Manipulation of opiate activity in the amygdala alters memory processes

M. Gallagher; B. S. Kapp

doi:10.1016/0024-3205(78)90565-9

Manipulation of opiate activity in the amygdala alters memory processes

Research output: Contribution to journal › Article › peer-review

Abstract

The opiate agonist, levorphanol, injected into the amygdala complex of rats following passive avoidance conditioning produced time-dependent and dose-dependent decreases in retention. This effect obtained with levorphanol was observed to be stereospecific. In addition, post-training administration of the opiate antagonist, naloxone, into the amygdala significantly increased retention of passive avoidance conditioning in a time-dependent and dose-dependent manner. Finally, these opposing effects of opiate agonist and antagonist administration were blocked by combined administration of levorphanol and naloxone. These data support a possible role for amygdala opioid peptides in time-dependent memory processes.

Original language	English (US)
Pages (from-to)	1973-1977
Number of pages	5
Journal	Life Sciences
Volume	23
Issue number	19
DOIs	https://doi.org/10.1016/0024-3205(78)90565-9
State	Published - Nov 9 1978
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

Access to Document

10.1016/0024-3205(78)90565-9

Cite this

@article{ca76d7a09d7846f79971ea59920ebfe7,

title = "Manipulation of opiate activity in the amygdala alters memory processes",

abstract = "The opiate agonist, levorphanol, injected into the amygdala complex of rats following passive avoidance conditioning produced time-dependent and dose-dependent decreases in retention. This effect obtained with levorphanol was observed to be stereospecific. In addition, post-training administration of the opiate antagonist, naloxone, into the amygdala significantly increased retention of passive avoidance conditioning in a time-dependent and dose-dependent manner. Finally, these opposing effects of opiate agonist and antagonist administration were blocked by combined administration of levorphanol and naloxone. These data support a possible role for amygdala opioid peptides in time-dependent memory processes.",

author = "M. Gallagher and Kapp, {B. S.}",

note = "Funding Information: *Supported by NIH grant R03 01577-01, and a Research Scientist Development Award K02 MH00118 (NIMH) to B .S .R .",

year = "1978",

month = nov,

day = "9",

doi = "10.1016/0024-3205(78)90565-9",

language = "English (US)",

volume = "23",

pages = "1973--1977",

journal = "Life Sciences",

issn = "0024-3205",

publisher = "Elsevier Inc.",

number = "19",

}

TY - JOUR

T1 - Manipulation of opiate activity in the amygdala alters memory processes

AU - Gallagher, M.

AU - Kapp, B. S.

N1 - Funding Information: *Supported by NIH grant R03 01577-01, and a Research Scientist Development Award K02 MH00118 (NIMH) to B .S .R .

PY - 1978/11/9

Y1 - 1978/11/9

N2 - The opiate agonist, levorphanol, injected into the amygdala complex of rats following passive avoidance conditioning produced time-dependent and dose-dependent decreases in retention. This effect obtained with levorphanol was observed to be stereospecific. In addition, post-training administration of the opiate antagonist, naloxone, into the amygdala significantly increased retention of passive avoidance conditioning in a time-dependent and dose-dependent manner. Finally, these opposing effects of opiate agonist and antagonist administration were blocked by combined administration of levorphanol and naloxone. These data support a possible role for amygdala opioid peptides in time-dependent memory processes.

AB - The opiate agonist, levorphanol, injected into the amygdala complex of rats following passive avoidance conditioning produced time-dependent and dose-dependent decreases in retention. This effect obtained with levorphanol was observed to be stereospecific. In addition, post-training administration of the opiate antagonist, naloxone, into the amygdala significantly increased retention of passive avoidance conditioning in a time-dependent and dose-dependent manner. Finally, these opposing effects of opiate agonist and antagonist administration were blocked by combined administration of levorphanol and naloxone. These data support a possible role for amygdala opioid peptides in time-dependent memory processes.

UR - http://www.scopus.com/inward/record.url?scp=0018167052&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018167052&partnerID=8YFLogxK

U2 - 10.1016/0024-3205(78)90565-9

DO - 10.1016/0024-3205(78)90565-9

M3 - Article

C2 - 214656

AN - SCOPUS:0018167052

VL - 23

SP - 1973

EP - 1977

JO - Life Sciences

JF - Life Sciences

SN - 0024-3205

IS - 19

ER -

Manipulation of opiate activity in the amygdala alters memory processes

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this