Mapping, modeling, and visual exploration of structure-function relationships in the heart

Raimond Winslow, D. F. Scollan, J. L. Greenstein, C. K. Yung, William A Baumgartner, G. Bhanot, D. L. Gresh, B. E. Rogowitz

Research output: Contribution to journalArticle

Abstract

It is becoming clear that the emergent, integrative behaviors of biological systems result from complex interactions between all system components, and that knowledge of each component is not sufficient to understand such behaviors. In this paper, we describe our approach to the integrative modeling of cardiac function. This approach spans multiple levels of biological analysis, ranging from subcellular to tissue. We have applied diverse analytical methods, including imaging techniques for measurement of anatomic structure and biophysical and biochemical responses of cells and tissue, parallel computing techniques for the numerical solution of large systems of model equations, and interactive visual exploration of model dynamic behavior.

Original languageEnglish (US)
Pages (from-to)342-359
Number of pages18
JournalIBM Systems Journal
Volume40
Issue number2
StatePublished - 2001

Fingerprint

Structure-function
Tissue
Emergent Behavior
Biological systems
Parallel processing systems
Parallel Computing
Modeling
Analytical Methods
Biological Systems
Cardiac
Dynamic Behavior
Dynamic models
Imaging
Numerical Solution
Sufficient
Imaging techniques
Cell
Interaction
Model
Relationships

ASJC Scopus subject areas

  • Information Systems
  • Computer Graphics and Computer-Aided Design
  • Software
  • Theoretical Computer Science
  • Computational Theory and Mathematics

Cite this

Winslow, R., Scollan, D. F., Greenstein, J. L., Yung, C. K., Baumgartner, W. A., Bhanot, G., ... Rogowitz, B. E. (2001). Mapping, modeling, and visual exploration of structure-function relationships in the heart. IBM Systems Journal, 40(2), 342-359.

Mapping, modeling, and visual exploration of structure-function relationships in the heart. / Winslow, Raimond; Scollan, D. F.; Greenstein, J. L.; Yung, C. K.; Baumgartner, William A; Bhanot, G.; Gresh, D. L.; Rogowitz, B. E.

In: IBM Systems Journal, Vol. 40, No. 2, 2001, p. 342-359.

Research output: Contribution to journalArticle

Winslow, R, Scollan, DF, Greenstein, JL, Yung, CK, Baumgartner, WA, Bhanot, G, Gresh, DL & Rogowitz, BE 2001, 'Mapping, modeling, and visual exploration of structure-function relationships in the heart', IBM Systems Journal, vol. 40, no. 2, pp. 342-359.
Winslow, Raimond ; Scollan, D. F. ; Greenstein, J. L. ; Yung, C. K. ; Baumgartner, William A ; Bhanot, G. ; Gresh, D. L. ; Rogowitz, B. E. / Mapping, modeling, and visual exploration of structure-function relationships in the heart. In: IBM Systems Journal. 2001 ; Vol. 40, No. 2. pp. 342-359.
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