Mapping the effects of ApoE4, age and cognitive status on 18F-florbetapir PET measured regional cortical patterns of beta-amyloid density and growth

Kelly R. Murphy, Susan M. Landau, Kingshuk Roy Choudhury, Christopher A. Hostage, Katie S. Shpanskaya, Haris Sair, Jeffrey R. Petrella, Terence Z. Wong, P. Murali Doraiswamy

Research output: Contribution to journalArticle

Abstract

Background: Although it is well known that many clinical and genetic factors have been associated with beta-amyloid deposition, few studies have examined the interactions of such factors across different stages of Alzheimer's pathogenesis. Methods: We used 18F-florbetapir F18 PET imaging to quantify neuritic beta-amyloid plaque density across four cortical regions in 602 elderly (55-94. years) subjects from the national ADNI biomarker study. The group comprised of 194 normal elderly, 212 early mild cognitive impairment [EMCI], 132 late mild cognitive impairment [LMCI], and 64 mild Alzheimer's (AD). Findings: In a model incorporating multiple predictive factors, the effect of apolipoprotein E ε4 and diagnosis was significant on all four cortical regions. The highest signals were seen in cingulate followed by frontal and parietal with lowest signals in temporal lobe (p.

Original languageEnglish (US)
Pages (from-to)474-480
Number of pages7
JournalNeuroImage
Volume78
DOIs
StatePublished - Sep 2013

Fingerprint

Apolipoprotein E4
Amyloid
Amyloid Plaques
Temporal Lobe
Growth
Biomarkers
Cognitive Dysfunction
florbetapir

Keywords

  • 18F-florbetapir PET
  • Alzheimer's disease
  • ApoE4
  • Beta-amyloid deposition

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology

Cite this

Mapping the effects of ApoE4, age and cognitive status on 18F-florbetapir PET measured regional cortical patterns of beta-amyloid density and growth. / Murphy, Kelly R.; Landau, Susan M.; Choudhury, Kingshuk Roy; Hostage, Christopher A.; Shpanskaya, Katie S.; Sair, Haris; Petrella, Jeffrey R.; Wong, Terence Z.; Doraiswamy, P. Murali.

In: NeuroImage, Vol. 78, 09.2013, p. 474-480.

Research output: Contribution to journalArticle

Murphy, Kelly R. ; Landau, Susan M. ; Choudhury, Kingshuk Roy ; Hostage, Christopher A. ; Shpanskaya, Katie S. ; Sair, Haris ; Petrella, Jeffrey R. ; Wong, Terence Z. ; Doraiswamy, P. Murali. / Mapping the effects of ApoE4, age and cognitive status on 18F-florbetapir PET measured regional cortical patterns of beta-amyloid density and growth. In: NeuroImage. 2013 ; Vol. 78. pp. 474-480.
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