Mapping imported malaria in Bangladesh using parasite genetic and human mobility data

Hsiao Han Chang, Amy Wesolowski, Ipsita Sinha, Christopher G. Jacob, Ayesha Mahmud, Didar Uddin, Sazid Ibna Zaman, Md Amir Hossain, M. Abul Faiz, Aniruddha Ghose, Abdullah Abu Sayeed, M. Ridwanur Rahman, Akramul Islam, Mohammad Jahirul Karim, M. Kamar Rezwan, Abul Khair Mohammad Shamsuzzaman, Sanya Tahmina Jhora, M. M. Aktaruzzaman, Eleanor Drury, Sonia GonçalvesMihir Kekre, Mehul Dhorda, Ranitha Vongpromek, Olivo Miotto, Kenth Engø-Monsen, Dominic Kwiatkowski, Richard J. Maude, Caroline Buckee

Research output: Contribution to journalArticle

Abstract

For countries aiming for malaria elimination, travel of infected individuals between endemic areas undermines local interventions. Quantifying parasite importation has therefore become a priority for national control programs. We analyzed epidemiological surveillance data, travel surveys, parasite genetic data, and anonymized mobile phone data to measure the spatial spread of malaria parasites in southeast Bangladesh. We developed a genetic mixing index to estimate the likelihood of samples being local or imported from parasite genetic data and inferred the direction and intensity of parasite flow between locations using an epidemiological model integrating the travel survey and mobile phone calling data. Our approach indicates that, contrary to dogma, frequent mixing occurs in low transmission regions in the southwest, and elimination will require interventions in addition to reducing imported infections from forested regions. Unlike risk maps generated from clinical case counts alone, therefore, our approach distinguishes areas of frequent importation as well as high transmission.

Original languageEnglish (US)
JournaleLife
Volume8
DOIs
StatePublished - Apr 2 2019

Fingerprint

Bangladesh
Medical Genetics
Malaria
Parasites
Cell Phones
Mobile phones
Infection

Keywords

  • epidemiology
  • genetic barcodes
  • global health
  • importation
  • mobility
  • P. falciparum
  • parasite flow
  • travel survey

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Mapping imported malaria in Bangladesh using parasite genetic and human mobility data. / Chang, Hsiao Han; Wesolowski, Amy; Sinha, Ipsita; Jacob, Christopher G.; Mahmud, Ayesha; Uddin, Didar; Zaman, Sazid Ibna; Hossain, Md Amir; Faiz, M. Abul; Ghose, Aniruddha; Sayeed, Abdullah Abu; Rahman, M. Ridwanur; Islam, Akramul; Karim, Mohammad Jahirul; Rezwan, M. Kamar; Shamsuzzaman, Abul Khair Mohammad; Jhora, Sanya Tahmina; Aktaruzzaman, M. M.; Drury, Eleanor; Gonçalves, Sonia; Kekre, Mihir; Dhorda, Mehul; Vongpromek, Ranitha; Miotto, Olivo; Engø-Monsen, Kenth; Kwiatkowski, Dominic; Maude, Richard J.; Buckee, Caroline.

In: eLife, Vol. 8, 02.04.2019.

Research output: Contribution to journalArticle

Chang, HH, Wesolowski, A, Sinha, I, Jacob, CG, Mahmud, A, Uddin, D, Zaman, SI, Hossain, MA, Faiz, MA, Ghose, A, Sayeed, AA, Rahman, MR, Islam, A, Karim, MJ, Rezwan, MK, Shamsuzzaman, AKM, Jhora, ST, Aktaruzzaman, MM, Drury, E, Gonçalves, S, Kekre, M, Dhorda, M, Vongpromek, R, Miotto, O, Engø-Monsen, K, Kwiatkowski, D, Maude, RJ & Buckee, C 2019, 'Mapping imported malaria in Bangladesh using parasite genetic and human mobility data', eLife, vol. 8. https://doi.org/10.7554/eLife.43481
Chang, Hsiao Han ; Wesolowski, Amy ; Sinha, Ipsita ; Jacob, Christopher G. ; Mahmud, Ayesha ; Uddin, Didar ; Zaman, Sazid Ibna ; Hossain, Md Amir ; Faiz, M. Abul ; Ghose, Aniruddha ; Sayeed, Abdullah Abu ; Rahman, M. Ridwanur ; Islam, Akramul ; Karim, Mohammad Jahirul ; Rezwan, M. Kamar ; Shamsuzzaman, Abul Khair Mohammad ; Jhora, Sanya Tahmina ; Aktaruzzaman, M. M. ; Drury, Eleanor ; Gonçalves, Sonia ; Kekre, Mihir ; Dhorda, Mehul ; Vongpromek, Ranitha ; Miotto, Olivo ; Engø-Monsen, Kenth ; Kwiatkowski, Dominic ; Maude, Richard J. ; Buckee, Caroline. / Mapping imported malaria in Bangladesh using parasite genetic and human mobility data. In: eLife. 2019 ; Vol. 8.
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