TY - JOUR
T1 - Massive localized lymphedema revisited
T2 - A quickly rising complication of the obesity epidemic
AU - Chopra, Karan
AU - Tadisina, Kashyap K.
AU - Brewer, Michael
AU - Holton, Luther H.
AU - Banda, Abhishake K.
AU - Singh, Devinder P.
N1 - Publisher Copyright:
Copyright © 2013 by Lippincott Williams & Wilkins.
PY - 2015
Y1 - 2015
N2 - Massive localized lymphedema (MLL) is a rising and potentially fatal complication of the obesity epidemic. Described as a benign lymphoproliferative overgrowth of obese patients, MLL is a form of secondary lymphedema, caused by the obstruction of lymphatic f low, with characteristic clinical and histological presentation. Patients have a large mass with classic skin changes often accompanied by lymphatic weeping that require complex reconstruction. Although oftentimes benign, if left untreated, MLL can progress to angiosarcoma, further supporting the need for more research into MLL and its sequelae. We present a unique case of MLL of the mons pubis in a 52-year-old man with a body mass index of 75.7 kg/m2. The literature was comprehensively reviewed with a total of 65 cases of MLL being described, 9 of which resulted in angiosarcoma (10.3% of all cases), 6 of which resulted in death (9.2% of all cases). We found a female predominance of 1.24 to 1, an average weight of 183 kg, and a 48.5% majority of cases in the thigh.
AB - Massive localized lymphedema (MLL) is a rising and potentially fatal complication of the obesity epidemic. Described as a benign lymphoproliferative overgrowth of obese patients, MLL is a form of secondary lymphedema, caused by the obstruction of lymphatic f low, with characteristic clinical and histological presentation. Patients have a large mass with classic skin changes often accompanied by lymphatic weeping that require complex reconstruction. Although oftentimes benign, if left untreated, MLL can progress to angiosarcoma, further supporting the need for more research into MLL and its sequelae. We present a unique case of MLL of the mons pubis in a 52-year-old man with a body mass index of 75.7 kg/m2. The literature was comprehensively reviewed with a total of 65 cases of MLL being described, 9 of which resulted in angiosarcoma (10.3% of all cases), 6 of which resulted in death (9.2% of all cases). We found a female predominance of 1.24 to 1, an average weight of 183 kg, and a 48.5% majority of cases in the thigh.
KW - Angiosarcoma
KW - Lymphedema of obesity
KW - MLL
KW - Massive localized lymphedema
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U2 - 10.1097/SAP.0b013e31828bb332
DO - 10.1097/SAP.0b013e31828bb332
M3 - Review article
C2 - 23722582
AN - SCOPUS:84924978466
SN - 0148-7043
VL - 74
SP - 126
EP - 132
JO - Annals of plastic surgery
JF - Annals of plastic surgery
IS - 1
ER -