Mapping the trajectory of the stria terminalis of the human limbic system using high spatial resolution diffusion tensor tractography

Arash Kamali, David Mark Yousem, Doris Lin, Haris Sair, Siva P. Jasti, Zafer Keser, Roy F. Riascos, Khader M. Hasan

Research output: Contribution to journalArticle

Abstract

The human limbic system is composed of gray and white matter structures which have been known to have a role in core processes such as motivation, memory, emotion, social behavior, self-awareness as well as certain primitive instincts. Multiple functional studies investigated some of these brain tasks in human brain limbic system. However, the underlying fine fiber pathways of the limbic system including the trajectory of the stria terminalis have not been delineated separately by prior diffusion weighted imaging. The ability to trace the underlying fiber anatomy noninvasively using diffusion tensor tractography (DTT) would be helpful to study the neurophysiology of these tracts in different functions in future functional studies. Few studies have focused on the stria terminalis using diffusion tensor tractography. Yet, the trajectory of the stria terminalis and some fine subtrajectories of the fornix have not been elucidated by prior DTT studies. We decided to further investigate these fine neuronal trajectory using tractography and high spatial resolution diffusion tensor imaging on 3T. Fifteen healthy right-handed men (age range 24-37 years) were studied. We delineated the detailed trajectories of the stria terminalis and fornix bilaterally in fifteen normal adult human brains. Using a high resolution DTT technique, we demonstrate for the first time, the trajectory of stria terminalis as well as detailed precommissural and postcommissural connectivity of the forniceal columns.

Original languageEnglish (US)
Pages (from-to)45-50
Number of pages6
JournalNeuroscience Letters
Volume608
DOIs
StatePublished - Nov 3 2015

Fingerprint

Limbic System
Diffusion Tensor Imaging
Brain
Instinct
Neurophysiology
Aptitude
Social Behavior
Motivation
Anatomy
Emotions

Keywords

  • Amygdala
  • Diffusion tensor imaging
  • Fornix
  • High resolution
  • Hippocampus
  • Hypothalamus
  • Limbic
  • Septal nuclei
  • Stria terminalis
  • Tractography

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Mapping the trajectory of the stria terminalis of the human limbic system using high spatial resolution diffusion tensor tractography. / Kamali, Arash; Yousem, David Mark; Lin, Doris; Sair, Haris; Jasti, Siva P.; Keser, Zafer; Riascos, Roy F.; Hasan, Khader M.

In: Neuroscience Letters, Vol. 608, 03.11.2015, p. 45-50.

Research output: Contribution to journalArticle

@article{f38502716b844e82982802550c7bc799,
title = "Mapping the trajectory of the stria terminalis of the human limbic system using high spatial resolution diffusion tensor tractography",
abstract = "The human limbic system is composed of gray and white matter structures which have been known to have a role in core processes such as motivation, memory, emotion, social behavior, self-awareness as well as certain primitive instincts. Multiple functional studies investigated some of these brain tasks in human brain limbic system. However, the underlying fine fiber pathways of the limbic system including the trajectory of the stria terminalis have not been delineated separately by prior diffusion weighted imaging. The ability to trace the underlying fiber anatomy noninvasively using diffusion tensor tractography (DTT) would be helpful to study the neurophysiology of these tracts in different functions in future functional studies. Few studies have focused on the stria terminalis using diffusion tensor tractography. Yet, the trajectory of the stria terminalis and some fine subtrajectories of the fornix have not been elucidated by prior DTT studies. We decided to further investigate these fine neuronal trajectory using tractography and high spatial resolution diffusion tensor imaging on 3T. Fifteen healthy right-handed men (age range 24-37 years) were studied. We delineated the detailed trajectories of the stria terminalis and fornix bilaterally in fifteen normal adult human brains. Using a high resolution DTT technique, we demonstrate for the first time, the trajectory of stria terminalis as well as detailed precommissural and postcommissural connectivity of the forniceal columns.",
keywords = "Amygdala, Diffusion tensor imaging, Fornix, High resolution, Hippocampus, Hypothalamus, Limbic, Septal nuclei, Stria terminalis, Tractography",
author = "Arash Kamali and Yousem, {David Mark} and Doris Lin and Haris Sair and Jasti, {Siva P.} and Zafer Keser and Riascos, {Roy F.} and Hasan, {Khader M.}",
year = "2015",
month = "11",
day = "3",
doi = "10.1016/j.neulet.2015.09.035",
language = "English (US)",
volume = "608",
pages = "45--50",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Mapping the trajectory of the stria terminalis of the human limbic system using high spatial resolution diffusion tensor tractography

