Mapping the medical outcomes study HIV health survey (MOS-HIV) to the EuroQoL 5 Dimension (EQ-5D-3 L) utility index

Yuan Shi; Jennifer Thompson; A. Sarah Walker; Nicholas I. Paton; Yin Bun Cheung; E. Agweng; P. Awio; G. Bakeinyaga; C. Isabirye; U. Kabuga; S. Kasuswa; M. Katuramu; C. Kityo; F. Kiweewa; H. Kyomugisha; E. Lutalo; P. Mugyenyi; D. Mulima; H. Musana; G. Musitwa; V. Musiime; M. Ndigendawan; H. Namata; J. Nkalubo; P. Ocitti Labejja; P. Okello; P. Olal; G. Pimundu; P. Segonga; F. Ssali; Z. Tamale; D. Tumukunde; W. Namala; R. Byaruhanga; J. Kayiwa; J. Tukamushaba; S. Abunyang; D. Eram; O. Denis; R. Lwalanda; L. Mugarura; J. Namusanje; I. Nankya; E. Ndashimye; E. Nabulime; D. Mulima; O. Senfuma; G. Bihabwa; E. Buluma; P. Easterbrook; A. Elbireer; A. Kambugu; D. Kamya; M. Katwere; R. Kiggundu; C. Komujuni; E. Laker; E. Lubwama; I. Mambule; J. Matovu; A. Nakajubi; J. Nakku; R. Nalumenya; L. Namuyimbwa; F. Semitala; B. Wandera; J. Wanyama; H. Mugerwa; A. Lugemwa; E. Ninsiima; T. Ssenkindu; S. Mwebe; L. Atwine; H. William; C. Katemba; S. Abunyang; M. Acaku; P. Ssebutinde; H. Kitizo; J. Kukundakwe; M. Naluguza; K. Ssegawa; F. Nsibuka; P. Tuhirirwe; M. Fortunate; J. Acen; J. Achidri; A. Amone; M. Chamai; J. Ditai; M. Kemigisa; M. Kiconco; C. Matama; D. Mbanza; F. Nambaziira; M. Owor Odoi; A. Rweyora; G. Tumwebaze; H. Kalanzi; J. Katabaazi; A. Kiyingi; M. Mbidde; M. Mugenyi; R. Mwebaze; P. Okong; I. Senoga; M. Abwola; D. Baliruno; J. Bwomezi; A. Kasede; M. Mudoola; R. Namisi; F. Ssennono; S. Tuhirwe; G. Abongomera; G. Amone; J. Abach; I. Aciro; B. Arach; P. Kidega; J. Omongin; E. Ocung; W. Odong; A. Philliam; H. Alima; B. Ahimbisibwe; E. Atuhaire; F. Atukunda; G. Bekusike; A. Bulegyeya; D. Kahatano; S. Kamukama; J. Kyoshabire; A. Nassali; A. Mbonye; T. M. Naturinda; A. Nshabohurira; H. Ntawiha; A. Rogers; M. Tibyasa; S. Kiirya; D. Atwongyeire; A. Nankya; C. Draleku; D. Nakiboneka; D. Odoch; L. Lakidi; R. Ruganda; R. Abiriga; M. Mulindwa; F. Balmoi; S. Kafuma; E. Moriku; J. Hakim; A. Reid; E. Chidziva; G. Musoro; C. Warambwa; G. Tinago; S. Mutsai; M. Phiri; S. Mudzingwa; T. Bafana; V. Masore; C. Moyo; R. Nhema; S. Chitongo; Robert Heyderman; Lucky Kabanga; Symon Kaunda; Aubrey Kudzala; Linly Lifa; Jane Mallewa; Mike Moore; Chrissie Mtali; George Musowa; Grace Mwimaniwa; Rosemary Sikwese; Joep Van Oosterhout; Milton Ziwoya; H. Chimbaka; B. Chitete; S. Kamanga; T. Kayinga E. Makwakwa; R. Mbiya; M. Mlenga; T. Mphande; C. Mtika; G. Mushani; O. Ndhlovu; M. Ngonga; I. Nkhana; R. Nyirenda; P. Cheruiyot; C. Kwobah; W. Lokitala Ekiru; M. Mokaya; A. Mudogo; A. Nzioka; A. Siika; M. Tanui; S. Wachira; K. Wools-Kaloustian; P. Alipalli; E. Chikatula; J. Kipaila; I. Kunda; S. Lakhi; J. Malama; W. Mufwambi; L. Mulenga; P. Mwaba; E. Mwamba; A. Mweemba; M. Namfukwe; E. Kerukadho; B. Ngwatu; J. Birungi; N. Paton; J. Boles; A. Burke; L. Castle; S. Ghuman; L. Kendall; A. Hoppe; S. Tebbs; M. Thomason; J. Thompson; S. Walker; J. Whittle; H. Wilkes; N. Young; C. Kapuya; F. Kyomuhendo; D. Kyakundi; N. Mkandawire; S. Mulambo; S. Senyonjo; B. Angus; A. Arenas-Pinto; A. Palfreeman; F. Post; D. Ishola; J. Arribas; R. Colebunders; M. Floridia; M. Giuliano; P. Mallon; P. Walsh; M. De Rosa; E. Rinaldi; I. Weller; C. Gilks; J. Hakim; A. Kangewende; S. Lakhi; E. Luyirika; F. Miiro; P. Mwamba; P. Mugyenyi; S. Ojoo; N. Paton; S. Phiri; J. Van Oosterhout; A. Siika; S. Walker; A. Wapakabulo; T. Peto; N. French; J. Matenga; G. Cloherty; J. Van Wyk; M. Norton; S. Lehrman; P. Lamba; K. Malik; J. Rooney; W. Snowden; J. Villacian

