Mantle Cell Lymphoma With Mantle Zone Growth Pattern

Ji Yuan, Shaoying Li, Xin Liu, Ruijun Jeanna Su, Mingyi Chen, Xiaojun Wu, Gang Zheng, Lynette M. Smith, Lifu Wang, Yanxia Li, Cynthia Liu, Jiehao Zhou, Qi Shen, Linsheng Zhang, Endi Wang, Mina L. Xu, Zenggang Pan

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: To characterize the clinical and pathologic features of mantle cell lymphoma with mantle zone growth pattern (MCL-MZGP). METHODS: The clinicopathologic data from 35 cases of MCL-MZGP obtained in 12 centers were analyzed. RESULTS: The patients with MCL-MZGP typically sought treatment at high clinical stages (81%). Intriguingly, 40% (14/35) of cases were incidentally noted. The lymph nodes with MCL-MZGP showed preserved architecture and expanded mantles containing lymphoma cells with classic or small cell cytology. MCL-MZGP was positive for BCL2 (96%, bright), CD5 (82%, moderate), cyclin D1 (100%), and SOX11 (89%). Clinically, our study revealed no significant difference in the overall survival between patients managed with observation alone and those who received chemotherapy. CONCLUSIONS: MCL-MZGP was often incidentally identified and resembled reactive mantles. Therefore, recognition of this unusual morphology emphasizes the utility of cyclin D1 immunostain in the cases with suspicious morphology. However, the clinical significance of these findings is still unclear.

Original languageEnglish (US)
Pages (from-to)132-145
Number of pages14
JournalAmerican journal of clinical pathology
Volume152
Issue number2
DOIs
StatePublished - Jul 5 2019

Fingerprint

Mantle-Cell Lymphoma
Growth
Cyclin D1
Cell Biology
Lymph Nodes
Observation
Drug Therapy
Survival

Keywords

  • Cyclin D1
  • Mantle cell lymphoma
  • Mantle zone growth pattern
  • SOX11

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Yuan, J., Li, S., Liu, X., Su, R. J., Chen, M., Wu, X., ... Pan, Z. (2019). Mantle Cell Lymphoma With Mantle Zone Growth Pattern. American journal of clinical pathology, 152(2), 132-145. https://doi.org/10.1093/ajcp/aqz043

Mantle Cell Lymphoma With Mantle Zone Growth Pattern. / Yuan, Ji; Li, Shaoying; Liu, Xin; Su, Ruijun Jeanna; Chen, Mingyi; Wu, Xiaojun; Zheng, Gang; Smith, Lynette M.; Wang, Lifu; Li, Yanxia; Liu, Cynthia; Zhou, Jiehao; Shen, Qi; Zhang, Linsheng; Wang, Endi; Xu, Mina L.; Pan, Zenggang.

In: American journal of clinical pathology, Vol. 152, No. 2, 05.07.2019, p. 132-145.

Research output: Contribution to journalArticle

Yuan, J, Li, S, Liu, X, Su, RJ, Chen, M, Wu, X, Zheng, G, Smith, LM, Wang, L, Li, Y, Liu, C, Zhou, J, Shen, Q, Zhang, L, Wang, E, Xu, ML & Pan, Z 2019, 'Mantle Cell Lymphoma With Mantle Zone Growth Pattern', American journal of clinical pathology, vol. 152, no. 2, pp. 132-145. https://doi.org/10.1093/ajcp/aqz043
Yuan, Ji ; Li, Shaoying ; Liu, Xin ; Su, Ruijun Jeanna ; Chen, Mingyi ; Wu, Xiaojun ; Zheng, Gang ; Smith, Lynette M. ; Wang, Lifu ; Li, Yanxia ; Liu, Cynthia ; Zhou, Jiehao ; Shen, Qi ; Zhang, Linsheng ; Wang, Endi ; Xu, Mina L. ; Pan, Zenggang. / Mantle Cell Lymphoma With Mantle Zone Growth Pattern. In: American journal of clinical pathology. 2019 ; Vol. 152, No. 2. pp. 132-145.
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AU - Smith, Lynette M.

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AU - Li, Yanxia

AU - Liu, Cynthia

AU - Zhou, Jiehao

AU - Shen, Qi

AU - Zhang, Linsheng

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AU - Pan, Zenggang

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AB - OBJECTIVES: To characterize the clinical and pathologic features of mantle cell lymphoma with mantle zone growth pattern (MCL-MZGP). METHODS: The clinicopathologic data from 35 cases of MCL-MZGP obtained in 12 centers were analyzed. RESULTS: The patients with MCL-MZGP typically sought treatment at high clinical stages (81%). Intriguingly, 40% (14/35) of cases were incidentally noted. The lymph nodes with MCL-MZGP showed preserved architecture and expanded mantles containing lymphoma cells with classic or small cell cytology. MCL-MZGP was positive for BCL2 (96%, bright), CD5 (82%, moderate), cyclin D1 (100%), and SOX11 (89%). Clinically, our study revealed no significant difference in the overall survival between patients managed with observation alone and those who received chemotherapy. CONCLUSIONS: MCL-MZGP was often incidentally identified and resembled reactive mantles. Therefore, recognition of this unusual morphology emphasizes the utility of cyclin D1 immunostain in the cases with suspicious morphology. However, the clinical significance of these findings is still unclear.

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