Manifold based morphometry applied to schizophrenia

Ragini Verma, Parmeshwar Khurd, James Loughead, Raquel Gur, Ruben Gur, Christos Davatzikos

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The growing clinical importance of Diffusion tensor imaging (DTI) in disease investigation has prompted large population studies that require computational neuroanatomic techniques for tensor processing, as conventional analysis of scalar maps of DTI does not identify the full impact of pathology. In this paper we propose a comprehensive framework called Manifold Based Morphometry (MBM) for the computational and statistical analysis of DTI datasets, consisting of spatial normalization to a template, followed by voxel-based analysis based on embedding the tensors to a linear submanifold using kernel-based manifold learning and applying statistics in this embedded space. Regions of significant difference are identified and compared with those found with conventional voxel-based analysis of scalar maps of anisotropy and diffusivity. MBM has then been applied to the group-based statistical analysis of dataset of schizophrenia patients and controls. The comparison yields that MBM consisting of the full tensor DTI analysis reveals regions of difference that encompass regions identified by the analysis of scalar maps thereby reinforcing the comprehensive nature of the designed framework.

Original languageEnglish (US)
Title of host publication2008 5th IEEE International Symposium on Biomedical Imaging
Subtitle of host publicationFrom Nano to Macro, Proceedings, ISBI
Pages704-707
Number of pages4
DOIs
StatePublished - Sep 10 2008
Event2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI - Paris, France
Duration: May 14 2008May 17 2008

Publication series

Name2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, Proceedings, ISBI

Other

Other2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI
CountryFrance
CityParis
Period5/14/085/17/08

Keywords

  • Diffusion tensor imaging
  • Manifolds
  • Population study
  • Schizophrenia
  • Statistics
  • Voxel-based analysis

ASJC Scopus subject areas

  • Biomedical Engineering

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