Manipulation of opiate activity in the amygdala alters memory processes

Michela Gallagher, B. S. Kapp

Research output: Contribution to journalArticle

Abstract

The opiate agonist, levorphanol, injected into the amygdala complex of rats following passive avoidance conditioning produced time-dependent and dose-dependent decreases in retention. This effect obtained with levorphanol was observed to be stereospecific. In addition, post-training administration of the opiate antagonist, naloxone, into the amygdala significantly increased retention of passive avoidance conditioning in a time-dependent and dose-dependent manner. Finally, these opposing effects of opiate agonist and antagonist administration were blocked by combined administration of levorphanol and naloxone. These data support a possible role for amygdala opioid peptides in time-dependent memory processes.

Original languageEnglish (US)
Pages (from-to)1973-1977
Number of pages5
JournalLife Sciences
Volume23
Issue number19
DOIs
StatePublished - Nov 9 1978
Externally publishedYes

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Opiate Alkaloids
Levorphanol
Amygdala
Naloxone
Data storage equipment
Opioid Peptides
Rats
Conditioning (Psychology)
Retention (Psychology)

ASJC Scopus subject areas

  • Pharmacology

Cite this

Manipulation of opiate activity in the amygdala alters memory processes. / Gallagher, Michela; Kapp, B. S.

In: Life Sciences, Vol. 23, No. 19, 09.11.1978, p. 1973-1977.

Research output: Contribution to journalArticle

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