Mania: Psychiatric manifestations of the antiphospholipid syndrome

Haniya Raza, Steven A. Epstein, Maryland Pao, Donald L. Rosenstein

Research output: Contribution to journalLetterpeer-review

17 Scopus citations


Background: Antiphospholipid syndrome (APS) is a prothrombotic condition characterized by recurrent vascular thrombosis and/or pregnancy morbidity in the presence of circulating antiphospholipid antibodies. Central nervous system (CNS) involvement is a prominent feature of APS, and many neurological manifestations have been described in published reports. There are limited data on psychiatric syndromes occurring in association with APS, and there have been no previous reports of mania associated with APS. Method: The authors present the case of a 31-year-old man who experienced an acute manic episode in association with APS. They review the literature on psychiatric manifestations of APS, discuss potential mechanisms of CNS pathogenesis, and consider diagnostic and treatment implications of the co-occurrence of APS and psychiatric symptoms.

Original languageEnglish (US)
Pages (from-to)438-441
Number of pages4
Issue number5
StatePublished - 2008
Externally publishedYes

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Applied Psychology
  • Psychiatry and Mental health


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