Massive Retinal Gliosis

A Reactive Proliferation of Müller Cells

T. Michael Nork, Mona W. Ghobrial, Gholam A. Peyman, Mark O M Tso

Research output: Contribution to journalArticle

Abstract

Both Müller cells and astrocytes have been implicated in the dispute over the histogenesis of massive retinal gliosis. We studied three cases of massive retinal gliosis by light and electron microscopy and immunocytochemistry. Spindle fibrillary glial cells were joined by zonulae adherentes resembling those of the external limiting membrane of the retina. Furthermore, these cells produced a continuous basement membrane around an extracellular space filled with fine filaments, which was highly suggestive of vitreous cavity. In the proliferating cells, immunoperoxidase technique disclosed the presence of carbonic anhydrase isoenzyme C, characteristically found only in Müller cells. The glial cells in the preretinal membrane away from the gliotic nodule showed similar characteristics. We concluded that both the nodule of massive retinal gliosis and the associated preretinal glial membrane resulted from the proliferation and migration of Müller cells.

Original languageEnglish (US)
Pages (from-to)1383-1389
Number of pages7
JournalArchives of Ophthalmology
Volume104
Issue number9
DOIs
StatePublished - 1986

Fingerprint

Gliosis
Cell Proliferation
Neuroglia
Membranes
Carbonic Anhydrase II
Dissent and Disputes
Extracellular Space
Immunoenzyme Techniques
Basement Membrane
Astrocytes
Cell Movement
Retina
Electron Microscopy
Immunohistochemistry
Light

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Massive Retinal Gliosis : A Reactive Proliferation of Müller Cells. / Nork, T. Michael; Ghobrial, Mona W.; Peyman, Gholam A.; Tso, Mark O M.

In: Archives of Ophthalmology, Vol. 104, No. 9, 1986, p. 1383-1389.

Research output: Contribution to journalArticle

Nork, T. Michael ; Ghobrial, Mona W. ; Peyman, Gholam A. ; Tso, Mark O M. / Massive Retinal Gliosis : A Reactive Proliferation of Müller Cells. In: Archives of Ophthalmology. 1986 ; Vol. 104, No. 9. pp. 1383-1389.
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