Markedly elevated GAD antibodies in SPS: Effects of age and illness duration

B. B. Murinson; M. Butler; K. Marfurt; S. Gleason; P. De Camilli; M. Solimena

doi:10.1212/01.WNL.0000145661.01675.A8

Markedly elevated GAD antibodies in SPS: Effects of age and illness duration

B. B. Murinson, M. Butler, K. Marfurt, S. Gleason, P. De Camilli, M. Solimena

School of Medicine

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Five hundred seventy-six patients with suspected stiff-person syndrome (SPS) underwent immunocytochemistry (ICC). Of these, 286 underwent radioimmunoassay (RIA) for glutamic acid decarboxylase (GAD) antibodies; 116 were GAD antibody positive by one or both tests. Ninety-six percent of those positive by ICC had RIA values several standard deviations above normal. RIA did not correlate with age or illness duration. Marked elevations of RIA for GAD antibodies were characteristic of ICC-confirmed SPS, and modest elevations were not.

Original language	English (US)
Pages (from-to)	2146-2148
Number of pages	3
Journal	Neurology
Volume	63
Issue number	11
DOIs	https://doi.org/10.1212/01.WNL.0000145661.01675.A8
State	Published - Dec 14 2004

ASJC Scopus subject areas

Clinical Neurology

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abstract = "Five hundred seventy-six patients with suspected stiff-person syndrome (SPS) underwent immunocytochemistry (ICC). Of these, 286 underwent radioimmunoassay (RIA) for glutamic acid decarboxylase (GAD) antibodies; 116 were GAD antibody positive by one or both tests. Ninety-six percent of those positive by ICC had RIA values several standard deviations above normal. RIA did not correlate with age or illness duration. Marked elevations of RIA for GAD antibodies were characteristic of ICC-confirmed SPS, and modest elevations were not.",

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AU - Murinson, B. B.

AU - Butler, M.

AU - Marfurt, K.

AU - Gleason, S.

AU - De Camilli, P.

AU - Solimena, M.

PY - 2004/12/14

Y1 - 2004/12/14

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AB - Five hundred seventy-six patients with suspected stiff-person syndrome (SPS) underwent immunocytochemistry (ICC). Of these, 286 underwent radioimmunoassay (RIA) for glutamic acid decarboxylase (GAD) antibodies; 116 were GAD antibody positive by one or both tests. Ninety-six percent of those positive by ICC had RIA values several standard deviations above normal. RIA did not correlate with age or illness duration. Marked elevations of RIA for GAD antibodies were characteristic of ICC-confirmed SPS, and modest elevations were not.

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Markedly elevated GAD antibodies in SPS: Effects of age and illness duration

Abstract

ASJC Scopus subject areas

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