Mapping homeostatic synaptic plasticity using cable properties of dendrites

B. N. Queenan, K. J. Lee, H. Tan, Richard L Huganir, S. Vicini, D. T S Pak

Research output: Contribution to journalArticle

Abstract

When chronically silenced, cortical and hippocampal neurons homeostatically upregulate excitatory synaptic function. However, the subcellular position of such changes on the dendritic tree is not clear. We exploited the cable-filtering properties of dendrites to derive a parameter, the dendritic filtering index (DFI), to map the spatial distribution of synaptic currents. Our analysis indicates that young rat cortical neurons globally scale AMPA receptor-mediated currents, while mature hippocampal neurons do not, revealing distinct homeostatic strategies between brain regions and developmental stages. The DFI presents a useful tool for mapping the dendritic origin of synaptic currents and the location of synaptic plasticity changes.

Original languageEnglish (US)
Pages (from-to)206-216
Number of pages11
JournalNeuroscience
Volume315
DOIs
StatePublished - Feb 19 2016

Fingerprint

Neuronal Plasticity
Dendrites
Neurons
AMPA Receptors
Up-Regulation
Brain

Keywords

  • AMPA receptors
  • Current shape
  • Dendritic filtering index
  • Dendritic origin
  • Homeostatic synaptic plasticity
  • mEPSC slope

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Mapping homeostatic synaptic plasticity using cable properties of dendrites. / Queenan, B. N.; Lee, K. J.; Tan, H.; Huganir, Richard L; Vicini, S.; Pak, D. T S.

In: Neuroscience, Vol. 315, 19.02.2016, p. 206-216.

Research output: Contribution to journalArticle

Queenan, B. N. ; Lee, K. J. ; Tan, H. ; Huganir, Richard L ; Vicini, S. ; Pak, D. T S. / Mapping homeostatic synaptic plasticity using cable properties of dendrites. In: Neuroscience. 2016 ; Vol. 315. pp. 206-216.
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