Mapping of simian virus 40 early functions on the viral chromosome

J. F. Morrow, P. Berg, Thomas Kelly, A. M. Lewis

Research output: Contribution to journalArticle

Abstract

The simian virus 40 (SV40) DNA segment in the nondefective adenovirus 2 SV40 hybrid, Ad2+ND4, is colinear with the segment between 0.11 and 0.59 SV40 fractional length from the site at which the R1 restriction endonuclease cleaves SV40 DNA. This specifies the region of the SV40 DNA molecule which induces the early SV40 antigens: U antigen, tumor specific transplantation antigen, and T antigen. A variant of Ad2+ND4, called Ad2+ND(4del), was found which has a deletion of the DNA segment between 0.50 and 0.57 SV40 fractional length from the R1 endonuclease cleavage point.

Original languageEnglish (US)
Pages (from-to)653-658
Number of pages6
JournalJournal of Virology
Volume12
Issue number3
StatePublished - 1973
Externally publishedYes

Fingerprint

Simian virus 40
Chromosomes
chromosomes
antigens
DNA
Antigens
Endonucleases
Viral Tumor Antigens
DNA Restriction Enzymes
restriction endonucleases
Adenoviridae
neoplasms

ASJC Scopus subject areas

  • Immunology

Cite this

Morrow, J. F., Berg, P., Kelly, T., & Lewis, A. M. (1973). Mapping of simian virus 40 early functions on the viral chromosome. Journal of Virology, 12(3), 653-658.

Mapping of simian virus 40 early functions on the viral chromosome. / Morrow, J. F.; Berg, P.; Kelly, Thomas; Lewis, A. M.

In: Journal of Virology, Vol. 12, No. 3, 1973, p. 653-658.

Research output: Contribution to journalArticle

Morrow, JF, Berg, P, Kelly, T & Lewis, AM 1973, 'Mapping of simian virus 40 early functions on the viral chromosome', Journal of Virology, vol. 12, no. 3, pp. 653-658.
Morrow, J. F. ; Berg, P. ; Kelly, Thomas ; Lewis, A. M. / Mapping of simian virus 40 early functions on the viral chromosome. In: Journal of Virology. 1973 ; Vol. 12, No. 3. pp. 653-658.
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