Management of sickle cell disease in children

Suzie A. Noronha, Christy Sadreameli, John Strouse

Research output: Contribution to journalReview articlepeer-review

Abstract

Sickle cell disease (SCD) is a heterogeneous inherited disorder of hemoglobin that causes chronic hemolytic anemia, vaso-occlusion, and endothelial dysfunction. These physiologic derangements often lead to multiorgan damage in infancy and throughout childhood. The most common types of SCD are homozygous hemoglobin S (HbSS disease), hemoglobin SC disease, and sickle β thalassemia. HbSS disease and sickle β 0 thalassemia often are referred to as sickle cell anemia because they have similar severity. Screening and preventive measures, including infection prophylaxis and vaccination, have significantly improved outcomes for children with SCD. Evidence-based therapies, such as hydroxyurea and transfusion, play an important role in preventing progression of select complications. Many chronic complications develop insidiously and require multidisciplinary care for effective treatment. Primary care physicians, as well as physicians in many other disciplines, may care for these patients and should be familiar with the potential acute and chronic complications of this disease. This review addresses healthcare maintenance guidelines, common complications, and recommendations for management of pediatric patients with SCD.

Original languageEnglish (US)
Pages (from-to)495-502
Number of pages8
JournalSouthern Medical Journal
Volume109
Issue number9
DOIs
StatePublished - Sep 1 2016

Keywords

  • healthcare maintenance
  • Key Words children
  • primary care
  • sickle cell anemia
  • sickle cell disease

ASJC Scopus subject areas

  • Medicine(all)

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