doi:10.1186/s12955-019-1135-8

Mapping the medical outcomes study HIV health survey (MOS-HIV) to the EuroQoL 5 Dimension (EQ-5D-3 L) utility index

Yuan Shi, Jennifer Thompson, A. Sarah Walker, Nicholas I. Paton, Yin Bun Cheung, E. Agweng, P. Awio, G. Bakeinyaga, C. Isabirye, U. Kabuga, S. Kasuswa, M. Katuramu, C. Kityo, F. Kiweewa, H. Kyomugisha, E. Lutalo, P. Mugyenyi, D. Mulima, H. Musana, G. MusitwaV. Musiime, M. Ndigendawan, H. Namata, J. Nkalubo, P. Ocitti Labejja, P. Okello, P. Olal, G. Pimundu, P. Segonga, F. Ssali, Z. Tamale, D. Tumukunde, W. Namala, R. Byaruhanga, J. Kayiwa, J. Tukamushaba, S. Abunyang, D. Eram, O. Denis, R. Lwalanda, L. Mugarura, J. Namusanje, I. Nankya, E. Ndashimye, E. Nabulime, D. Mulima, O. Senfuma, G. Bihabwa, E. Buluma, P. Easterbrook, A. Elbireer, A. Kambugu, D. Kamya, M. Katwere, R. Kiggundu, C. Komujuni, E. Laker, E. Lubwama, I. Mambule, J. Matovu, A. Nakajubi, J. Nakku, R. Nalumenya, L. Namuyimbwa, F. Semitala, B. Wandera, J. Wanyama, H. Mugerwa, A. Lugemwa, E. Ninsiima, T. Ssenkindu, S. Mwebe, L. Atwine, H. William, C. Katemba, S. Abunyang, M. Acaku, P. Ssebutinde, H. Kitizo, J. Kukundakwe, M. Naluguza, K. Ssegawa, F. Nsibuka, P. Tuhirirwe, M. Fortunate, J. Acen, J. Achidri, A. Amone, M. Chamai, J. Ditai, M. Kemigisa, M. Kiconco, C. Matama, D. Mbanza, F. Nambaziira, M. Owor Odoi, A. Rweyora, G. Tumwebaze, H. Kalanzi, J. Katabaazi, A. Kiyingi, M. Mbidde, M. Mugenyi, R. Mwebaze, P. Okong, I. Senoga, M. Abwola, D. Baliruno, J. Bwomezi, A. Kasede, M. Mudoola, R. Namisi, F. Ssennono, S. Tuhirwe, G. Abongomera, G. Amone, J. Abach, I. Aciro, B. Arach, P. Kidega, J. Omongin, E. Ocung, W. Odong, A. Philliam, H. Alima, B. Ahimbisibwe, E. Atuhaire, F. Atukunda, G. Bekusike, A. Bulegyeya, D. Kahatano, S. Kamukama, J. Kyoshabire, A. Nassali, A. Mbonye, T. M. Naturinda, A. Nshabohurira, H. Ntawiha, A. Rogers, M. Tibyasa, S. Kiirya, D. Atwongyeire, A. Nankya, C. Draleku, D. Nakiboneka, D. Odoch, L. Lakidi, R. Ruganda, R. Abiriga, M. Mulindwa, F. Balmoi, S. Kafuma, E. Moriku, J. Hakim, A. Reid, E. Chidziva, G. Musoro, C. Warambwa, G. Tinago, S. Mutsai, M. Phiri, S. Mudzingwa, T. Bafana, V. Masore, C. Moyo, R. Nhema, S. Chitongo, Robert Heyderman, Lucky Kabanga, Symon Kaunda, Aubrey Kudzala, Linly Lifa, Jane Mallewa, Mike Moore, Chrissie Mtali, George Musowa, Grace Mwimaniwa, Rosemary Sikwese, Joep Van Oosterhout, Milton Ziwoya, H. Chimbaka, B. Chitete, S. Kamanga, T. Kayinga E. Makwakwa, R. Mbiya, M. Mlenga, T. Mphande, C. Mtika, G. Mushani, O. Ndhlovu, M. Ngonga, I. Nkhana, R. Nyirenda, P. Cheruiyot, C. Kwobah, W. Lokitala Ekiru, M. Mokaya, A. Mudogo, A. Nzioka, A. Siika, M. Tanui, S. Wachira, K. Wools-Kaloustian, P. Alipalli, E. Chikatula, J. Kipaila, I. Kunda, S. Lakhi, J. Malama, W. Mufwambi, L. Mulenga, P. Mwaba, E. Mwamba, A. Mweemba, M. Namfukwe, E. Kerukadho, B. Ngwatu, J. Birungi, N. Paton, J. Boles, A. Burke, L. Castle, S. Ghuman, L. Kendall, A. Hoppe, S. Tebbs, M. Thomason, J. Thompson, S. Walker, J. Whittle, H. Wilkes, N. Young, C. Kapuya, F. Kyomuhendo, D. Kyakundi, N. Mkandawire, S. Mulambo, S. Senyonjo, B. Angus, A. Arenas-Pinto, A. Palfreeman, F. Post, D. Ishola, J. Arribas, R. Colebunders, M. Floridia, M. Giuliano, P. Mallon, P. Walsh, M. De Rosa, E. Rinaldi, I. Weller, C. Gilks, J. Hakim, A. Kangewende, S. Lakhi, E. Luyirika, F. Miiro, P. Mwamba, P. Mugyenyi, S. Ojoo, N. Paton, S. Phiri, J. Van Oosterhout, A. Siika, S. Walker, A. Wapakabulo, T. Peto, N. French, J. Matenga, G. Cloherty, J. Van Wyk, M. Norton, S. Lehrman, P. Lamba, K. Malik, J. Rooney, W. Snowden, J. Villacian

