Mast cell transcriptional networks

Clifford M. Takemoto; Youl Nam Lee; Anil G. Jegga; Daniella Zablocki; Stephanie Brandal; Amir Shahlaee; Suming Huang; Ying Ye; Sivakumar Gowrisankar; Jimmy Huynh; Michael A. McDevitt

doi:10.1016/j.bcmd.2008.02.005

Mast cell transcriptional networks

Clifford M. Takemoto, Youl Nam Lee, Anil G. Jegga, Daniella Zablocki, Stephanie Brandal, Amir Shahlaee, Suming Huang, Ying Ye, Sivakumar Gowrisankar, Jimmy Huynh, Michael A. McDevitt

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Unregulated activation of mast cells can contribute to the pathogenesis of inflammatory and allergic diseases, including asthma, rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis. Absence of mast cells in animal models can lead to impairment in the innate immune response to parasites and bacterial infections. Aberrant clonal accumulation and proliferation of mast cells can result in a variety of diseases ranging from benign cutaneous mastocytosis to systemic mastocytosis or mast cell leukemia. Understanding mast cell differentiation provides important insights into mechanisms of lineage selection during hematopoiesis and can provide targets for new drug development to treat mast cell disorders. In this review, we discuss controversies related to development, sites of origin, and the transcriptional program of mast cells.

Original language	English (US)
Pages (from-to)	82-90
Number of pages	9
Journal	Blood Cells, Molecules, and Diseases
Volume	41
Issue number	1
DOIs	https://doi.org/10.1016/j.bcmd.2008.02.005
State	Published - Jul 1 2008

Keywords

GATA
Mast cells
Mitf
PU.1
Transcription factors

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Hematology
Cell Biology

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10.1016/j.bcmd.2008.02.005

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Mast cell transcriptional networks. / Takemoto, Clifford M.; Lee, Youl Nam; Jegga, Anil G.; Zablocki, Daniella; Brandal, Stephanie; Shahlaee, Amir; Huang, Suming; Ye, Ying; Gowrisankar, Sivakumar; Huynh, Jimmy; McDevitt, Michael A.

In: Blood Cells, Molecules, and Diseases, Vol. 41, No. 1, 01.07.2008, p. 82-90.

Research output: Contribution to journal › Article › peer-review

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