Management Options for Persistent Postoperative Acromegaly

Research output: Contribution to journalArticle

Abstract

This article presents management options for the patient with acromegaly after noncurative surgery. The current evidence for repeat surgery, adjuvant medical therapy with somatostatin analogues, dopamine agonists, the growth hormone receptor antagonist pegvisomant, combination medical therapy, and radiotherapy in the context of persistent postoperative disease are summarized. The relative advantages and disadvantages of each of these treatment modalities are explored, and a general treatment algorithm that integrates these modalities is proposed.

Original languageEnglish (US)
Pages (from-to)621-638
Number of pages18
JournalNeurosurgery Clinics of North America
Volume23
Issue number4
DOIs
StatePublished - Oct 2012

Fingerprint

Acromegaly
Somatotropin Receptors
Hormone Antagonists
Dopamine Agonists
Therapeutics
Somatostatin
Reoperation
Radiotherapy

Keywords

  • Acromegaly
  • Dopamine agonists
  • Growth-hormone adenoma
  • Persistent
  • Radiotherapy
  • Recurrent
  • Somatostatin analogues

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Management Options for Persistent Postoperative Acromegaly. / Mathioudakis, Nestoras Nicolas; Salvatori, Roberto.

In: Neurosurgery Clinics of North America, Vol. 23, No. 4, 10.2012, p. 621-638.

Research output: Contribution to journalArticle

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