School of Medicine

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Background: Mapping of health-related quality-of-life measures to health utility values can facilitate cost-utility evaluation. Regression-based methods tend to lead to shrinkage of variance. This study aims to map the Medical Outcomes Study HIV Health Survey (MOS-HIV) to EuroQoL 5 Dimensions (EQ-5D-3 L) utility index, and to characterize the performance of three mapping methods, including ordinary least squares (OLS), equi-percentile method (EPM), and a recently proposed method called Mean Rank Method (MRM). Methods: This is a secondary analysis of data from a randomized HIV treatment trial. Baseline data from 421 participants were used to develop mapping functions. Follow-up data from 236 participants was used to validate the mapping functions. Results: In the training dataset, MRM and OLS, but not EPM, reproduced the observed mean utility (0.731). MRM, OLS and EPM under-estimated the standard deviation by 0.3, 26.6 and 1.7%, respectively. MRM had the lowest mean absolute error (0.143) and highest intraclass correlation coefficient (0.723) with the observed utility values, whereas OLS had the lowest mean squared error (0.038) and highest R-squared (0.542). Regressing the MRM- and OLS-mapped utility values upon body mass index and log-viral load gave covariate associations comparable to those estimated from the observed utility data (all P > 0.10). EPM did not achieve this property. Findings from the validation data were similar. Conclusions: Functions are available for mapping the MOS-HIV to the EQ-5D-3 L utility values. MRM and OLS were comparable in terms of agreement with the observed utility values at the individual level. MRM had better performance at the group level in terms of describing the utility distribution. Trial registration: NCT00988039. Registered 30 September 2009.

Original language	English (US)
Article number	83
Journal	Health and Quality of Life Outcomes
Volume	17
Issue number	1
DOIs	https://doi.org/10.1186/s12955-019-1135-8
State	Published - May 10 2019

Keywords

EQ-5D
Health utility
Mapping
Medical outcomes study HIV health survey

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health

Access to Document

10.1186/s12955-019-1135-8

Cite this

Shi, Y., Thompson, J., Walker, A. S., Paton, N. I., Cheung, Y. B., Agweng, E., Awio, P., Bakeinyaga, G., Isabirye, C., Kabuga, U., Kasuswa, S., Katuramu, M., Kityo, C., Kiweewa, F., Kyomugisha, H., Lutalo, E., Mugyenyi, P., Mulima, D., Musana, H., ... Villacian, J. (2019). Mapping the medical outcomes study HIV health survey (MOS-HIV) to the EuroQoL 5 Dimension (EQ-5D-3 L) utility index. Health and Quality of Life Outcomes, 17(1), Article 83. https://doi.org/10.1186/s12955-019-1135-8

