Manganese homeostasis in saccharomyces cerevisiae

Amit R. Reddi, Laran T. Jensen, Valeria C. Culotta

Research output: Contribution to journalArticlepeer-review

79 Scopus citations


A review focused on global manganese homeostatic pathways operative in the eukaryotic cell of Saccharomyces cerevisiae (yeast). It highlighted the mechanisms by which cell surface and intercellular manganese transporters imported and distributed manganese, along with the way these homeostatic mechanisms responded to manganese deficiency or surplus. The manner in which cells mediated the uptake and distribution of manganese was dependent on the exposure of environmental manganese to the cell. It was also revealed that the range of intracellular manganese levels that constituted manganese sufficiency was significantly large. It was demonstrated that manganese starvation conditions in yeast were achieved by growing cells in a special defined medium that was depleted of manganese through ion exchange.

Original languageEnglish (US)
Pages (from-to)4722-4732
Number of pages11
JournalChemical Reviews
Issue number10
StatePublished - Oct 14 2009

ASJC Scopus subject areas

  • Chemistry(all)


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