Managing the genomic revolution in cancer diagnostics

Doreen Nguyen, Christopher D. Gocke

Research output: Contribution to journalArticlepeer-review


Molecular tumor profiling is now a routine part of patient care, revealing targetable genomic alterations and molecularly distinct tumor subtypes with therapeutic and prognostic implications. The widespread adoption of next-generation sequencing technologies has greatly facilitated clinical implementation of genomic data and opened the door for high-throughput multigene-targeted sequencing. Herein, we discuss the variability of cancer genetic profiling currently offered by clinical laboratories, the challenges of applying rapidly evolving medical knowledge to individual patients, and the need for more standardized population-based molecular profiling.

Original languageEnglish (US)
Pages (from-to)175-194
Number of pages20
JournalVirchows Archiv
Issue number2
StatePublished - Aug 1 2017


  • Cancer panels
  • Mutations
  • NGS
  • Next generation sequencing

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology


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