Shi, Y, Thompson, J, Walker, AS, Paton, NI, Cheung, YB, Agweng, E, Awio, P, Bakeinyaga, G, Isabirye, C, Kabuga, U, Kasuswa, S, Katuramu, M, Kityo, C, Kiweewa, F, Kyomugisha, H, Lutalo, E, Mugyenyi, P, Mulima, D, Musana, H, Musitwa, G, Musiime, V, Ndigendawan, M, Namata, H, Nkalubo, J, Labejja, PO, Okello, P, Olal, P, Pimundu, G, Segonga, P, Ssali, F, Tamale, Z, Tumukunde, D, Namala, W, Byaruhanga, R, Kayiwa, J, Tukamushaba, J, Abunyang, S, Eram, D, Denis, O, Lwalanda, R, Mugarura, L, Namusanje, J, Nankya, I, Ndashimye, E, Nabulime, E, Mulima, D, Senfuma, O, Bihabwa, G, Buluma, E, Easterbrook, P, Elbireer, A, Kambugu, A, Kamya, D, Katwere, M, Kiggundu, R, Komujuni, C, Laker, E, Lubwama, E, Mambule, I, Matovu, J, Nakajubi, A, Nakku, J, Nalumenya, R, Namuyimbwa, L, Semitala, F, Wandera, B, Wanyama, J, Mugerwa, H, Lugemwa, A, Ninsiima, E, Ssenkindu, T, Mwebe, S, Atwine, L, William, H, Katemba, C, Abunyang, S, Acaku, M, Ssebutinde, P, Kitizo, H, Kukundakwe, J, Naluguza, M, Ssegawa, K, Nsibuka, F, Tuhirirwe, P, Fortunate, M, Acen, J, Achidri, J, Amone, A, Chamai, M, Ditai, J, Kemigisa, M, Kiconco, M, Matama, C, Mbanza, D, Nambaziira, F, Odoi, MO, Rweyora, A, Tumwebaze, G, Kalanzi, H, Katabaazi, J, Kiyingi, A, Mbidde, M, Mugenyi, M, Mwebaze, R, Okong, P, Senoga, I, Abwola, M, Baliruno, D, Bwomezi, J, Kasede, A, Mudoola, M, Namisi, R, Ssennono, F, Tuhirwe, S, Abongomera, G, Amone, G, Abach, J, Aciro, I, Arach, B, Kidega, P, Omongin, J, Ocung, E, Odong, W, Philliam, A, Alima, H, Ahimbisibwe, B, Atuhaire, E, Atukunda, F, Bekusike, G, Bulegyeya, A, Kahatano, D, Kamukama, S, Kyoshabire, J, Nassali, A, Mbonye, A, Naturinda, TM, Nshabohurira, A, Ntawiha, H, Rogers, A, Tibyasa, M, Kiirya, S, Atwongyeire, D, Nankya, A, Draleku, C, Nakiboneka, D, Odoch, D, Lakidi, L, Ruganda, R, Abiriga, R, Mulindwa, M, Balmoi, F, Kafuma, S, Moriku, E, Hakim, J, Reid, A, Chidziva, E, Musoro, G, Warambwa, C, Tinago, G, Mutsai, S, Phiri, M, Mudzingwa, S, Bafana, T, Masore, V, Moyo, C, Nhema, R, Chitongo, S, Heyderman, R, Kabanga, L, Kaunda, S, Kudzala, A, Lifa, L, Mallewa, J, Moore, M, Mtali, C, Musowa, G, Mwimaniwa, G, Sikwese, R, Van Oosterhout, J, Ziwoya, M, Chimbaka, H, Chitete, B, Kamanga, S, Makwakwa, TKE, Mbiya, R, Mlenga, M, Mphande, T, Mtika, C, Mushani, G, Ndhlovu, O, Ngonga, M, Nkhana, I, Nyirenda, R, Cheruiyot, P, Kwobah, C, Ekiru, WL, Mokaya, M, Mudogo, A, Nzioka, A, Siika, A, Tanui, M, Wachira, S, Wools-Kaloustian, K, Alipalli, P, Chikatula, E, Kipaila, J, Kunda, I, Lakhi, S, Malama, J, Mufwambi, W, Mulenga, L, Mwaba, P, Mwamba, E, Mweemba, A, Namfukwe, M, Kerukadho, E, Ngwatu, B, Birungi, J, Paton, N, Boles, J, Burke, A, Castle, L, Ghuman, S, Kendall, L, Hoppe, A, Tebbs, S, Thomason, M, Thompson, J, Walker, S, Whittle, J, Wilkes, H, Young, N, Kapuya, C, Kyomuhendo, F, Kyakundi, D, Mkandawire, N, Mulambo, S, Senyonjo, S, Angus, B, Arenas-Pinto, A, Palfreeman, A, Post, F, Ishola, D, Arribas, J, Colebunders, R, Floridia, M, Giuliano, M, Mallon, P, Walsh, P, De Rosa, M, Rinaldi, E, Weller, I, Gilks, C, Hakim, J, Kangewende, A, Lakhi, S, Luyirika, E, Miiro, F, Mwamba, P, Mugyenyi, P, Ojoo, S, Paton, N, Phiri, S, Van Oosterhout, J, Siika, A, Walker, S, Wapakabulo, A, Peto, T, French, N, Matenga, J, Cloherty, G, Van Wyk, J, Norton, M, Lehrman, S, Lamba, P, Malik, K, Rooney, J, Snowden, W & Villacian, J 2019, 'Mapping the medical outcomes study HIV health survey (MOS-HIV) to the EuroQoL 5 Dimension (EQ-5D-3 L) utility index', Health and Quality of Life Outcomes, vol. 17, no. 1, 83. https://doi.org/10.1186/s12955-019-1135-8

