Mapping for dyslexia and related cognitive trait loci provides strong evidence for further risk genes on chromosome 6p21

Inke R. König, Johannes Schumacher, Per Hoffmann, Andre Kleensang, Kerstin U. Ludwig, Tiemo Grimm, Nina Neuhoff, Maike Preis, Darina Roeske, Andreas Warnke, Peter Propping, Helmut Remschmidt, Markus M. Nöthen, Andreas Ziegler, Bertram Müller-Myhsok, Gerd Schulte-Körne

Research output: Contribution to journalArticle

Abstract

In a genome-wide linkage scan, we aimed at mapping risk loci for dyslexia in the German population. Our sample comprised 1,030 individuals from 246 dyslexia families which were recruited through a single-proband sib pair study design and a detailed assessment of dyslexia and related cognitive traits. We found evidence for a major dyslexia locus on chromosome 6p21. The cognitive trait rapid naming (objects/colors) produced a genome-wide significant LOD score of 5.87 (P=1.00×10-7) and the implicated 6p-risk region spans around 10Mb. Although our finding maps close to DYX2, where the dyslexia candidate genes DCDC2 and KIAA0319 have already been identified, our data point to the presence of an additional risk gene in this region and are highlighting the impact of 6p21 in dyslexia and related cognitive traits. © 2010 Wiley-Liss, Inc.

Original languageEnglish (US)
Pages (from-to)36-43
Number of pages8
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume156
Issue number1
DOIs
Publication statusPublished - Jan 2011
Externally publishedYes

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Keywords

  • DCDC2
  • Dyslexia
  • DYX2
  • Genome scan
  • KIAA0319
  • Linkage

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience
  • Medicine(all)

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