Manually Adjusted Versus Vendor-Preset Definition of Metabolite Boundaries. Impact on Proton Metabolite Ratios

Myria Petrou, Pia C. Sundgren, Yuxi Pang, Suzan Rohrer, Bradley Foerster, Thomas L. Chenevert

Research output: Contribution to journalArticle

Abstract

Rationale and Objectives: Metabolite peak boundary definition is an important postprocessing step in proton magnetic resonance spectroscopy (1H-MRS). We compare metabolite ratios calculated using three different postprocessing strategies: software-rendered default peak boundaries, manually adjusted peak boundaries and a curve-fitting program. The first two of these methods are commercially available. Materials and Methods: A total of 42 spectra acquired on a 1.5-T MR unit using two-dimensional chemical shift proton MR spectroscopy (TR/TE = 1500/144 ms) were analyzed. Choline (Cho), creatine (Cr), and N-acetylaspartate (NAA) relative concentrations were derived and the following metabolite ratios were calculated: Cho/Cr, Cho/NAA, and NAA/Cr. Metabolite concentrations/ratios were calculated using (a) default peak boundaries rendered by commercially available, postprocessing software (Functool 2000, version 2.6.0); (b) manually adjusted peak boundaries by an experienced spectroscopist, using an option offered by the same commercially available software; and (c) an offline in-house curve-fitting program. Measurements obtained with method (c) were considered as the "gold standard." Paired t-tests comparing default and adjusted metabolite ratios, as well as default and adjusted ratios with their respective curve-fit values were used for statistical analysis. Results: Significant differences between default and manually adjusted values were found for Cho/Cr ratios

Original languageEnglish (US)
Pages (from-to)340-343
Number of pages4
JournalAcademic Radiology
Volume14
Issue number3
DOIs
StatePublished - Mar 2007
Externally publishedYes

Fingerprint

Creatine
Choline
Protons
Software
Magnetic Resonance Spectroscopy
N-acetylaspartate
Proton Magnetic Resonance Spectroscopy

Keywords

  • metabolite ratios
  • post-processing
  • proton MR spectroscopy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Manually Adjusted Versus Vendor-Preset Definition of Metabolite Boundaries. Impact on Proton Metabolite Ratios. / Petrou, Myria; Sundgren, Pia C.; Pang, Yuxi; Rohrer, Suzan; Foerster, Bradley; Chenevert, Thomas L.

In: Academic Radiology, Vol. 14, No. 3, 03.2007, p. 340-343.

Research output: Contribution to journalArticle

Petrou, M, Sundgren, PC, Pang, Y, Rohrer, S, Foerster, B & Chenevert, TL 2007, 'Manually Adjusted Versus Vendor-Preset Definition of Metabolite Boundaries. Impact on Proton Metabolite Ratios', Academic Radiology, vol. 14, no. 3, pp. 340-343. https://doi.org/10.1016/j.acra.2006.12.011
Petrou, Myria ; Sundgren, Pia C. ; Pang, Yuxi ; Rohrer, Suzan ; Foerster, Bradley ; Chenevert, Thomas L. / Manually Adjusted Versus Vendor-Preset Definition of Metabolite Boundaries. Impact on Proton Metabolite Ratios. In: Academic Radiology. 2007 ; Vol. 14, No. 3. pp. 340-343.
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