@article{ea6b33a3e6a24518a99ea420f69ec05f,

title = "Mapping the medical outcomes study HIV health survey (MOS-HIV) to the EuroQoL 5 Dimension (EQ-5D-3 L) utility index",

abstract = "Background: Mapping of health-related quality-of-life measures to health utility values can facilitate cost-utility evaluation. Regression-based methods tend to lead to shrinkage of variance. This study aims to map the Medical Outcomes Study HIV Health Survey (MOS-HIV) to EuroQoL 5 Dimensions (EQ-5D-3 L) utility index, and to characterize the performance of three mapping methods, including ordinary least squares (OLS), equi-percentile method (EPM), and a recently proposed method called Mean Rank Method (MRM). Methods: This is a secondary analysis of data from a randomized HIV treatment trial. Baseline data from 421 participants were used to develop mapping functions. Follow-up data from 236 participants was used to validate the mapping functions. Results: In the training dataset, MRM and OLS, but not EPM, reproduced the observed mean utility (0.731). MRM, OLS and EPM under-estimated the standard deviation by 0.3, 26.6 and 1.7%, respectively. MRM had the lowest mean absolute error (0.143) and highest intraclass correlation coefficient (0.723) with the observed utility values, whereas OLS had the lowest mean squared error (0.038) and highest R-squared (0.542). Regressing the MRM- and OLS-mapped utility values upon body mass index and log-viral load gave covariate associations comparable to those estimated from the observed utility data (all P > 0.10). EPM did not achieve this property. Findings from the validation data were similar. Conclusions: Functions are available for mapping the MOS-HIV to the EQ-5D-3 L utility values. MRM and OLS were comparable in terms of agreement with the observed utility values at the individual level. MRM had better performance at the group level in terms of describing the utility distribution. Trial registration: NCT00988039. Registered 30 September 2009.",

keywords = "EQ-5D, Health utility, Mapping, Medical outcomes study HIV health survey",

author = "Yuan Shi and Jennifer Thompson and Walker, {A. Sarah} and Paton, {Nicholas I.} and Cheung, {Yin Bun} and E. Agweng and P. Awio and G. Bakeinyaga and C. Isabirye and U. Kabuga and S. Kasuswa and M. Katuramu and C. Kityo and F. Kiweewa and H. Kyomugisha and E. Lutalo and P. Mugyenyi and D. Mulima and H. Musana and G. Musitwa and V. Musiime and M. Ndigendawan and H. Namata and J. Nkalubo and Labejja, {P. Ocitti} and P. Okello and P. Olal and G. Pimundu and P. Segonga and F. Ssali and Z. Tamale and D. Tumukunde and W. Namala and R. Byaruhanga and J. Kayiwa and J. Tukamushaba and S. Abunyang and D. Eram and O. Denis and R. Lwalanda and L. Mugarura and J. Namusanje and I. Nankya and E. Ndashimye and E. Nabulime and D. Mulima and O. Senfuma and G. Bihabwa and E. Buluma and P. Easterbrook and A. Elbireer and A. Kambugu and D. Kamya and M. Katwere and R. Kiggundu and C. Komujuni and E. Laker and E. Lubwama and I. Mambule and J. Matovu and A. Nakajubi and J. Nakku and R. Nalumenya and L. Namuyimbwa and F. Semitala and B. Wandera and J. Wanyama and H. Mugerwa and A. Lugemwa and E. Ninsiima and T. Ssenkindu and S. Mwebe and L. Atwine and H. William and C. Katemba and S. Abunyang and M. Acaku and P. Ssebutinde and H. Kitizo and J. Kukundakwe and M. Naluguza and K. Ssegawa and F. Nsibuka and P. Tuhirirwe and M. Fortunate and J. Acen and J. Achidri and A. Amone and M. Chamai and J. Ditai and M. Kemigisa and M. Kiconco and C. Matama and D. Mbanza and F. Nambaziira and Odoi, {M. Owor} and A. Rweyora and G. Tumwebaze and H. Kalanzi and J. Katabaazi and A. Kiyingi and M. Mbidde and M. Mugenyi and R. Mwebaze and P. Okong and I. Senoga and M. Abwola and D. Baliruno and J. Bwomezi and A. Kasede and M. Mudoola and R. Namisi and F. Ssennono and S. Tuhirwe and G. Abongomera and G. Amone and J. Abach and I. Aciro and B. Arach and P. Kidega and J. Omongin and E. Ocung and W. Odong and A. Philliam and H. Alima and B. Ahimbisibwe and E. Atuhaire and F. Atukunda and G. Bekusike and A. Bulegyeya and D. Kahatano and S. Kamukama and J. Kyoshabire and A. Nassali and A. Mbonye and Naturinda, {T. M.} and A. Nshabohurira and H. Ntawiha and A. Rogers and M. Tibyasa and S. Kiirya and D. Atwongyeire and A. Nankya and C. Draleku and D. Nakiboneka and D. Odoch and L. Lakidi and R. Ruganda and R. Abiriga and M. Mulindwa and F. Balmoi and S. Kafuma and E. Moriku and J. Hakim and A. Reid and E. Chidziva and G. Musoro and C. Warambwa and G. Tinago and S. Mutsai and M. Phiri and S. Mudzingwa and T. Bafana and V. Masore and C. Moyo and R. Nhema and S. Chitongo and Robert Heyderman and Lucky Kabanga and Symon Kaunda and Aubrey Kudzala and Linly Lifa and Jane Mallewa and Mike Moore and Chrissie Mtali and George Musowa and Grace Mwimaniwa and Rosemary Sikwese and {Van Oosterhout}, Joep and Milton Ziwoya and H. Chimbaka and B. Chitete and S. Kamanga and Makwakwa, {T. Kayinga E.} and R. Mbiya and M. Mlenga and T. Mphande and C. Mtika and G. Mushani and O. Ndhlovu and M. Ngonga and I. Nkhana and R. Nyirenda and P. Cheruiyot and C. Kwobah and Ekiru, {W. Lokitala} and M. Mokaya and A. Mudogo and A. Nzioka and A. Siika and M. Tanui and S. Wachira and K. Wools-Kaloustian and P. Alipalli and E. Chikatula and J. Kipaila and I. Kunda and S. Lakhi and J. Malama and W. Mufwambi and L. Mulenga and P. Mwaba and E. Mwamba and A. Mweemba and M. Namfukwe and E. Kerukadho and B. Ngwatu and J. Birungi and N. Paton and J. Boles and A. Burke and L. Castle and S. Ghuman and L. Kendall and A. Hoppe and S. Tebbs and M. Thomason and J. Thompson and S. Walker and J. Whittle and H. Wilkes and N. Young and C. Kapuya and F. Kyomuhendo and D. Kyakundi and N. Mkandawire and S. Mulambo and S. Senyonjo and B. Angus and A. Arenas-Pinto and A. Palfreeman and F. Post and D. Ishola and J. Arribas and R. Colebunders and M. Floridia and M. Giuliano and P. Mallon and P. Walsh and {De Rosa}, M. and E. Rinaldi and I. Weller and C. Gilks and J. Hakim and A. Kangewende and S. Lakhi and E. Luyirika and F. Miiro and P. Mwamba and P. Mugyenyi and S. Ojoo and N. Paton and S. Phiri and {Van Oosterhout}, J. and A. Siika and S. Walker and A. Wapakabulo and T. Peto and N. French and J. Matenga and G. Cloherty and {Van Wyk}, J. and M. Norton and S. Lehrman and P. Lamba and K. Malik and J. Rooney and W. Snowden and J. Villacian",

