Mania after brain injury: Neuroradiological and metabolic findings

Sergio E. Starkstein, Helen S. Mayberg, Marcelo L. Berthier, Paul Fedoroff, Thomas R. Price, Robert F Dannals, Henry N. Wagner, Ramon Leiguarda, Robert G. Robinson

Research output: Contribution to journalArticle

Abstract

We present a consecutive series of 8 patients who developed a manic episode after a brain injury. Five patients had cortical lesions (4 with damage to the right basotemporal region, and 1 with bilateral damage to the orbitofrontal area). While the other 3 patients had subcortical lesions (white matter of the right frontal lobe, right anterior limb of the internal capsule, and right head of the caudate), a 18fluorodeoxyglucose positron emission tomography scan showed hypometabolism in the right lateral basotemporal region in all 3 patients. These findings suggest a major role for the basal region of the right temporal lobe in the modulation of mood.

Original languageEnglish (US)
Pages (from-to)652-659
Number of pages8
JournalAnnals of Neurology
Volume27
Issue number6
StatePublished - Jun 1990

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Bipolar Disorder
Brain Injuries
Internal Capsule
Frontal Lobe
Temporal Lobe
Positron-Emission Tomography
Extremities

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Starkstein, S. E., Mayberg, H. S., Berthier, M. L., Fedoroff, P., Price, T. R., Dannals, R. F., ... Robinson, R. G. (1990). Mania after brain injury: Neuroradiological and metabolic findings. Annals of Neurology, 27(6), 652-659.

Mania after brain injury : Neuroradiological and metabolic findings. / Starkstein, Sergio E.; Mayberg, Helen S.; Berthier, Marcelo L.; Fedoroff, Paul; Price, Thomas R.; Dannals, Robert F; Wagner, Henry N.; Leiguarda, Ramon; Robinson, Robert G.

In: Annals of Neurology, Vol. 27, No. 6, 06.1990, p. 652-659.

Research output: Contribution to journalArticle

Starkstein, SE, Mayberg, HS, Berthier, ML, Fedoroff, P, Price, TR, Dannals, RF, Wagner, HN, Leiguarda, R & Robinson, RG 1990, 'Mania after brain injury: Neuroradiological and metabolic findings', Annals of Neurology, vol. 27, no. 6, pp. 652-659.
Starkstein SE, Mayberg HS, Berthier ML, Fedoroff P, Price TR, Dannals RF et al. Mania after brain injury: Neuroradiological and metabolic findings. Annals of Neurology. 1990 Jun;27(6):652-659.
Starkstein, Sergio E. ; Mayberg, Helen S. ; Berthier, Marcelo L. ; Fedoroff, Paul ; Price, Thomas R. ; Dannals, Robert F ; Wagner, Henry N. ; Leiguarda, Ramon ; Robinson, Robert G. / Mania after brain injury : Neuroradiological and metabolic findings. In: Annals of Neurology. 1990 ; Vol. 27, No. 6. pp. 652-659.
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