Markedly elevated GAD antibodies in SPS: Effects of age and illness duration

B. B. Murinson, M. Butler, K. Marfurt, S. Gleason, P. De Camilli, M. Solimena

Research output: Contribution to journalArticle

Abstract

Five hundred seventy-six patients with suspected stiff-person syndrome (SPS) underwent immunocytochemistry (ICC). Of these, 286 underwent radioimmunoassay (RIA) for glutamic acid decarboxylase (GAD) antibodies; 116 were GAD antibody positive by one or both tests. Ninety-six percent of those positive by ICC had RIA values several standard deviations above normal. RIA did not correlate with age or illness duration. Marked elevations of RIA for GAD antibodies were characteristic of ICC-confirmed SPS, and modest elevations were not.

Original languageEnglish (US)
Pages (from-to)2146-2148
Number of pages3
JournalNeurology
Volume63
Issue number11
DOIs
StatePublished - Dec 14 2004

ASJC Scopus subject areas

  • Clinical Neurology

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    Murinson, B. B., Butler, M., Marfurt, K., Gleason, S., De Camilli, P., & Solimena, M. (2004). Markedly elevated GAD antibodies in SPS: Effects of age and illness duration. Neurology, 63(11), 2146-2148. https://doi.org/10.1212/01.WNL.0000145661.01675.A8