AU - Kamali, Arash

AU - Yousem, David Mark

AU - Lin, Doris

AU - Sair, Haris

AU - Jasti, Siva P.

AU - Keser, Zafer

AU - Riascos, Roy F.

AU - Hasan, Khader M.

PY - 2015/11/3

Y1 - 2015/11/3

N2 - The human limbic system is composed of gray and white matter structures which have been known to have a role in core processes such as motivation, memory, emotion, social behavior, self-awareness as well as certain primitive instincts. Multiple functional studies investigated some of these brain tasks in human brain limbic system. However, the underlying fine fiber pathways of the limbic system including the trajectory of the stria terminalis have not been delineated separately by prior diffusion weighted imaging. The ability to trace the underlying fiber anatomy noninvasively using diffusion tensor tractography (DTT) would be helpful to study the neurophysiology of these tracts in different functions in future functional studies. Few studies have focused on the stria terminalis using diffusion tensor tractography. Yet, the trajectory of the stria terminalis and some fine subtrajectories of the fornix have not been elucidated by prior DTT studies. We decided to further investigate these fine neuronal trajectory using tractography and high spatial resolution diffusion tensor imaging on 3T. Fifteen healthy right-handed men (age range 24-37 years) were studied. We delineated the detailed trajectories of the stria terminalis and fornix bilaterally in fifteen normal adult human brains. Using a high resolution DTT technique, we demonstrate for the first time, the trajectory of stria terminalis as well as detailed precommissural and postcommissural connectivity of the forniceal columns.

AB - The human limbic system is composed of gray and white matter structures which have been known to have a role in core processes such as motivation, memory, emotion, social behavior, self-awareness as well as certain primitive instincts. Multiple functional studies investigated some of these brain tasks in human brain limbic system. However, the underlying fine fiber pathways of the limbic system including the trajectory of the stria terminalis have not been delineated separately by prior diffusion weighted imaging. The ability to trace the underlying fiber anatomy noninvasively using diffusion tensor tractography (DTT) would be helpful to study the neurophysiology of these tracts in different functions in future functional studies. Few studies have focused on the stria terminalis using diffusion tensor tractography. Yet, the trajectory of the stria terminalis and some fine subtrajectories of the fornix have not been elucidated by prior DTT studies. We decided to further investigate these fine neuronal trajectory using tractography and high spatial resolution diffusion tensor imaging on 3T. Fifteen healthy right-handed men (age range 24-37 years) were studied. We delineated the detailed trajectories of the stria terminalis and fornix bilaterally in fifteen normal adult human brains. Using a high resolution DTT technique, we demonstrate for the first time, the trajectory of stria terminalis as well as detailed precommissural and postcommissural connectivity of the forniceal columns.

KW - Amygdala

KW - Diffusion tensor imaging

KW - Fornix

KW - High resolution

KW - Hippocampus

KW - Hypothalamus

KW - Limbic

KW - Septal nuclei

KW - Stria terminalis

KW - Tractography

UR - http://www.scopus.com/inward/record.url?scp=84944199400&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84944199400&partnerID=8YFLogxK

U2 - 10.1016/j.neulet.2015.09.035

DO - 10.1016/j.neulet.2015.09.035

M3 - Article

C2 - 26434353

AN - SCOPUS:84944199400

VL - 608

SP - 45

EP - 50

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

ER -