Mapping the distribution of amobarbital sodium in the intracarotid Wada test by use of Tc-99m HMPAO with SPECT

Petra J. Jeffery, Lee H. Monsein, Zsolt Szabo, John Hart, Robert S. Fisher, Ronald P Lesser, Gerard M. Debrun, Barry Gordon, Henry N. Wagner, Edwaldo E. Camargo

Research output: Contribution to journalArticle

Abstract

The intracarotid amobarbital sodium, or Wada, test has been used to localize speech and memory function prior to surgical treatment of temporal lobe seizures. The authors mixed technetium-99m hexamethylpropyleneamine oxime (HMPAO) with amobarbital sodium and injected the mixture in 25 patients with epilepsy. Single photon emission computed tomography (SPECT) of the brain was then performed to determine intracerebral distribution of the amobarbital sodium. Results of SPECT were compared with those of conventional and digital subtraction angiography (DSA). The distribution of Tc-99m HMPAO and, presumably, amobarbital sodium varied from patient to patient. SPECT revealed a statistically different distribution from that predicted with conventional angiography. The distribution also often differed from that of DSA, although the difference was not significant. SPECT revealed infrequent delivery to mesial temporal lobe structures. This emphasizes the need for caution in the use of the intracarotid amobarbital sodium test to predict the outcome of removal of these areas.

Original languageEnglish (US)
Pages (from-to)847-850
Number of pages4
JournalRadiology
Volume178
Issue number3
StatePublished - Mar 1991

Fingerprint

Technetium Tc 99m Exametazime
Amobarbital
Single-Photon Emission-Computed Tomography
Digital Subtraction Angiography
Temporal Lobe
Technetium
Operative Time
Epilepsy
Angiography
Seizures
Brain

Keywords

  • Angiography, preoperative, 17.124
  • Brain, perfusion, 134.89
  • Cerebral blood vessels, radionuclide studies, 17.1299
  • Emission CT
  • Epilepsy, 134.89
  • Radionuclide imaging, comparative studies

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Jeffery, P. J., Monsein, L. H., Szabo, Z., Hart, J., Fisher, R. S., Lesser, R. P., ... Camargo, E. E. (1991). Mapping the distribution of amobarbital sodium in the intracarotid Wada test by use of Tc-99m HMPAO with SPECT. Radiology, 178(3), 847-850.

Mapping the distribution of amobarbital sodium in the intracarotid Wada test by use of Tc-99m HMPAO with SPECT. / Jeffery, Petra J.; Monsein, Lee H.; Szabo, Zsolt; Hart, John; Fisher, Robert S.; Lesser, Ronald P; Debrun, Gerard M.; Gordon, Barry; Wagner, Henry N.; Camargo, Edwaldo E.

In: Radiology, Vol. 178, No. 3, 03.1991, p. 847-850.

Research output: Contribution to journalArticle

Jeffery, PJ, Monsein, LH, Szabo, Z, Hart, J, Fisher, RS, Lesser, RP, Debrun, GM, Gordon, B, Wagner, HN & Camargo, EE 1991, 'Mapping the distribution of amobarbital sodium in the intracarotid Wada test by use of Tc-99m HMPAO with SPECT', Radiology, vol. 178, no. 3, pp. 847-850.
Jeffery, Petra J. ; Monsein, Lee H. ; Szabo, Zsolt ; Hart, John ; Fisher, Robert S. ; Lesser, Ronald P ; Debrun, Gerard M. ; Gordon, Barry ; Wagner, Henry N. ; Camargo, Edwaldo E. / Mapping the distribution of amobarbital sodium in the intracarotid Wada test by use of Tc-99m HMPAO with SPECT. In: Radiology. 1991 ; Vol. 178, No. 3. pp. 847-850.
@article{20b94a5141b74b28a0386a11c6c9f2b6,
title = "Mapping the distribution of amobarbital sodium in the intracarotid Wada test by use of Tc-99m HMPAO with SPECT",
abstract = "The intracarotid amobarbital sodium, or Wada, test has been used to localize speech and memory function prior to surgical treatment of temporal lobe seizures. The authors mixed technetium-99m hexamethylpropyleneamine oxime (HMPAO) with amobarbital sodium and injected the mixture in 25 patients with epilepsy. Single photon emission computed tomography (SPECT) of the brain was then performed to determine intracerebral distribution of the amobarbital sodium. Results of SPECT were compared with those of conventional and digital subtraction angiography (DSA). The distribution of Tc-99m HMPAO and, presumably, amobarbital sodium varied from patient to patient. SPECT revealed a statistically different distribution from that predicted with conventional angiography. The distribution also often differed from that of DSA, although the difference was not significant. SPECT revealed infrequent delivery to mesial temporal lobe structures. This emphasizes the need for caution in the use of the intracarotid amobarbital sodium test to predict the outcome of removal of these areas.",
keywords = "Angiography, preoperative, 17.124, Brain, perfusion, 134.89, Cerebral blood vessels, radionuclide studies, 17.1299, Emission CT, Epilepsy, 134.89, Radionuclide imaging, comparative studies",
author = "Jeffery, {Petra J.} and Monsein, {Lee H.} and Zsolt Szabo and John Hart and Fisher, {Robert S.} and Lesser, {Ronald P} and Debrun, {Gerard M.} and Barry Gordon and Wagner, {Henry N.} and Camargo, {Edwaldo E.}",
year = "1991",
month = "3",
language = "English (US)",
volume = "178",
pages = "847--850",
journal = "Radiology",
issn = "0033-8419",
publisher = "Radiological Society of North America Inc.",
number = "3",

