Mast cell transcriptional networks

Clifford M. Takemoto, Youl Nam Lee, Anil G. Jegga, Daniella Zablocki, Stephanie Brandal, Amir Shahlaee, Suming Huang, Ying Ye, Sivakumar Gowrisankar, Jimmy Huynh, Michael A. McDevitt

Research output: Contribution to journalArticlepeer-review


Unregulated activation of mast cells can contribute to the pathogenesis of inflammatory and allergic diseases, including asthma, rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis. Absence of mast cells in animal models can lead to impairment in the innate immune response to parasites and bacterial infections. Aberrant clonal accumulation and proliferation of mast cells can result in a variety of diseases ranging from benign cutaneous mastocytosis to systemic mastocytosis or mast cell leukemia. Understanding mast cell differentiation provides important insights into mechanisms of lineage selection during hematopoiesis and can provide targets for new drug development to treat mast cell disorders. In this review, we discuss controversies related to development, sites of origin, and the transcriptional program of mast cells.

Original languageEnglish (US)
Pages (from-to)82-90
Number of pages9
JournalBlood Cells, Molecules, and Diseases
Issue number1
StatePublished - Jul 1 2008


  • GATA
  • Mast cells
  • Mitf
  • PU.1
  • Transcription factors

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Hematology
  • Cell Biology

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