Masking of the Translin/Trax complex by endogenous RNA

Patricia M. Finkenstadt, Mihee Jeon, Jay M. Baraban

Research output: Contribution to journalArticle

Abstract

Translin and Trax are components of an RNA binding complex initially detected in extracts of brain and testes. Although other tissues appear to contain much lower or negligible levels of the Translin/Trax gel-shift complex, we found, unexpectedly, that several of these peripheral tissues express Translin and Trax proteins at levels comparable to those present in brain. In this study, we demonstrate that the paradoxically low levels of the Translin/Trax complex in kidney and other peripheral tissues are due to masking of these sites by endogenous RNA. Thus, these findings indicate that the Translin/Trax complex is involved in RNA processing in a broader range of tissues than previously recognized.

Original languageEnglish (US)
Pages (from-to)6-10
Number of pages5
JournalFEBS Letters
Volume498
Issue number1
DOIs
StatePublished - Jun 1 2001

Keywords

  • Cerebellum
  • Dendritic RNA
  • RNA binding protein
  • RNA localization

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Fingerprint Dive into the research topics of 'Masking of the Translin/Trax complex by endogenous RNA'. Together they form a unique fingerprint.

  • Cite this