Marked behavioral and biochemical sensitivity to lesion size in the posterior cortex of the rat

Timothy H. Moran; Kenneth L. Kubos; Paul R. Sanberg; Robert G. Robinson

doi:10.1016/0024-3205(84)90389-8

Marked behavioral and biochemical sensitivity to lesion size in the posterior cortex of the rat

Timothy H. Moran, Kenneth L. Kubos, Paul R. Sanberg, Robert G. Robinson

School of Medicine

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Unilateral focal cortical suction lesions of varying diameter from 0.7 to 2.0 mm were made in the right posterior lateral cortex of rats. Only the 1.0 mm lesion size resulted in spontaneous postoperative hyperactivity. This increased activity was accompanied by significantly elevations in substantia nigra and caudate nucleus dopamine concentrations. Other lesion sizes did not effect behavior or brain biochemical concentrations in this fashion. These results suggest a functional organization in this area of posterior cortex which affects both neurochemistry and behavior.

Original language	English (US)
Pages (from-to)	1337-1342
Number of pages	6
Journal	Life Sciences
Volume	35
Issue number	13
DOIs	https://doi.org/10.1016/0024-3205(84)90389-8
State	Published - Sep 24 1984

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/0024-3205(84)90389-8

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title = "Marked behavioral and biochemical sensitivity to lesion size in the posterior cortex of the rat",

abstract = "Unilateral focal cortical suction lesions of varying diameter from 0.7 to 2.0 mm were made in the right posterior lateral cortex of rats. Only the 1.0 mm lesion size resulted in spontaneous postoperative hyperactivity. This increased activity was accompanied by significantly elevations in substantia nigra and caudate nucleus dopamine concentrations. Other lesion sizes did not effect behavior or brain biochemical concentrations in this fashion. These results suggest a functional organization in this area of posterior cortex which affects both neurochemistry and behavior.",

author = "Moran, {Timothy H.} and Kubos, {Kenneth L.} and Sanberg, {Paul R.} and Robinson, {Robert G.}",

note = "Funding Information: Thls work was supported in part by NIH grants, Research Sclentist Development Award (RGR) MH 00163, NS 15178, NS 18622, MH 15330 and Tourette Syndrome Association Research Fellowship (PRS). Kenneth Saad did the flgure preparation and Paula Bolduc did the typing.",

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AU - Moran, Timothy H.

AU - Kubos, Kenneth L.

AU - Sanberg, Paul R.

AU - Robinson, Robert G.

N1 - Funding Information: Thls work was supported in part by NIH grants, Research Sclentist Development Award (RGR) MH 00163, NS 15178, NS 18622, MH 15330 and Tourette Syndrome Association Research Fellowship (PRS). Kenneth Saad did the flgure preparation and Paula Bolduc did the typing.

PY - 1984/9/24

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N2 - Unilateral focal cortical suction lesions of varying diameter from 0.7 to 2.0 mm were made in the right posterior lateral cortex of rats. Only the 1.0 mm lesion size resulted in spontaneous postoperative hyperactivity. This increased activity was accompanied by significantly elevations in substantia nigra and caudate nucleus dopamine concentrations. Other lesion sizes did not effect behavior or brain biochemical concentrations in this fashion. These results suggest a functional organization in this area of posterior cortex which affects both neurochemistry and behavior.

AB - Unilateral focal cortical suction lesions of varying diameter from 0.7 to 2.0 mm were made in the right posterior lateral cortex of rats. Only the 1.0 mm lesion size resulted in spontaneous postoperative hyperactivity. This increased activity was accompanied by significantly elevations in substantia nigra and caudate nucleus dopamine concentrations. Other lesion sizes did not effect behavior or brain biochemical concentrations in this fashion. These results suggest a functional organization in this area of posterior cortex which affects both neurochemistry and behavior.

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Marked behavioral and biochemical sensitivity to lesion size in the posterior cortex of the rat

Abstract

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