Marked behavioral and biochemical sensitivity to lesion size in the posterior cortex of the rat

Timothy H. Moran, Kenneth L. Kubos, Paul R. Sanberg, Robert G. Robinson

Research output: Contribution to journalArticlepeer-review

Abstract

Unilateral focal cortical suction lesions of varying diameter from 0.7 to 2.0 mm were made in the right posterior lateral cortex of rats. Only the 1.0 mm lesion size resulted in spontaneous postoperative hyperactivity. This increased activity was accompanied by significantly elevations in substantia nigra and caudate nucleus dopamine concentrations. Other lesion sizes did not effect behavior or brain biochemical concentrations in this fashion. These results suggest a functional organization in this area of posterior cortex which affects both neurochemistry and behavior.

Original languageEnglish (US)
Pages (from-to)1337-1342
Number of pages6
JournalLife Sciences
Volume35
Issue number13
DOIs
StatePublished - Sep 24 1984

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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