TY - JOUR
T1 - Mast cell transcriptional networks
AU - Takemoto, Clifford M.
AU - Lee, Youl Nam
AU - Jegga, Anil G.
AU - Zablocki, Daniella
AU - Brandal, Stephanie
AU - Shahlaee, Amir
AU - Huang, Suming
AU - Ye, Ying
AU - Gowrisankar, Sivakumar
AU - Huynh, Jimmy
AU - McDevitt, Michael A.
N1 - Funding Information:
This article is based on a presentation at the Seventh International Workshop on Molecular Aspects of Myeloid Stem Cell Development and Leukemia in Annapolis, Maryland on May 13–16, 2007, sponsored by the Leukemia and Lymphoma Society. We thank Amy Laliberte for excellent technical assistance. MAM was supported by DOD #MPO48018 and JHUSOPH Malaria Institute. CMT was supported in part by the Basil O'Conner Starter Scholar Research Award Grant 5-FR04-30 from the March of Dimes Birth Defects Foundation; a Children's Cancer Foundation Grant; and National Institutes of Health Grant 5R01HL077178.
PY - 2008/7
Y1 - 2008/7
N2 - Unregulated activation of mast cells can contribute to the pathogenesis of inflammatory and allergic diseases, including asthma, rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis. Absence of mast cells in animal models can lead to impairment in the innate immune response to parasites and bacterial infections. Aberrant clonal accumulation and proliferation of mast cells can result in a variety of diseases ranging from benign cutaneous mastocytosis to systemic mastocytosis or mast cell leukemia. Understanding mast cell differentiation provides important insights into mechanisms of lineage selection during hematopoiesis and can provide targets for new drug development to treat mast cell disorders. In this review, we discuss controversies related to development, sites of origin, and the transcriptional program of mast cells.
AB - Unregulated activation of mast cells can contribute to the pathogenesis of inflammatory and allergic diseases, including asthma, rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis. Absence of mast cells in animal models can lead to impairment in the innate immune response to parasites and bacterial infections. Aberrant clonal accumulation and proliferation of mast cells can result in a variety of diseases ranging from benign cutaneous mastocytosis to systemic mastocytosis or mast cell leukemia. Understanding mast cell differentiation provides important insights into mechanisms of lineage selection during hematopoiesis and can provide targets for new drug development to treat mast cell disorders. In this review, we discuss controversies related to development, sites of origin, and the transcriptional program of mast cells.
KW - GATA
KW - Mast cells
KW - Mitf
KW - PU.1
KW - Transcription factors
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U2 - 10.1016/j.bcmd.2008.02.005
DO - 10.1016/j.bcmd.2008.02.005
M3 - Article
C2 - 18406636
AN - SCOPUS:44449172898
SN - 1079-9796
VL - 41
SP - 82
EP - 90
JO - Blood Cells, Molecules, and Diseases
JF - Blood Cells, Molecules, and Diseases
IS - 1
ER -