Markers of atherosclerosis and inflammation for prediction of coronary heart disease in older adults

Nicolas Rodondi, Pedro Marques-Vidal, Javed Butler, Kim Sutton-Tyrrell, Jacques Cornuz, Suzanne Satterfield, Tamara Harris, Douglas C. Bauer, Luigi Ferrucci, Eric Vittinghoff, Anne B. Newman

Research output: Contribution to journalArticlepeer-review

Abstract

Although both inflammatory and atherosclerosis markers have been associated with coronary heart disease (CHD) risk, data directly comparing their predictive value are limited. The authors compared the value of 2 atherosclerosis markers (ankle-arm index (AAI) and aortic pulse wave velocity (aPWV)) and 3 inflammatory markers (C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α)) in predicting CHD events. Among 2,191 adults aged 70-79 years at baseline (1997-1998) from the Health, Aging, and Body Composition Study cohort, the authors examined adjudicated incident myocardial infarction or CHD death ("hard" events) and "hard" events plus hospitalization for angina or coronary revascularization (total CHD events). During 8 years of follow-up between 1997-1998 and June 2007, 351 participants developed total CHD events (197 "hard" events). IL-6 (highest quartile vs. lowest: hazard ratio = 1.82, 95% confidence interval: 1.33, 2.49; P-trend <0.001) and AAI (AAI ≤ 0.9 vs. AAI 1.01-1.30: hazard ratio = 1.57, 95% confidence interval: 1.14, 2.18) predicted CHD events above traditional risk factors and modestly improved global measures of predictive accuracy. CRP, TNF-α, and aPWV had weaker associations. IL-6 and AAI accurately reclassified 6.6% and 3.3% of participants, respectively (P's ≤ 0.05). Results were similar for "hard" CHD, with higher reclassification rates for AAI. IL-6 and AAI are associated with future CHD events beyond traditional risk factors and modestly improve risk prediction in older adults.

Original languageEnglish (US)
Pages (from-to)540-549
Number of pages10
JournalAmerican Journal of Epidemiology
Volume171
Issue number5
DOIs
StatePublished - Mar 2010
Externally publishedYes

Keywords

  • Atherosclerosis
  • Cohort studies
  • Coronary disease
  • Inflammation

ASJC Scopus subject areas

  • Epidemiology

Fingerprint Dive into the research topics of 'Markers of atherosclerosis and inflammation for prediction of coronary heart disease in older adults'. Together they form a unique fingerprint.

Cite this