Abstract
The opiate agonist, levorphanol, injected into the amygdala complex of rats following passive avoidance conditioning produced time-dependent and dose-dependent decreases in retention. This effect obtained with levorphanol was observed to be stereospecific. In addition, post-training administration of the opiate antagonist, naloxone, into the amygdala significantly increased retention of passive avoidance conditioning in a time-dependent and dose-dependent manner. Finally, these opposing effects of opiate agonist and antagonist administration were blocked by combined administration of levorphanol and naloxone. These data support a possible role for amygdala opioid peptides in time-dependent memory processes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1973-1977 |
| Number of pages | 5 |
| Journal | Life Sciences |
| Volume | 23 |
| Issue number | 19 |
| DOIs | |
| State | Published - Nov 9 1978 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pharmacology
Cite this
Manipulation of opiate activity in the amygdala alters memory processes. / Gallagher, Michela; Kapp, B. S.
In: Life Sciences, Vol. 23, No. 19, 09.11.1978, p. 1973-1977.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Manipulation of opiate activity in the amygdala alters memory processes
AU - Gallagher, Michela
AU - Kapp, B. S.
PY - 1978/11/9
Y1 - 1978/11/9
N2 - The opiate agonist, levorphanol, injected into the amygdala complex of rats following passive avoidance conditioning produced time-dependent and dose-dependent decreases in retention. This effect obtained with levorphanol was observed to be stereospecific. In addition, post-training administration of the opiate antagonist, naloxone, into the amygdala significantly increased retention of passive avoidance conditioning in a time-dependent and dose-dependent manner. Finally, these opposing effects of opiate agonist and antagonist administration were blocked by combined administration of levorphanol and naloxone. These data support a possible role for amygdala opioid peptides in time-dependent memory processes.
AB - The opiate agonist, levorphanol, injected into the amygdala complex of rats following passive avoidance conditioning produced time-dependent and dose-dependent decreases in retention. This effect obtained with levorphanol was observed to be stereospecific. In addition, post-training administration of the opiate antagonist, naloxone, into the amygdala significantly increased retention of passive avoidance conditioning in a time-dependent and dose-dependent manner. Finally, these opposing effects of opiate agonist and antagonist administration were blocked by combined administration of levorphanol and naloxone. These data support a possible role for amygdala opioid peptides in time-dependent memory processes.
UR - http://www.scopus.com/inward/record.url?scp=0018167052&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018167052&partnerID=8YFLogxK
U2 - 10.1016/0024-3205(78)90565-9
DO - 10.1016/0024-3205(78)90565-9
M3 - Article
C2 - 214656
AN - SCOPUS:0018167052
VL - 23
SP - 1973
EP - 1977
JO - Life Sciences
JF - Life Sciences
SN - 0024-3205
IS - 19
ER -