Mapping the road to resilience: Novel math for the study of frailty

Luigi Ferrucci, Francesco Giallauria, David Schlessinger

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Frailty stands at the nexus of geriatrics and gerontology, and requires both basic biology and clinical knowledge for its analysis. Understanding frailty difficulties much more than simply adding another outcome measure in epidemiological studies. The major challenge is the identification of multiple feed-forward and feed-back signaling pathways involved in the maintenance of biological homeostasis in complex organisms that may fail with aging. The cause of frailty and loss of resilience is probably a progressive loss of redundancy in these response patterns and connections. Advances toward the development of a theoretical model that can potentially embrace the complexity of frailty should be highly encouraged, especially models designed to explain the biology of aging which can promote a better integration and communication between scientists who study this problem from different perspectives.

Original languageEnglish (US)
Pages (from-to)677-679
Number of pages3
JournalMechanisms of Ageing and Development
Issue number11
StatePublished - Nov 2008
Externally publishedYes


  • aging
  • biological homeostasis
  • biology of aging
  • frailty
  • resilience

ASJC Scopus subject areas

  • Aging
  • Developmental Biology


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