Mantle irradiation alone for selected patients with laparotomy-staged IA to IIA Hodgkin's disease: Preliminary results of a prospective trial

Peter M. Mauch, George P. Canellos, Lawrence N. Shulman, Barbara Silver, Nancy J. Tarbell, Steven Come, Michael S. Rabin, C. Norman Coleman

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To determine the feasibility of omitting prophylactic paraaortic irradiation in selected patients with laparotomy-staged (pathologically staged [PS]) IA to IIA Hodgkin's disease. Patients and Methods: We initiated a prospective single-arm trial in October 1988 to study the role of mantle irradiation alone in selected PS IA to IIA patients with Hodgkin's disease. A total of 37 patients have been entered onto this trial. Entrance criteria included nodular sclerosis (NS) or lymphocyte predominance (LP) histology, absence of B symptoms, disease limited above the carina, and a negative laparotomy. Results of treatment of 23 patients in the prospective trial, monitored off treatment for ≥ 1 year, are presented. Twenty-three additional PS IA to IIA patients, treated with mantle irradiation alone from 1970 to 1987, were analyzed as a comparison group. The median follow-up durations were 32 and 113 months, respectively, for the two groups. Results: The 4- year actuarial rates of freedom from relapse and overall survival are 83% and 100%, respectively, for the prospective trial. The 10-year actuarial rates of freedom from relapse and overall survival are 83% and 89%, respectively, for retrospectively studied patients. There have been five recurrences among 46 patients who received mantle irradiation alone, all with a component of relapse below the diaphragm. Conclusion: These early results support the use of mantle irradiation alone in selected PS IA to IIA patients with NS or LP histology. Relapses, although rare, have occurred predominantly below the diaphragm. This suggests the need for continued long-term surveillance of abdominal and pelvic nodes in this group of treated patients.

Original languageEnglish (US)
Pages (from-to)947-952
Number of pages6
JournalJournal of Clinical Oncology
Volume13
Issue number4
DOIs
StatePublished - Apr 1995
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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