TY - JOUR
T1 - Mast cell transcriptional networks
AU - Takemoto, Clifford M.
AU - Lee, Youl Nam
AU - Jegga, Anil G.
AU - Zablocki, Daniella
AU - Brandal, Stephanie
AU - Shahlaee, Amir
AU - Huang, Suming
AU - Ye, Ying
AU - Gowrisankar, Sivakumar
AU - Huynh, Jimmy
AU - McDevitt, Michael A.
PY - 2008/7/1
Y1 - 2008/7/1
N2 - Unregulated activation of mast cells can contribute to the pathogenesis of inflammatory and allergic diseases, including asthma, rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis. Absence of mast cells in animal models can lead to impairment in the innate immune response to parasites and bacterial infections. Aberrant clonal accumulation and proliferation of mast cells can result in a variety of diseases ranging from benign cutaneous mastocytosis to systemic mastocytosis or mast cell leukemia. Understanding mast cell differentiation provides important insights into mechanisms of lineage selection during hematopoiesis and can provide targets for new drug development to treat mast cell disorders. In this review, we discuss controversies related to development, sites of origin, and the transcriptional program of mast cells.
AB - Unregulated activation of mast cells can contribute to the pathogenesis of inflammatory and allergic diseases, including asthma, rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis. Absence of mast cells in animal models can lead to impairment in the innate immune response to parasites and bacterial infections. Aberrant clonal accumulation and proliferation of mast cells can result in a variety of diseases ranging from benign cutaneous mastocytosis to systemic mastocytosis or mast cell leukemia. Understanding mast cell differentiation provides important insights into mechanisms of lineage selection during hematopoiesis and can provide targets for new drug development to treat mast cell disorders. In this review, we discuss controversies related to development, sites of origin, and the transcriptional program of mast cells.
KW - GATA
KW - Mast cells
KW - Mitf
KW - PU.1
KW - Transcription factors
UR - http://www.scopus.com/inward/record.url?scp=44449172898&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=44449172898&partnerID=8YFLogxK
U2 - 10.1016/j.bcmd.2008.02.005
DO - 10.1016/j.bcmd.2008.02.005
M3 - Article
C2 - 18406636
AN - SCOPUS:44449172898
VL - 41
SP - 82
EP - 90
JO - Blood Cells, Molecules, and Diseases
JF - Blood Cells, Molecules, and Diseases
SN - 1079-9796
IS - 1
ER -