay H. Lubin, Eduardo De Stefani, Christian C. Abnet, Gisele Acosta, Paolo Boffetta, Cesar Victora, Barry I. Graubard, Nubia Muñoz, Hugo Deneo-Pellegrini, Silvia Franceschi, Xavier Castellsagué, Alvaro L. Ronco, Sanford M. Dawsey

Research output: Contribution to journalArticle

Abstract

Background: Maté tea is a nonalcoholic infusion widely consumed in southern South America, and may increase risk of esophageal squamous cell carcinoma (ESCC) and other cancers due to polycyclic aromatic hydrocarbons (PAH) and/or thermal injury. Methods: We pooled two case-control studies: a 1988 to 2005 Uruguay study and a 1986 to 1992multinational study in Argentina, Brazil, Paraguay, and Uruguay, including 1,400 cases and 3,229 controls. We computed ORs and fitted a linear excess OR (EOR) model for cumulative maté consumption in liters/day-year (LPDY). Results: The adjusted OR for ESCC with 95% confidence interval (CI) by ever compared with never use of maté was 1.60 (1.2-2.2). ORs increased linearly with LPDY (test of nonlinearity; P=0.69). The estimate of slope (EOR/LPDY) was 0.009 (0.005-0.014) and did not vary with daily intake, indicating maté intensity did not influence the strength of association. EOR/LPDY estimates for consumption at warm, hot, and very hot beverage temperatures were 0.004 (-0.002-0.013), 0.007 (0.003-0.013), and 0.016 (0.009-0.027), respectively, and differed significantly (P <0.01). EOR/LPDY estimates were increased in younger (

Original languageEnglish (US)
Pages (from-to)107-116
Number of pages10
JournalCancer Epidemiology Biomarkers and Prevention
Volume23
Issue number1
DOIs
StatePublished - Jan 2014
Externally publishedYes

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Uruguay
South America
Drinking
Case-Control Studies
Hot Temperature
Paraguay
Polycyclic Aromatic Hydrocarbons
Argentina
Beverages
Tea
Brazil
Confidence Intervals
Wounds and Injuries
Neoplasms
Esophageal Squamous Cell Carcinoma

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Maté drinking and esophageal squamous cell carcinoma in South America : Pooled results from two large multicenter case-control studies. / Lubin, Jay H.; De Stefani, Eduardo; Abnet, Christian C.; Acosta, Gisele; Boffetta, Paolo; Victora, Cesar; Graubard, Barry I.; Muñoz, Nubia; Deneo-Pellegrini, Hugo; Franceschi, Silvia; Castellsagué, Xavier; Ronco, Alvaro L.; Dawsey, Sanford M.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 23, No. 1, 01.2014, p. 107-116.

Research output: Contribution to journalArticle

Lubin, JH, De Stefani, E, Abnet, CC, Acosta, G, Boffetta, P, Victora, C, Graubard, BI, Muñoz, N, Deneo-Pellegrini, H, Franceschi, S, Castellsagué, X, Ronco, AL & Dawsey, SM 2014, 'Maté drinking and esophageal squamous cell carcinoma in South America: Pooled results from two large multicenter case-control studies', Cancer Epidemiology Biomarkers and Prevention, vol. 23, no. 1, pp. 107-116. https://doi.org/10.1158/1055-9965.EPI-13-0796
Lubin, Jay H. ; De Stefani, Eduardo ; Abnet, Christian C. ; Acosta, Gisele ; Boffetta, Paolo ; Victora, Cesar ; Graubard, Barry I. ; Muñoz, Nubia ; Deneo-Pellegrini, Hugo ; Franceschi, Silvia ; Castellsagué, Xavier ; Ronco, Alvaro L. ; Dawsey, Sanford M. / Maté drinking and esophageal squamous cell carcinoma in South America : Pooled results from two large multicenter case-control studies. In: Cancer Epidemiology Biomarkers and Prevention. 2014 ; Vol. 23, No. 1. pp. 107-116.
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abstract = "Background: Mat{\'e} tea is a nonalcoholic infusion widely consumed in southern South America, and may increase risk of esophageal squamous cell carcinoma (ESCC) and other cancers due to polycyclic aromatic hydrocarbons (PAH) and/or thermal injury. Methods: We pooled two case-control studies: a 1988 to 2005 Uruguay study and a 1986 to 1992multinational study in Argentina, Brazil, Paraguay, and Uruguay, including 1,400 cases and 3,229 controls. We computed ORs and fitted a linear excess OR (EOR) model for cumulative mat{\'e} consumption in liters/day-year (LPDY). Results: The adjusted OR for ESCC with 95{\%} confidence interval (CI) by ever compared with never use of mat{\'e} was 1.60 (1.2-2.2). ORs increased linearly with LPDY (test of nonlinearity; P=0.69). The estimate of slope (EOR/LPDY) was 0.009 (0.005-0.014) and did not vary with daily intake, indicating mat{\'e} intensity did not influence the strength of association. EOR/LPDY estimates for consumption at warm, hot, and very hot beverage temperatures were 0.004 (-0.002-0.013), 0.007 (0.003-0.013), and 0.016 (0.009-0.027), respectively, and differed significantly (P <0.01). EOR/LPDY estimates were increased in younger (",
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T1 - Maté drinking and esophageal squamous cell carcinoma in South America

