Mapping of the gene for the tyrosine kinase itk to a region of conserved synteny between mouse chromosome 11 and human chromosome 5q

Eric M. Janis; Janet D. Slliciano; Daniel D. Isaac; Constance A. Griffin; Anita L. Hawkins; Christine A. Kozak; Stephen Desiderio

doi:10.1006/geno.1994.1492

Mapping of the gene for the tyrosine kinase itk to a region of conserved synteny between mouse chromosome 11 and human chromosome 5q

Eric M. Janis, Janet D. Slliciano, Daniel D. Isaac, Constance A. Griffin, Anita L. Hawkins, Christine A. Kozak, Stephen Desiderio

School of Medicine

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The protein-tyrosine kinase gene Itk is expressed preferentially in T lymphoid cells of the mouse and is induced by IL-2. A related gene, Btk, is expressed in the murine B lymphoid and myeloid lineages. Because mutations in Btk and the corresponding human gene are associated with X-linked immunodeficiency syndromes, it was of interest to map Itk and its human counterpart. By Southern blot analysis of DNA from the progeny of two multilocus crosses, murine Itk was mapped to Chromosome 11. By fluorescence in situ hybridization, human ITK was mapped to 5q32-q33. Murine Itk and its human homologue lie within regions of conserved synteny that include several growth factor and growth factor receptor genes. This region in humans is frequently deleted in the myelodysplastic syndrome, suggesting possible involvement of ITK in this disorder.

Original language	English (US)
Pages (from-to)	269-271
Number of pages	3
Journal	Genomics
Volume	23
Issue number	1
DOIs	https://doi.org/10.1006/geno.1994.1492
State	Published - Sep 1 1994

ASJC Scopus subject areas

Genetics

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title = "Mapping of the gene for the tyrosine kinase itk to a region of conserved synteny between mouse chromosome 11 and human chromosome 5q",

abstract = "The protein-tyrosine kinase gene Itk is expressed preferentially in T lymphoid cells of the mouse and is induced by IL-2. A related gene, Btk, is expressed in the murine B lymphoid and myeloid lineages. Because mutations in Btk and the corresponding human gene are associated with X-linked immunodeficiency syndromes, it was of interest to map Itk and its human counterpart. By Southern blot analysis of DNA from the progeny of two multilocus crosses, murine Itk was mapped to Chromosome 11. By fluorescence in situ hybridization, human ITK was mapped to 5q32-q33. Murine Itk and its human homologue lie within regions of conserved synteny that include several growth factor and growth factor receptor genes. This region in humans is frequently deleted in the myelodysplastic syndrome, suggesting possible involvement of ITK in this disorder.",

author = "Janis, {Eric M.} and Slliciano, {Janet D.} and Isaac, {Daniel D.} and Griffin, {Constance A.} and Hawkins, {Anita L.} and Kozak, {Christine A.} and Stephen Desiderio",

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T1 - Mapping of the gene for the tyrosine kinase itk to a region of conserved synteny between mouse chromosome 11 and human chromosome 5q

AU - Janis, Eric M.

AU - Slliciano, Janet D.

AU - Isaac, Daniel D.

AU - Griffin, Constance A.

AU - Hawkins, Anita L.

AU - Kozak, Christine A.

AU - Desiderio, Stephen

PY - 1994/9/1

Y1 - 1994/9/1

N2 - The protein-tyrosine kinase gene Itk is expressed preferentially in T lymphoid cells of the mouse and is induced by IL-2. A related gene, Btk, is expressed in the murine B lymphoid and myeloid lineages. Because mutations in Btk and the corresponding human gene are associated with X-linked immunodeficiency syndromes, it was of interest to map Itk and its human counterpart. By Southern blot analysis of DNA from the progeny of two multilocus crosses, murine Itk was mapped to Chromosome 11. By fluorescence in situ hybridization, human ITK was mapped to 5q32-q33. Murine Itk and its human homologue lie within regions of conserved synteny that include several growth factor and growth factor receptor genes. This region in humans is frequently deleted in the myelodysplastic syndrome, suggesting possible involvement of ITK in this disorder.

AB - The protein-tyrosine kinase gene Itk is expressed preferentially in T lymphoid cells of the mouse and is induced by IL-2. A related gene, Btk, is expressed in the murine B lymphoid and myeloid lineages. Because mutations in Btk and the corresponding human gene are associated with X-linked immunodeficiency syndromes, it was of interest to map Itk and its human counterpart. By Southern blot analysis of DNA from the progeny of two multilocus crosses, murine Itk was mapped to Chromosome 11. By fluorescence in situ hybridization, human ITK was mapped to 5q32-q33. Murine Itk and its human homologue lie within regions of conserved synteny that include several growth factor and growth factor receptor genes. This region in humans is frequently deleted in the myelodysplastic syndrome, suggesting possible involvement of ITK in this disorder.

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Mapping of the gene for the tyrosine kinase itk to a region of conserved synteny between mouse chromosome 11 and human chromosome 5q

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