Manipulation of opiate activity in the amygdala alters memory processes

M. Gallagher, B. S. Kapp

Research output: Contribution to journalArticlepeer-review

Abstract

The opiate agonist, levorphanol, injected into the amygdala complex of rats following passive avoidance conditioning produced time-dependent and dose-dependent decreases in retention. This effect obtained with levorphanol was observed to be stereospecific. In addition, post-training administration of the opiate antagonist, naloxone, into the amygdala significantly increased retention of passive avoidance conditioning in a time-dependent and dose-dependent manner. Finally, these opposing effects of opiate agonist and antagonist administration were blocked by combined administration of levorphanol and naloxone. These data support a possible role for amygdala opioid peptides in time-dependent memory processes.

Original languageEnglish (US)
Pages (from-to)1973-1977
Number of pages5
JournalLife Sciences
Volume23
Issue number19
DOIs
StatePublished - Nov 9 1978
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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