}

TY - JOUR

T1 - Mapping the distribution of amobarbital sodium in the intracarotid Wada test by use of Tc-99m HMPAO with SPECT

AU - Jeffery, Petra J.

AU - Monsein, Lee H.

AU - Szabo, Zsolt

AU - Hart, John

AU - Fisher, Robert S.

AU - Lesser, Ronald P

AU - Debrun, Gerard M.

AU - Gordon, Barry

AU - Wagner, Henry N.

AU - Camargo, Edwaldo E.

PY - 1991/3

Y1 - 1991/3

N2 - The intracarotid amobarbital sodium, or Wada, test has been used to localize speech and memory function prior to surgical treatment of temporal lobe seizures. The authors mixed technetium-99m hexamethylpropyleneamine oxime (HMPAO) with amobarbital sodium and injected the mixture in 25 patients with epilepsy. Single photon emission computed tomography (SPECT) of the brain was then performed to determine intracerebral distribution of the amobarbital sodium. Results of SPECT were compared with those of conventional and digital subtraction angiography (DSA). The distribution of Tc-99m HMPAO and, presumably, amobarbital sodium varied from patient to patient. SPECT revealed a statistically different distribution from that predicted with conventional angiography. The distribution also often differed from that of DSA, although the difference was not significant. SPECT revealed infrequent delivery to mesial temporal lobe structures. This emphasizes the need for caution in the use of the intracarotid amobarbital sodium test to predict the outcome of removal of these areas.

AB - The intracarotid amobarbital sodium, or Wada, test has been used to localize speech and memory function prior to surgical treatment of temporal lobe seizures. The authors mixed technetium-99m hexamethylpropyleneamine oxime (HMPAO) with amobarbital sodium and injected the mixture in 25 patients with epilepsy. Single photon emission computed tomography (SPECT) of the brain was then performed to determine intracerebral distribution of the amobarbital sodium. Results of SPECT were compared with those of conventional and digital subtraction angiography (DSA). The distribution of Tc-99m HMPAO and, presumably, amobarbital sodium varied from patient to patient. SPECT revealed a statistically different distribution from that predicted with conventional angiography. The distribution also often differed from that of DSA, although the difference was not significant. SPECT revealed infrequent delivery to mesial temporal lobe structures. This emphasizes the need for caution in the use of the intracarotid amobarbital sodium test to predict the outcome of removal of these areas.

KW - Angiography, preoperative, 17.124

KW - Brain, perfusion, 134.89

KW - Cerebral blood vessels, radionuclide studies, 17.1299

KW - Emission CT

KW - Epilepsy, 134.89

KW - Radionuclide imaging, comparative studies

UR - http://www.scopus.com/inward/record.url?scp=0026099143&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026099143&partnerID=8YFLogxK

M3 - Article

C2 - 1994430

AN - SCOPUS:0026099143

VL - 178

SP - 847

EP - 850

JO - Radiology

JF - Radiology

SN - 0033-8419

IS - 3

ER -