@article{9918a8ed06864c958bd5f68e1ada79e6,
title = "Markers of B-vitamin deficiency and frailty in older women",
abstract = "Objective: To evaluate the association between markers of vitamins B12, B6 and folate deficiency and the geriatric syndrome of frailty. Design: Cross-sectional study of baseline measures from the combined Women's Health and Aging Studies. Setting: Baltimore, Maryland. Participants: Seven hundred three community-dwelling women, aged 70-79. Measurements: Frailty was defined by five-component screening criteria that include weight, grip strength, endurance, physical activity and walking speed measurements and modeled as binary and 3-level polytomous outcomes. Independent variables serum vitamin B6, vitamin B12, methylmalonic acid, total homocysteine, cystathionine and folate were modeled continuously and as abnormal versus normal. Results: Serum biomarker levels varied significantly by race. All analyses were race-stratified and results are reported only for Caucasian women due to small African American sample size. In polytomous logistic regression models of 3-level frailty, Caucasian women with increasing MMA, defined either continuously or using a predefined threshold, had 40-60% greater odds of being prefrail (p-values < 0.07) and 1.66-2.33 times greater odds of being frail (p-values < 0.02) compared to nonfrails after adjustment for age, education, low serum carotenoids, alcohol intake, cardiovascular disease and renal impairment. Both binary and polytomous frailty models evaluating vitamin B12 as the main exposure estimated odds ratios that were similar in trend yet slightly less significant than the MMA results. Conclusions: These results suggest that vitamin B12 deficiency may contribute to the frailty syndrome in community-dwelling older women. Future studies are needed to explore these relationships longitudinally. The Journal of Nutrition, Health & Aging",
keywords = "B12 and folate, Frailty syndrome, Older women, Vitamins B6",
author = "Matteini, {Amy M.} and Walston, {Jeremy D.} and Fallin, {M. D.} and K. Bandeen-Roche and Kao, {W. H.L.} and Semba, {R. D.} and Allen, {R. H.} and J. Guralnik and Fried, {L. P.} and Stabler, {S. P.}",
note = "Funding Information: 1. Johns Hopkins Institutions, Baltimore, MD; 2. University of Colorado Health Sciences Center, Denver, CO; 3. National Institute on Aging, Bethesda, MD. Corresponding author: Amy M. Matteini, PhD, Johns Hopkins University, 2024 East Monument Street, Suite 2-700, Baltimore, MD 21205. Phone: 410-905-2631, Fax number: 410-614-9625, Email: amatteini@jhmi.edu. Alternate corresponding author: Jeremy D. Walston, MD, John R. Burton Pavilion, 5505 Hopkins Bayview Circle, Baltimore, MD 21224. Phone: 410-550-1003, Fax: 410-550-2513, Email: jwalston@jhmi.edu. Funding sources: Supported by NIH/NIA, Claude D. Pepper Older American Independence Centers, Grant P30 AG021334, grants AG09834, R01 AG11703, R01 AG 027012 and T32 AG000247 and by contract N01 AG12112. Quest Diagnostics provided funding for phlebotomy and general laboratory analysis. Funding Information: Acknowlegdments: We thank Qian-Li Xue for help with preliminary longitudinal analyses. Author Contributions: All authors contributed to data analysis, interpretation of results, and manuscript preparation. Drs. Fried, Guralnik, and Walston participated in acquisition of study participants and data collection. Drs. Stabler and Allen carried out biomarker assays for the WHAS women. Financial Disclosures: Drs. Stabler and Allen hold patents involving the assays for homocysteine and methylmalonic acid and other metabolites in the diagnosis of vitamin B12 and folate deficiency. A company has been formed at the University of Colorado to perform the assays. Drs. Matteini, Fried, Walston, Fallin, Kao, and Bandeen-Roche have no financial support to disclose. Supported by NIH/NIA, Claude D. Pepper Older American Independence Centers, Grant P30 AG021334, grants AG09834, R01 AG11703, R01 AG 027012 and T32-AG000247 and by contract N01 AG12112. Quest Diagnostics provided funding for phlebotomy and general laboratory analysis. This work was supported in part by the Intramural Research Program, National Institute on Aging, NIH.",
year = "2008",
month = may,
doi = "10.1007/BF02982659",
language = "English (US)",
volume = "12",
pages = "303--308",
journal = "Journal of Nutrition, Health and Aging",
issn = "1279-7707",
publisher = "Springer Paris",
number = "5",
}