Managing the genomic revolution in cancer diagnostics

Doreen Nguyen, Christopher Gocke

Research output: Contribution to journalArticle

Abstract

Molecular tumor profiling is now a routine part of patient care, revealing targetable genomic alterations and molecularly distinct tumor subtypes with therapeutic and prognostic implications. The widespread adoption of next-generation sequencing technologies has greatly facilitated clinical implementation of genomic data and opened the door for high-throughput multigene-targeted sequencing. Herein, we discuss the variability of cancer genetic profiling currently offered by clinical laboratories, the challenges of applying rapidly evolving medical knowledge to individual patients, and the need for more standardized population-based molecular profiling.

Original languageEnglish (US)
Pages (from-to)1-21
Number of pages21
JournalVirchows Archiv
DOIs
StateAccepted/In press - Jun 21 2017

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Neoplasms
Patient Care
Technology
Population
Therapeutics

Keywords

  • Cancer panels
  • Mutations
  • Next generation sequencing
  • NGS

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

Cite this

Managing the genomic revolution in cancer diagnostics. / Nguyen, Doreen; Gocke, Christopher.

In: Virchows Archiv, 21.06.2017, p. 1-21.

Research output: Contribution to journalArticle

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