Markers of low-grade inflammation and soluble cell adhesion molecules in Chinese patients with coronary artery disease

Lu Fang, Heming Wei, Koon Hou Mak, Zhuowei Xiong, Jie Song, Dong Wang, Yean Leng Lim, Subroto B Chatterjee

Research output: Contribution to journalArticle

Abstract

Background: Inflammation plays an important role in atherosclerosis. Markers of low-grade chronic inflammation, such as C-reactive protein (CRP) and soluble cell adhesion molecules (sCAMs), have been associated with coronary artery disease (CAD). Objective: To evaluate the significance of inflammatory markers as novel risk factors for CAD in the Chinese population. Methods: High-sensitivity CRP (hs-CRP); sCAMs, including vascular cell adhesion molecule-1 (sVCAM-1), intercellular cell adhesion molecule-1 (sICAM-1), P-selectin (sP-selectin) and E-selectin (sE-selectin); and white blood cell (WBC) count were measured in 170 angiographically defined CAD patients (70% or greater stenosis affecting at least one vessel) and 177 healthy control subjects in the Chinese population in Singapore. Results: The levels of Hs-CRP, sVCAM-1 and sP-selectin, and the WBC count were higher in CAD patients than in control subjects (P

Original languageEnglish (US)
Pages (from-to)1433-1438
Number of pages6
JournalCanadian Journal of Cardiology
Volume20
Issue number14
StatePublished - Dec 2004

Fingerprint

Cell Adhesion Molecules
Coronary Artery Disease
C-Reactive Protein
Inflammation
P-Selectin
Vascular Cell Adhesion Molecule-1
Leukocyte Count
E-Selectin
Singapore
Intercellular Adhesion Molecule-1
Population
Atherosclerosis
Healthy Volunteers
Pathologic Constriction

Keywords

  • C-reactive protein
  • Cell adhesion molecules
  • Coronary artery disease
  • Inflammation
  • White blood cell count

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Markers of low-grade inflammation and soluble cell adhesion molecules in Chinese patients with coronary artery disease. / Fang, Lu; Wei, Heming; Mak, Koon Hou; Xiong, Zhuowei; Song, Jie; Wang, Dong; Lim, Yean Leng; Chatterjee, Subroto B.

In: Canadian Journal of Cardiology, Vol. 20, No. 14, 12.2004, p. 1433-1438.

Research output: Contribution to journalArticle

Fang, Lu ; Wei, Heming ; Mak, Koon Hou ; Xiong, Zhuowei ; Song, Jie ; Wang, Dong ; Lim, Yean Leng ; Chatterjee, Subroto B. / Markers of low-grade inflammation and soluble cell adhesion molecules in Chinese patients with coronary artery disease. In: Canadian Journal of Cardiology. 2004 ; Vol. 20, No. 14. pp. 1433-1438.
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AU - Mak, Koon Hou

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AU - Song, Jie

AU - Wang, Dong

AU - Lim, Yean Leng

AU - Chatterjee, Subroto B

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