Abstract
Background: Maté tea is a nonalcoholic infusion widely consumed in southern South America, and may increase risk of esophageal squamous cell carcinoma (ESCC) and other cancers due to polycyclic aromatic hydrocarbons (PAH) and/or thermal injury. Methods: We pooled two case-control studies: a 1988 to 2005 Uruguay study and a 1986 to 1992multinational study in Argentina, Brazil, Paraguay, and Uruguay, including 1,400 cases and 3,229 controls. We computed ORs and fitted a linear excess OR (EOR) model for cumulative maté consumption in liters/day-year (LPDY). Results: The adjusted OR for ESCC with 95% confidence interval (CI) by ever compared with never use of maté was 1.60 (1.2-2.2). ORs increased linearly with LPDY (test of nonlinearity; P=0.69). The estimate of slope (EOR/LPDY) was 0.009 (0.005-0.014) and did not vary with daily intake, indicating maté intensity did not influence the strength of association. EOR/LPDY estimates for consumption at warm, hot, and very hot beverage temperatures were 0.004 (-0.002-0.013), 0.007 (0.003-0.013), and 0.016 (0.009-0.027), respectively, and differed significantly (P <0.01). EOR/LPDY estimates were increased in younger (
| Original language | English (US) |
|---|---|
| Pages (from-to) | 107-116 |
| Number of pages | 10 |
| Journal | Cancer Epidemiology Biomarkers and Prevention |
| Volume | 23 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2014 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Epidemiology
- Oncology
Cite this
Maté drinking and esophageal squamous cell carcinoma in South America : Pooled results from two large multicenter case-control studies. / Lubin, Jay H.; De Stefani, Eduardo; Abnet, Christian C.; Acosta, Gisele; Boffetta, Paolo; Victora, Cesar; Graubard, Barry I.; Muñoz, Nubia; Deneo-Pellegrini, Hugo; Franceschi, Silvia; Castellsagué, Xavier; Ronco, Alvaro L.; Dawsey, Sanford M.
In: Cancer Epidemiology Biomarkers and Prevention, Vol. 23, No. 1, 01.2014, p. 107-116.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Maté drinking and esophageal squamous cell carcinoma in South America
T2 - Pooled results from two large multicenter case-control studies
AU - Lubin, Jay H.
AU - De Stefani, Eduardo
AU - Abnet, Christian C.
AU - Acosta, Gisele
AU - Boffetta, Paolo
AU - Victora, Cesar
AU - Graubard, Barry I.
AU - Muñoz, Nubia
AU - Deneo-Pellegrini, Hugo
AU - Franceschi, Silvia
AU - Castellsagué, Xavier
AU - Ronco, Alvaro L.
AU - Dawsey, Sanford M.
PY - 2014/1
Y1 - 2014/1
N2 - Background: Maté tea is a nonalcoholic infusion widely consumed in southern South America, and may increase risk of esophageal squamous cell carcinoma (ESCC) and other cancers due to polycyclic aromatic hydrocarbons (PAH) and/or thermal injury. Methods: We pooled two case-control studies: a 1988 to 2005 Uruguay study and a 1986 to 1992multinational study in Argentina, Brazil, Paraguay, and Uruguay, including 1,400 cases and 3,229 controls. We computed ORs and fitted a linear excess OR (EOR) model for cumulative maté consumption in liters/day-year (LPDY). Results: The adjusted OR for ESCC with 95% confidence interval (CI) by ever compared with never use of maté was 1.60 (1.2-2.2). ORs increased linearly with LPDY (test of nonlinearity; P=0.69). The estimate of slope (EOR/LPDY) was 0.009 (0.005-0.014) and did not vary with daily intake, indicating maté intensity did not influence the strength of association. EOR/LPDY estimates for consumption at warm, hot, and very hot beverage temperatures were 0.004 (-0.002-0.013), 0.007 (0.003-0.013), and 0.016 (0.009-0.027), respectively, and differed significantly (P <0.01). EOR/LPDY estimates were increased in younger (
AB - Background: Maté tea is a nonalcoholic infusion widely consumed in southern South America, and may increase risk of esophageal squamous cell carcinoma (ESCC) and other cancers due to polycyclic aromatic hydrocarbons (PAH) and/or thermal injury. Methods: We pooled two case-control studies: a 1988 to 2005 Uruguay study and a 1986 to 1992multinational study in Argentina, Brazil, Paraguay, and Uruguay, including 1,400 cases and 3,229 controls. We computed ORs and fitted a linear excess OR (EOR) model for cumulative maté consumption in liters/day-year (LPDY). Results: The adjusted OR for ESCC with 95% confidence interval (CI) by ever compared with never use of maté was 1.60 (1.2-2.2). ORs increased linearly with LPDY (test of nonlinearity; P=0.69). The estimate of slope (EOR/LPDY) was 0.009 (0.005-0.014) and did not vary with daily intake, indicating maté intensity did not influence the strength of association. EOR/LPDY estimates for consumption at warm, hot, and very hot beverage temperatures were 0.004 (-0.002-0.013), 0.007 (0.003-0.013), and 0.016 (0.009-0.027), respectively, and differed significantly (P <0.01). EOR/LPDY estimates were increased in younger (
UR - http://www.scopus.com/inward/record.url?scp=84892699623&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84892699623&partnerID=8YFLogxK
U2 - 10.1158/1055-9965.EPI-13-0796
DO - 10.1158/1055-9965.EPI-13-0796
M3 - Article
C2 - 24130226
AN - SCOPUS:84892699623
VL - 23
SP - 107
EP - 116
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
SN - 1055-9965
IS - 1
ER -