TY - JOUR
T1 - Mass-correlated pulsed extraction
T2 - Theoretical analysis and implementation with a linear matrix-assisted laser desorption/ionization time of flight mass spectrometer
AU - Kovtoun, Slava V.
AU - Cotter, Robert J.
PY - 2000/12/1
Y1 - 2000/12/1
N2 - The pulsed extraction (PE) of ions produced by matrix-assisted laser desorption/ionization in time-of-flight mass spectrometers greatly improves mass resolution but, unfortunately, this method is mass dependent. Here we report an approach to expand the capabilities of the PE method so as to provide uniform focusing conditions over a wide mass range. Along with an extraction pulse, an additional pulse is applied to correct the mass dependency of the standard PE method. We describe the algorithm for derivation of this correction pulse waveform, where the first-order focusing conditions are valid all along the mass region of interest. Experimental verification of this method for correction of ion velocities demonstrated better mass resolution than standard PE over a wide mass range.
AB - The pulsed extraction (PE) of ions produced by matrix-assisted laser desorption/ionization in time-of-flight mass spectrometers greatly improves mass resolution but, unfortunately, this method is mass dependent. Here we report an approach to expand the capabilities of the PE method so as to provide uniform focusing conditions over a wide mass range. Along with an extraction pulse, an additional pulse is applied to correct the mass dependency of the standard PE method. We describe the algorithm for derivation of this correction pulse waveform, where the first-order focusing conditions are valid all along the mass region of interest. Experimental verification of this method for correction of ion velocities demonstrated better mass resolution than standard PE over a wide mass range.
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U2 - 10.1016/S1044-0305(00)00165-3
DO - 10.1016/S1044-0305(00)00165-3
M3 - Article
C2 - 11014446
AN - SCOPUS:0034478590
SN - 1044-0305
VL - 11
SP - 841
EP - 853
JO - Journal of the American Society for Mass Spectrometry
JF - Journal of the American Society for Mass Spectrometry
IS - 10
ER -