Mas-related G protein-coupled receptors offer potential new targets for pain therapy

Vineeta Tiwari, Vinod Tiwari, Shaoqiu He, Tong Zhang, Srinivasa N. Raja, Xinzhong Dong, Yun Guan

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Scopus citations


The founding member of the Mas-related G-protein-coupled receptor (Mrgpr) family was discovered in 1986. Since then, many more members of this receptor family have been identifi ed in multiple species, and their physiologic functions have been investigated widely. Because they are expressed exclusively in small-diameter primary sensory neurons, the roles of Mrgpr proteins in pain and itch have been best studied. This review will focus specifi cally on the current knowledge of their roles in pathological pain and the potential development of new pharmacotherapies targeted at some Mrgprs for the treatment of chronic pain. We will also discuss the limitations and future scope of this receptor family in pain treatment.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Number of pages818
StatePublished - May 1 2016

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019


  • Dorsal root ganglion
  • Mas-related G-protein-coupled receptors
  • Mrgpr
  • Nerve injury
  • Pain

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


Dive into the research topics of 'Mas-related G protein-coupled receptors offer potential new targets for pain therapy'. Together they form a unique fingerprint.

Cite this