Manipulation of glycogen-synthase kinase-3 activity in KSHV-associated cancers

Masahiro Fujimuro, S. Diane Hayward

Research output: Contribution to journalReview article

Abstract

The Kapsosi's sarcoma-associated herpesvirus, KSHV, is associated with cancers that have increased incidence in patients who are also HIV positive or who have undergone organ transplantation. It has recently been observed that β-catenin is overexpressed in two KSHV-associated cancers, Kaposi's sarcoma and primary effusion lymphoma. Investigation of the underlying defect in β-catenin regulation revealed that the KSHV-encoded LANA protein stabilizes β-catenin by binding to the negative regulator GSK-3, causing a cell-cycle-dependent nuclear accumulation of GSK-3. Thus, redistribution of GSK-3 has been identified as yet another mechanism through which β-catenin can be dysregulated and contribute to human cancer.

Original languageEnglish (US)
Pages (from-to)223-231
Number of pages9
JournalJournal of Molecular Medicine
Volume82
Issue number4
DOIs
StatePublished - Apr 1 2004

Keywords

  • GSK-3
  • Kaposi's sarcoma-associated herpesvirus
  • Latency-associated nuclear antigen
  • Wnt pathway
  • β-catenin

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery
  • Genetics(clinical)

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