Mapping postnatal mouse brain development with diffusion tensor microimaging

Jiangyang Zhang, Michael I. Miller, Celine Plachez, Linda J. Richards, Paul Yarowsky, Peter Van Zijl, Susumu Mori

Research output: Contribution to journalArticlepeer-review

Abstract

While mouse brain development has been extensively studied using histology, quantitative characterization of morphological changes is still a challenging task. This paper presents how developing brain structures can be quantitatively characterized with magnetic resonance diffusion tensor microimaging coupled with techniques of computational anatomy. High resolution diffusion tensor images of ex vivo postnatal mouse brains provide excellent contrasts to reveal the evolutions of mouse forebrain structures. Using anatomical landmarks defined on diffusion tensor images, tissue level growth patterns of mouse brains were quantified. The results demonstrate the use of these techniques to three-dimensionally and quantitatively characterize brain growth.

Original languageEnglish (US)
Pages (from-to)1042-1051
Number of pages10
JournalNeuroImage
Volume26
Issue number4
DOIs
StatePublished - Jul 15 2005

Keywords

  • Computational neuroanatomy
  • Diffusion tensor
  • Microimaging
  • Mouse brain development

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

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