note = "Publisher Copyright: {\textcopyright} 2019 The Author(s).",

year = "2019",

month = may,

day = "10",

doi = "10.1186/s12955-019-1135-8",

language = "English (US)",

volume = "17",

journal = "Health and Quality of Life Outcomes",

issn = "1477-7525",

publisher = "BioMed Central",

number = "1",

}

TY - JOUR

T1 - Mapping the medical outcomes study HIV health survey (MOS-HIV) to the EuroQoL 5 Dimension (EQ-5D-3 L) utility index

AU - Shi, Yuan

AU - Thompson, Jennifer

AU - Walker, A. Sarah

AU - Paton, Nicholas I.

AU - Cheung, Yin Bun

AU - Agweng, E.

AU - Awio, P.

AU - Bakeinyaga, G.

AU - Isabirye, C.

AU - Kabuga, U.

AU - Kasuswa, S.

AU - Katuramu, M.

AU - Kityo, C.

AU - Kiweewa, F.

AU - Kyomugisha, H.

AU - Lutalo, E.

AU - Mugyenyi, P.

AU - Mulima, D.

AU - Musana, H.

AU - Musitwa, G.

AU - Musiime, V.

AU - Ndigendawan, M.

AU - Namata, H.

AU - Nkalubo, J.

AU - Labejja, P. Ocitti

AU - Okello, P.

AU - Olal, P.

AU - Pimundu, G.

AU - Segonga, P.

AU - Ssali, F.

AU - Tamale, Z.

AU - Tumukunde, D.

AU - Namala, W.

AU - Byaruhanga, R.

AU - Kayiwa, J.

AU - Tukamushaba, J.

AU - Abunyang, S.

AU - Eram, D.

AU - Denis, O.

AU - Lwalanda, R.

AU - Mugarura, L.

AU - Namusanje, J.

AU - Nankya, I.

AU - Ndashimye, E.

AU - Nabulime, E.

AU - Mulima, D.

AU - Senfuma, O.

AU - Bihabwa, G.

AU - Buluma, E.

AU - Easterbrook, P.

AU - Elbireer, A.

AU - Kambugu, A.

AU - Kamya, D.

AU - Katwere, M.

AU - Kiggundu, R.

AU - Komujuni, C.

AU - Laker, E.

AU - Lubwama, E.

AU - Mambule, I.

AU - Matovu, J.

AU - Nakajubi, A.

AU - Nakku, J.

AU - Nalumenya, R.

AU - Namuyimbwa, L.

AU - Semitala, F.

AU - Wandera, B.

AU - Wanyama, J.

AU - Mugerwa, H.

AU - Lugemwa, A.

AU - Ninsiima, E.

AU - Ssenkindu, T.

AU - Mwebe, S.

AU - Atwine, L.

AU - William, H.

