Massive splenomegaly correlates with malignancy

180 cases of splenic littoral cell tumors in the world literature

J. J. Sarandria, M. Escano, F. Kamangar, S. O. Farooqui, Elizabeth A Montgomery, S. C. Cunningham

Research output: Contribution to journalArticle

Abstract

Littoral cell tumors (LCT) are rare primary splenic neoplasms, unique for their morphologic and immunolabeling features resembling the endothelial littoral cells lining the sinusoids of the red pulp. They include the more common and typically benign littoral cell angioma, as 'well as the less common, potentially malignant, littoral cell hemangioendothelioma (LCHE) and the aggressive littoral cell angiosarcoma (LCAS). The most common presentation of these neoplasms is splenomegaly, and diagnosis is made histologically following biopsy or resection. To better understand these tumors, a comprehensive, international literature search was performed. Patient and tumor data, including presenting symptoms, comorbid cancers, immunosuppressive states, splenic mass and tumor size were analyzed. Massive splenomegaly (≥1500 g) following splenic resection, which correlates with a splenic length of 20 cm preoperatively, was found to be significantly associated with the presence of malignancy in the LCT (P

Original languageEnglish (US)
Pages (from-to)229-237
Number of pages9
JournalMinerva Chirurgica
Volume69
Issue number4
StatePublished - 2014

Fingerprint

Splenomegaly
Neoplasms
Splenic Neoplasms
Hemangioendothelioma
Hemangiosarcoma
Immunosuppressive Agents
Endothelial Cells
Biopsy

Keywords

  • Crohn disease
  • Hemangioendothelioma
  • Hemangiosarcoma
  • Littoral cell angioma of the spleen
  • Spleen

ASJC Scopus subject areas

  • Surgery
  • Medicine(all)

Cite this

Sarandria, J. J., Escano, M., Kamangar, F., Farooqui, S. O., Montgomery, E. A., & Cunningham, S. C. (2014). Massive splenomegaly correlates with malignancy: 180 cases of splenic littoral cell tumors in the world literature. Minerva Chirurgica, 69(4), 229-237.

Massive splenomegaly correlates with malignancy : 180 cases of splenic littoral cell tumors in the world literature. / Sarandria, J. J.; Escano, M.; Kamangar, F.; Farooqui, S. O.; Montgomery, Elizabeth A; Cunningham, S. C.

In: Minerva Chirurgica, Vol. 69, No. 4, 2014, p. 229-237.

Research output: Contribution to journalArticle

Sarandria, JJ, Escano, M, Kamangar, F, Farooqui, SO, Montgomery, EA & Cunningham, SC 2014, 'Massive splenomegaly correlates with malignancy: 180 cases of splenic littoral cell tumors in the world literature', Minerva Chirurgica, vol. 69, no. 4, pp. 229-237.
Sarandria, J. J. ; Escano, M. ; Kamangar, F. ; Farooqui, S. O. ; Montgomery, Elizabeth A ; Cunningham, S. C. / Massive splenomegaly correlates with malignancy : 180 cases of splenic littoral cell tumors in the world literature. In: Minerva Chirurgica. 2014 ; Vol. 69, No. 4. pp. 229-237.
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