Mas-related G protein-coupled receptors offer potential new targets for pain therapy

Vineeta Tiwari, Vinod Tiwari, Shao-Qiu He, Tong Zhang, Srinivasa Naga Raja, Xinzhong Dong, Yun Guan

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The founding member of the Mas-related G-protein-coupled receptor (Mrgpr) family was discovered in 1986. Since then, many more members of this receptor family have been identifi ed in multiple species, and their physiologic functions have been investigated widely. Because they are expressed exclusively in small-diameter primary sensory neurons, the roles of Mrgpr proteins in pain and itch have been best studied. This review will focus specifi cally on the current knowledge of their roles in pathological pain and the potential development of new pharmacotherapies targeted at some Mrgprs for the treatment of chronic pain. We will also discuss the limitations and future scope of this receptor family in pain treatment.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages87-904
Number of pages818
Volume904
DOIs
StatePublished - May 1 2016

Publication series

NameAdvances in Experimental Medicine and Biology
Volume904
ISSN (Print)00652598
ISSN (Electronic)22148019

Keywords

  • Dorsal root ganglion
  • Mas-related G-protein-coupled receptors
  • Mrgpr
  • Nerve injury
  • Pain

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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  • Cite this

    Tiwari, V., Tiwari, V., He, S-Q., Zhang, T., Raja, S. N., Dong, X., & Guan, Y. (2016). Mas-related G protein-coupled receptors offer potential new targets for pain therapy. In Advances in Experimental Medicine and Biology (Vol. 904, pp. 87-904). (Advances in Experimental Medicine and Biology; Vol. 904). Springer New York LLC. https://doi.org/10.1007/978-94-017-7537-3_7