Manganese-induced Parkinsonism in mice is reduced using a novel contaminated water sediment exposure model

Dana M. Freeman, Rachel O'Neal, Qiang Zhang, Edward J. Bouwer, Zhibin Wang

Research output: Contribution to journalArticle

Abstract

Heavy metals enter the aquatic environment and accumulate within water sediments, but these metal-sediment interactions remain to be explored within toxicity studies. We developed an exposure model in mice that encapsulates the aquatic microenvironment of metals before exposure. Male and female C57/BL6 mice were exposed via their drinking water to manganese contaminated sediment (Sed_Mn) or to manganese without sediment interaction (Mn) for six weeks. Sediment interaction did not alter weekly manganese ingestion from water in males or females. We analyzed motor impairment, a common feature in manganese-induced Parkinsonism, using the beam traversal, cylinder, and accelerating rotarod tests. Sed_Mn mice performed better overall compared to Mn mice and males were more sensitive to manganese than females in both Sed_Mn and Mn treatment groups. Our study indicates that metal-sediment interactions may alter metal toxicity in mammals and introduces a new exposure model to test the toxicity of metal contaminants of drinking water.

Original languageEnglish (US)
Article number103399
JournalEnvironmental Toxicology and Pharmacology
Volume78
DOIs
StatePublished - Aug 2020

Keywords

  • Behavior toxicity
  • Geologic sediments
  • Heavy metals toxicity
  • Manganese
  • Mouse

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology
  • Health, Toxicology and Mutagenesis

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