T2 - Pooled results from two large multicenter case-control studies

AU - Lubin, Jay H.

AU - De Stefani, Eduardo

AU - Abnet, Christian C.

AU - Acosta, Gisele

AU - Boffetta, Paolo

AU - Victora, Cesar

AU - Graubard, Barry I.

AU - Muñoz, Nubia

AU - Deneo-Pellegrini, Hugo

AU - Franceschi, Silvia

AU - Castellsagué, Xavier

AU - Ronco, Alvaro L.

AU - Dawsey, Sanford M.

PY - 2014/1

Y1 - 2014/1

N2 - Background: Maté tea is a nonalcoholic infusion widely consumed in southern South America, and may increase risk of esophageal squamous cell carcinoma (ESCC) and other cancers due to polycyclic aromatic hydrocarbons (PAH) and/or thermal injury. Methods: We pooled two case-control studies: a 1988 to 2005 Uruguay study and a 1986 to 1992multinational study in Argentina, Brazil, Paraguay, and Uruguay, including 1,400 cases and 3,229 controls. We computed ORs and fitted a linear excess OR (EOR) model for cumulative maté consumption in liters/day-year (LPDY). Results: The adjusted OR for ESCC with 95% confidence interval (CI) by ever compared with never use of maté was 1.60 (1.2-2.2). ORs increased linearly with LPDY (test of nonlinearity; P=0.69). The estimate of slope (EOR/LPDY) was 0.009 (0.005-0.014) and did not vary with daily intake, indicating maté intensity did not influence the strength of association. EOR/LPDY estimates for consumption at warm, hot, and very hot beverage temperatures were 0.004 (-0.002-0.013), 0.007 (0.003-0.013), and 0.016 (0.009-0.027), respectively, and differed significantly (P <0.01). EOR/LPDY estimates were increased in younger (

AB - Background: Maté tea is a nonalcoholic infusion widely consumed in southern South America, and may increase risk of esophageal squamous cell carcinoma (ESCC) and other cancers due to polycyclic aromatic hydrocarbons (PAH) and/or thermal injury. Methods: We pooled two case-control studies: a 1988 to 2005 Uruguay study and a 1986 to 1992multinational study in Argentina, Brazil, Paraguay, and Uruguay, including 1,400 cases and 3,229 controls. We computed ORs and fitted a linear excess OR (EOR) model for cumulative maté consumption in liters/day-year (LPDY). Results: The adjusted OR for ESCC with 95% confidence interval (CI) by ever compared with never use of maté was 1.60 (1.2-2.2). ORs increased linearly with LPDY (test of nonlinearity; P=0.69). The estimate of slope (EOR/LPDY) was 0.009 (0.005-0.014) and did not vary with daily intake, indicating maté intensity did not influence the strength of association. EOR/LPDY estimates for consumption at warm, hot, and very hot beverage temperatures were 0.004 (-0.002-0.013), 0.007 (0.003-0.013), and 0.016 (0.009-0.027), respectively, and differed significantly (P <0.01). EOR/LPDY estimates were increased in younger (

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