Mass Oral Azithromycin for Childhood Mortality: Timing of Death After Distribution in the MORDOR Trial

Macrolides Oraux pour Réduire les Décès avec un Oeil sur la Résistance (MORDOR) Study Group

Research output: Contribution to journalArticle

Abstract

In a large community-randomized trial, biannual azithromycin distributions significantly reduced postneonatal childhood mortality in sub-Saharan African sites. Here, we present a prespecified secondary analysis showing that much of the protective effect was in the first 3 months postdistribution. Distributing more frequently than biannually could be considered if logistically feasible. Clinical Trials Registration. NCT02047981.

Original languageEnglish (US)
Pages (from-to)2114-2116
Number of pages3
JournalClinical infectious diseases : an official publication of the Infectious Diseases Society of America
Volume68
Issue number12
DOIs
StatePublished - May 30 2019

Fingerprint

Azithromycin
Infant Mortality
Clinical Trials
Mortality

Keywords

  • azithromycin
  • childhood mortality
  • sub-Saharan Africa

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Mass Oral Azithromycin for Childhood Mortality : Timing of Death After Distribution in the MORDOR Trial. / Macrolides Oraux pour Réduire les Décès avec un Oeil sur la Résistance (MORDOR) Study Group.

In: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Vol. 68, No. 12, 30.05.2019, p. 2114-2116.

Research output: Contribution to journalArticle

Macrolides Oraux pour Réduire les Décès avec un Oeil sur la Résistance (MORDOR) Study Group. / Mass Oral Azithromycin for Childhood Mortality : Timing of Death After Distribution in the MORDOR Trial. In: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2019 ; Vol. 68, No. 12. pp. 2114-2116.
@article{52f4af07cadf41b2aeb39711cda30ab9,
title = "Mass Oral Azithromycin for Childhood Mortality: Timing of Death After Distribution in the MORDOR Trial",
abstract = "In a large community-randomized trial, biannual azithromycin distributions significantly reduced postneonatal childhood mortality in sub-Saharan African sites. Here, we present a prespecified secondary analysis showing that much of the protective effect was in the first 3 months postdistribution. Distributing more frequently than biannually could be considered if logistically feasible. Clinical Trials Registration. NCT02047981.",
keywords = "azithromycin, childhood mortality, sub-Saharan Africa",
author = "{Macrolides Oraux pour R{\'e}duire les D{\'e}c{\`e}s avec un Oeil sur la R{\'e}sistance (MORDOR) Study Group} and Porco, {Travis C.} and John Hart and Arzika, {Ahmed M.} and Jerusha Weaver and Khumbo Kalua and Zakayo Mrango and Cotter, {Sun Y.} and Stoller, {Nicole E.} and O'Brien, {Kieran S.} and Fry, {Dionna M.} and Benjamin Vanderschelden and Oldenburg, {Catherine E.} and West, {Sheila K} and Bailey, {Robin L.} and Keenan, {Jeremy D.} and Lietman, {Thomas M.}",
year = "2019",
month = "5",
day = "30",
doi = "10.1093/cid/ciy973",
language = "English (US)",
volume = "68",
pages = "2114--2116",
journal = "Clinical Infectious Diseases",
issn = "1058-4838",
publisher = "Oxford University Press",
number = "12",

}

TY - JOUR

T1 - Mass Oral Azithromycin for Childhood Mortality

T2 - Timing of Death After Distribution in the MORDOR Trial

AU - Macrolides Oraux pour Réduire les Décès avec un Oeil sur la Résistance (MORDOR) Study Group

AU - Porco, Travis C.

AU - Hart, John

AU - Arzika, Ahmed M.

AU - Weaver, Jerusha

AU - Kalua, Khumbo

AU - Mrango, Zakayo

AU - Cotter, Sun Y.

AU - Stoller, Nicole E.

AU - O'Brien, Kieran S.

AU - Fry, Dionna M.

AU - Vanderschelden, Benjamin

AU - Oldenburg, Catherine E.

AU - West, Sheila K

AU - Bailey, Robin L.

AU - Keenan, Jeremy D.

AU - Lietman, Thomas M.

PY - 2019/5/30

Y1 - 2019/5/30

N2 - In a large community-randomized trial, biannual azithromycin distributions significantly reduced postneonatal childhood mortality in sub-Saharan African sites. Here, we present a prespecified secondary analysis showing that much of the protective effect was in the first 3 months postdistribution. Distributing more frequently than biannually could be considered if logistically feasible. Clinical Trials Registration. NCT02047981.

AB - In a large community-randomized trial, biannual azithromycin distributions significantly reduced postneonatal childhood mortality in sub-Saharan African sites. Here, we present a prespecified secondary analysis showing that much of the protective effect was in the first 3 months postdistribution. Distributing more frequently than biannually could be considered if logistically feasible. Clinical Trials Registration. NCT02047981.

KW - azithromycin

KW - childhood mortality

KW - sub-Saharan Africa

UR - http://www.scopus.com/inward/record.url?scp=85067281482&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85067281482&partnerID=8YFLogxK

U2 - 10.1093/cid/ciy973

DO - 10.1093/cid/ciy973

M3 - Article

C2 - 30561577

AN - SCOPUS:85067281482

VL - 68

SP - 2114

EP - 2116

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

SN - 1058-4838

IS - 12

ER -