Masquerade scleritis

Chrysanthi Kafkala, Yassine Daoud, Ian Paredes, C. Stephen Foster

Research output: Contribution to journalArticle

Abstract

Purpose: To report two cases in which malignancy masqueraded as scleritis, delaying the diagnosis. Methods: Two patients initially diagnosed and treated for unilateral scleritis were referred for management of persistent inflammation. Additional evaluation uncovered underlying malignant processes. Results: The first patient presented with scleritis initially responsive to systemic corticosteroids, with relapse one month later. Upon referral, peripheral fundus examination revealed elevated lesions. Additional studies confirmed the diagnosis of choroidal melanoma. The patient was treated with proton-beam irradiation. The second patient developed necrotizing scleritis unresponsive to systemic steroids, methotrexate, and cyclophosphamide. A scleral biopsy disclosed an undifferentiated high-grade carcinoma, likely metastatic. Exenteration was performed. Conclusions: Scleritis can present a diagnostic challenge. It is often the sole initial manifestation of an occult systemic problem. Treatment-resistant scleritis should raise the suspicion of an infectious or malignant masquerade.

Original languageEnglish (US)
Pages (from-to)479-482
Number of pages4
JournalOcular Immunology and Inflammation
Volume13
Issue number6
DOIs
StatePublished - Dec 2005
Externally publishedYes

Fingerprint

Scleritis
Methotrexate
Cyclophosphamide
Protons
Melanoma
Adrenal Cortex Hormones
Referral and Consultation
Steroids
Inflammation
Carcinoma
Biopsy
Recurrence

Keywords

  • Metastatic ocular carcinoma
  • Scleritis
  • Uveal melanoma

ASJC Scopus subject areas

  • Ophthalmology
  • Immunology and Allergy

Cite this

Masquerade scleritis. / Kafkala, Chrysanthi; Daoud, Yassine; Paredes, Ian; Foster, C. Stephen.

In: Ocular Immunology and Inflammation, Vol. 13, No. 6, 12.2005, p. 479-482.

Research output: Contribution to journalArticle

Kafkala, C, Daoud, Y, Paredes, I & Foster, CS 2005, 'Masquerade scleritis', Ocular Immunology and Inflammation, vol. 13, no. 6, pp. 479-482. https://doi.org/10.1080/09273940591004133
Kafkala, Chrysanthi ; Daoud, Yassine ; Paredes, Ian ; Foster, C. Stephen. / Masquerade scleritis. In: Ocular Immunology and Inflammation. 2005 ; Vol. 13, No. 6. pp. 479-482.
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