Mapping for dyslexia and related cognitive trait loci provides strong evidence for further risk genes on chromosome 6p21

Inke R. König; Johannes Schumacher; Per Hoffmann; André Kleensang; Kerstin U. Ludwig; Tiemo Grimm; Nina Neuhoff; Maike Preis; Darina Roeske; Andreas Warnke; Peter Propping; Helmut Remschmidt; Markus M. Nöthen; Andreas Ziegler; Bertram Müller-Myhsok; Gerd Schulte-Körne

doi:10.1002/ajmg.b.31135

Mapping for dyslexia and related cognitive trait loci provides strong evidence for further risk genes on chromosome 6p21

Inke R. König, Johannes Schumacher, Per Hoffmann, André Kleensang, Kerstin U. Ludwig, Tiemo Grimm, Nina Neuhoff, Maike Preis, Darina Roeske, Andreas Warnke, Peter Propping, Helmut Remschmidt, Markus M. Nöthen, Andreas Ziegler, Bertram Müller-Myhsok, Gerd Schulte-Körne

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

In a genome-wide linkage scan, we aimed at mapping risk loci for dyslexia in the German population. Our sample comprised 1,030 individuals from 246 dyslexia families which were recruited through a single-proband sib pair study design and a detailed assessment of dyslexia and related cognitive traits. We found evidence for a major dyslexia locus on chromosome 6p21. The cognitive trait rapid naming (objects/colors) produced a genome-wide significant LOD score of 5.87 (P=1.00×10^-7) and the implicated 6p-risk region spans around 10Mb. Although our finding maps close to DYX2, where the dyslexia candidate genes DCDC2 and KIAA0319 have already been identified, our data point to the presence of an additional risk gene in this region and are highlighting the impact of 6p21 in dyslexia and related cognitive traits. © 2010 Wiley-Liss, Inc.

Original language	English (US)
Pages (from-to)	36-43
Number of pages	8
Journal	American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume	156
Issue number	1
DOIs	https://doi.org/10.1002/ajmg.b.31135
State	Published - Jan 2011
Externally published	Yes

Keywords

DCDC2
DYX2
Dyslexia
Genome scan
KIAA0319
Linkage

ASJC Scopus subject areas

Genetics(clinical)
Psychiatry and Mental health
Cellular and Molecular Neuroscience

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König, I. R., Schumacher, J., Hoffmann, P., Kleensang, A., Ludwig, K. U., Grimm, T., Neuhoff, N., Preis, M., Roeske, D., Warnke, A., Propping, P., Remschmidt, H., Nöthen, M. M., Ziegler, A., Müller-Myhsok, B., & Schulte-Körne, G. (2011). Mapping for dyslexia and related cognitive trait loci provides strong evidence for further risk genes on chromosome 6p21. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 156(1), 36-43. https://doi.org/10.1002/ajmg.b.31135

König, IR, Schumacher, J, Hoffmann, P, Kleensang, A, Ludwig, KU, Grimm, T, Neuhoff, N, Preis, M, Roeske, D, Warnke, A, Propping, P, Remschmidt, H, Nöthen, MM, Ziegler, A, Müller-Myhsok, B & Schulte-Körne, G 2011, 'Mapping for dyslexia and related cognitive trait loci provides strong evidence for further risk genes on chromosome 6p21', American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, vol. 156, no. 1, pp. 36-43. https://doi.org/10.1002/ajmg.b.31135

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abstract = "In a genome-wide linkage scan, we aimed at mapping risk loci for dyslexia in the German population. Our sample comprised 1,030 individuals from 246 dyslexia families which were recruited through a single-proband sib pair study design and a detailed assessment of dyslexia and related cognitive traits. We found evidence for a major dyslexia locus on chromosome 6p21. The cognitive trait rapid naming (objects/colors) produced a genome-wide significant LOD score of 5.87 (P=1.00×10-7) and the implicated 6p-risk region spans around 10Mb. Although our finding maps close to DYX2, where the dyslexia candidate genes DCDC2 and KIAA0319 have already been identified, our data point to the presence of an additional risk gene in this region and are highlighting the impact of 6p21 in dyslexia and related cognitive traits. {\textcopyright} 2010 Wiley-Liss, Inc.",

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AU - Grimm, Tiemo

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AU - Propping, Peter

AU - Remschmidt, Helmut

AU - Nöthen, Markus M.

AU - Ziegler, Andreas

AU - Müller-Myhsok, Bertram

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Mapping for dyslexia and related cognitive trait loci provides strong evidence for further risk genes on chromosome 6p21

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Keywords

ASJC Scopus subject areas

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