AU - Katemba, C.

AU - Abunyang, S.

AU - Acaku, M.

AU - Ssebutinde, P.

AU - Kitizo, H.

AU - Kukundakwe, J.

AU - Naluguza, M.

AU - Ssegawa, K.

AU - Nsibuka, F.

AU - Tuhirirwe, P.

AU - Fortunate, M.

AU - Acen, J.

AU - Achidri, J.

AU - Amone, A.

AU - Chamai, M.

AU - Ditai, J.

AU - Kemigisa, M.

AU - Kiconco, M.

AU - Matama, C.

AU - Mbanza, D.

AU - Nambaziira, F.

AU - Odoi, M. Owor

AU - Rweyora, A.

AU - Tumwebaze, G.

AU - Kalanzi, H.

AU - Katabaazi, J.

AU - Kiyingi, A.

AU - Mbidde, M.

AU - Mugenyi, M.

AU - Mwebaze, R.

AU - Okong, P.

AU - Senoga, I.

AU - Abwola, M.

AU - Baliruno, D.

AU - Bwomezi, J.

AU - Kasede, A.

AU - Mudoola, M.

AU - Namisi, R.

AU - Ssennono, F.

AU - Tuhirwe, S.

AU - Abongomera, G.

AU - Amone, G.

AU - Abach, J.

AU - Aciro, I.

AU - Arach, B.

AU - Kidega, P.

AU - Omongin, J.

AU - Ocung, E.

AU - Odong, W.

AU - Philliam, A.

AU - Alima, H.

AU - Ahimbisibwe, B.

AU - Atuhaire, E.

AU - Atukunda, F.

AU - Bekusike, G.

AU - Bulegyeya, A.

AU - Kahatano, D.

AU - Kamukama, S.

AU - Kyoshabire, J.

AU - Nassali, A.

AU - Mbonye, A.

AU - Naturinda, T. M.

AU - Nshabohurira, A.

AU - Ntawiha, H.

AU - Rogers, A.

AU - Tibyasa, M.

AU - Kiirya, S.

AU - Atwongyeire, D.

AU - Nankya, A.

AU - Draleku, C.

AU - Nakiboneka, D.

AU - Odoch, D.

AU - Lakidi, L.

AU - Ruganda, R.

AU - Abiriga, R.

AU - Mulindwa, M.

AU - Balmoi, F.

AU - Kafuma, S.

AU - Moriku, E.

AU - Hakim, J.

AU - Reid, A.

AU - Chidziva, E.

AU - Musoro, G.

AU - Warambwa, C.

AU - Tinago, G.

AU - Mutsai, S.

AU - Phiri, M.

AU - Mudzingwa, S.

AU - Bafana, T.

AU - Masore, V.

AU - Moyo, C.

AU - Nhema, R.

AU - Chitongo, S.

AU - Heyderman, Robert

AU - Kabanga, Lucky

AU - Kaunda, Symon

AU - Kudzala, Aubrey

AU - Lifa, Linly

AU - Mallewa, Jane

AU - Moore, Mike

AU - Mtali, Chrissie

AU - Musowa, George

AU - Mwimaniwa, Grace

AU - Sikwese, Rosemary

AU - Van Oosterhout, Joep

AU - Ziwoya, Milton

AU - Chimbaka, H.

AU - Chitete, B.

AU - Kamanga, S.

AU - Makwakwa, T. Kayinga E.

AU - Mbiya, R.

AU - Mlenga, M.

AU - Mphande, T.

AU - Mtika, C.

AU - Mushani, G.

AU - Ndhlovu, O.

AU - Ngonga, M.

AU - Nkhana, I.

AU - Nyirenda, R.

AU - Cheruiyot, P.

AU - Kwobah, C.

AU - Ekiru, W. Lokitala

AU - Mokaya, M.

AU - Mudogo, A.

AU - Nzioka, A.

AU - Siika, A.

AU - Tanui, M.

AU - Wachira, S.

AU - Wools-Kaloustian, K.

AU - Alipalli, P.

AU - Chikatula, E.

AU - Kipaila, J.

AU - Kunda, I.

AU - Lakhi, S.

AU - Malama, J.

AU - Mufwambi, W.

AU - Mulenga, L.

AU - Mwaba, P.

AU - Mwamba, E.

AU - Mweemba, A.

AU - Namfukwe, M.

AU - Kerukadho, E.

AU - Ngwatu, B.

AU - Birungi, J.

AU - Paton, N.

AU - Boles, J.

AU - Burke, A.

AU - Castle, L.

AU - Ghuman, S.

AU - Kendall, L.

AU - Hoppe, A.

AU - Tebbs, S.

AU - Thomason, M.

AU - Thompson, J.

AU - Walker, S.

AU - Whittle, J.

AU - Wilkes, H.

AU - Young, N.

AU - Kapuya, C.

AU - Kyomuhendo, F.

AU - Kyakundi, D.

AU - Mkandawire, N.

AU - Mulambo, S.

AU - Senyonjo, S.

AU - Angus, B.

AU - Arenas-Pinto, A.

