A review focused on global manganese homeostatic pathways operative in the eukaryotic cell of Saccharomyces cerevisiae (yeast). It highlighted the mechanisms by which cell surface and intercellular manganese transporters imported and distributed manganese, along with the way these homeostatic mechanisms responded to manganese deficiency or surplus. The manner in which cells mediated the uptake and distribution of manganese was dependent on the exposure of environmental manganese to the cell. It was also revealed that the range of intracellular manganese levels that constituted manganese sufficiency was significantly large. It was demonstrated that manganese starvation conditions in yeast were achieved by growing cells in a special defined medium that was depleted of manganese through ion exchange.
ASJC Scopus subject areas