Abstract
The Kapsosi's sarcoma-associated herpesvirus, KSHV, is associated with cancers that have increased incidence in patients who are also HIV positive or who have undergone organ transplantation. It has recently been observed that β-catenin is overexpressed in two KSHV-associated cancers, Kaposi's sarcoma and primary effusion lymphoma. Investigation of the underlying defect in β-catenin regulation revealed that the KSHV-encoded LANA protein stabilizes β-catenin by binding to the negative regulator GSK-3, causing a cell-cycle-dependent nuclear accumulation of GSK-3. Thus, redistribution of GSK-3 has been identified as yet another mechanism through which β-catenin can be dysregulated and contribute to human cancer.
Original language | English (US) |
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Pages (from-to) | 223-231 |
Number of pages | 9 |
Journal | Journal of Molecular Medicine |
Volume | 82 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2004 |
Keywords
- GSK-3
- Kaposi's sarcoma-associated herpesvirus
- Latency-associated nuclear antigen
- Wnt pathway
- β-catenin
ASJC Scopus subject areas
- Molecular Medicine
- Drug Discovery
- Genetics(clinical)