Marchiafava-Bignami-like injury of the corpus callosum in an infant

Sandra P. Toelle, T. A G M Huisman, E. Martin, E. Boltshauser

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


We report on a 16-month-old boy who presented with truncal ataxia and intermittent nystagmus. Magnetic resonance imaging (MRI) at 19 months showed a T2-hyperintensity of the splenium and the genu of the corpus callosum with extension into the adjacent frontal white matter. Diffusion tensor imaging (DTI) revealed a corresponding area of restricted diffusion, suggesting cytotoxic oedema. The extent and localisation of the signal abnormalities mimic tissue injury as seen in Marchiafava-Bignami disease (MBD). Metabolic investigations were normal. Follow-up imaging at 24 months showed a similar T2-hyperintensity of the corpus callosum and white matter while on DTI the cytotoxic oedema had resolved. Clinically a remaining truncal and gait ataxia, clumsiness and a developmental delay is seen. Goal of this case report is (a) to present a rare case of Marchiafava-Bignami-like injury of the corpus callosum in an infant and (b) to discuss the neuroradiological imaging findings including MRI and DTI.

Original languageEnglish (US)
Pages (from-to)328-331
Number of pages4
Issue number5
StatePublished - Oct 2005
Externally publishedYes


  • Corpus callosum
  • Magnetic resonance imaging
  • Marchiafava-Bignami disease
  • Splenium

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology


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