AU - Palfreeman, A.

AU - Post, F.

AU - Ishola, D.

AU - Arribas, J.

AU - Colebunders, R.

AU - Floridia, M.

AU - Giuliano, M.

AU - Mallon, P.

AU - Walsh, P.

AU - De Rosa, M.

AU - Rinaldi, E.

AU - Weller, I.

AU - Gilks, C.

AU - Hakim, J.

AU - Kangewende, A.

AU - Lakhi, S.

AU - Luyirika, E.

AU - Miiro, F.

AU - Mwamba, P.

AU - Mugyenyi, P.

AU - Ojoo, S.

AU - Paton, N.

AU - Phiri, S.

AU - Van Oosterhout, J.

AU - Siika, A.

AU - Walker, S.

AU - Wapakabulo, A.

AU - Peto, T.

AU - French, N.

AU - Matenga, J.

AU - Cloherty, G.

AU - Van Wyk, J.

AU - Norton, M.

AU - Lehrman, S.

AU - Lamba, P.

AU - Malik, K.

AU - Rooney, J.

AU - Snowden, W.

AU - Villacian, J.

PY - 2019/5/10

Y1 - 2019/5/10

N2 - Background: Mapping of health-related quality-of-life measures to health utility values can facilitate cost-utility evaluation. Regression-based methods tend to lead to shrinkage of variance. This study aims to map the Medical Outcomes Study HIV Health Survey (MOS-HIV) to EuroQoL 5 Dimensions (EQ-5D-3 L) utility index, and to characterize the performance of three mapping methods, including ordinary least squares (OLS), equi-percentile method (EPM), and a recently proposed method called Mean Rank Method (MRM). Methods: This is a secondary analysis of data from a randomized HIV treatment trial. Baseline data from 421 participants were used to develop mapping functions. Follow-up data from 236 participants was used to validate the mapping functions. Results: In the training dataset, MRM and OLS, but not EPM, reproduced the observed mean utility (0.731). MRM, OLS and EPM under-estimated the standard deviation by 0.3, 26.6 and 1.7%, respectively. MRM had the lowest mean absolute error (0.143) and highest intraclass correlation coefficient (0.723) with the observed utility values, whereas OLS had the lowest mean squared error (0.038) and highest R-squared (0.542). Regressing the MRM- and OLS-mapped utility values upon body mass index and log-viral load gave covariate associations comparable to those estimated from the observed utility data (all P > 0.10). EPM did not achieve this property. Findings from the validation data were similar. Conclusions: Functions are available for mapping the MOS-HIV to the EQ-5D-3 L utility values. MRM and OLS were comparable in terms of agreement with the observed utility values at the individual level. MRM had better performance at the group level in terms of describing the utility distribution. Trial registration: NCT00988039. Registered 30 September 2009.

AB - Background: Mapping of health-related quality-of-life measures to health utility values can facilitate cost-utility evaluation. Regression-based methods tend to lead to shrinkage of variance. This study aims to map the Medical Outcomes Study HIV Health Survey (MOS-HIV) to EuroQoL 5 Dimensions (EQ-5D-3 L) utility index, and to characterize the performance of three mapping methods, including ordinary least squares (OLS), equi-percentile method (EPM), and a recently proposed method called Mean Rank Method (MRM). Methods: This is a secondary analysis of data from a randomized HIV treatment trial. Baseline data from 421 participants were used to develop mapping functions. Follow-up data from 236 participants was used to validate the mapping functions. Results: In the training dataset, MRM and OLS, but not EPM, reproduced the observed mean utility (0.731). MRM, OLS and EPM under-estimated the standard deviation by 0.3, 26.6 and 1.7%, respectively. MRM had the lowest mean absolute error (0.143) and highest intraclass correlation coefficient (0.723) with the observed utility values, whereas OLS had the lowest mean squared error (0.038) and highest R-squared (0.542). Regressing the MRM- and OLS-mapped utility values upon body mass index and log-viral load gave covariate associations comparable to those estimated from the observed utility data (all P > 0.10). EPM did not achieve this property. Findings from the validation data were similar. Conclusions: Functions are available for mapping the MOS-HIV to the EQ-5D-3 L utility values. MRM and OLS were comparable in terms of agreement with the observed utility values at the individual level. MRM had better performance at the group level in terms of describing the utility distribution. Trial registration: NCT00988039. Registered 30 September 2009.

KW - EQ-5D

KW - Health utility

KW - Mapping

KW - Medical outcomes study HIV health survey

UR - http://www.scopus.com/inward/record.url?scp=85065604348&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85065604348&partnerID=8YFLogxK

U2 - 10.1186/s12955-019-1135-8

DO - 10.1186/s12955-019-1135-8

M3 - Article

C2 - 31077251

AN - SCOPUS:85065604348

SN - 1477-7525

VL - 17

JO - Health and Quality of Life Outcomes

JF - Health and Quality of Life Outcomes

IS - 1

M1 - 83

ER -

Mapping the medical outcomes study HIV health survey (MOS-HIV) to the EuroQoL 5 Dimension (EQ-5D-3 L) utility index

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